Design, Synthesis, Molecular Docking of Novel Substituted Pyrimidinone Derivatives as Anticancer Agents

Polycyclic Aromatic Compounds ◽

10.1080/10406638.2020.1837888 ◽

2020 ◽

pp. 1-17

Author(s):

Amira Atef Ghoneim ◽

Ahmed Foud El-Farargy ◽

Rania B. Bakr

Keyword(s):

Molecular Docking ◽

Anticancer Agents ◽

Design Synthesis

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Design, synthesis, cytotoxicity, HuTopoIIα inhibitory activity and molecular docking studies of pyrazole derivatives as potential anticancer agents

Bioorganic Chemistry ◽

10.1016/j.bioorg.2016.10.001 ◽

2016 ◽

Vol 69 ◽

pp. 77-90 ◽

Author(s):

Raquib Alam ◽

Divya Wahi ◽

Raja Singh ◽

Devapriya Sinha ◽

Vibha Tandon ◽

...

Keyword(s):

Molecular Docking ◽

Anticancer Agents ◽

Inhibitory Activity ◽

Docking Studies ◽

Pyrazole Derivatives ◽

Design Synthesis ◽

Molecular Docking Studies

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Design, synthesis, and molecular docking of novel indole scaffold-based VEGFR-2 inhibitors as targeted anticancer agents

Archiv der Pharmazie ◽

10.1002/ardp.201700299 ◽

2018 ◽

Vol 351 (2) ◽

pp. 1700299 ◽

Author(s):

Hanaa M. Roaiah ◽

Iman A. Y. Ghannam ◽

Islam H. Ali ◽

Ahmed M. El Kerdawy ◽

Mamdouh M. Ali ◽

...

Keyword(s):

Molecular Docking ◽

Anticancer Agents ◽

Design Synthesis

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Design, Synthesis, Cytotoxic Evaluation and Molecular Docking of New Fluoroquinazolinones as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects

International Journal of Molecular Sciences ◽

10.3390/ijms19061731 ◽

2018 ◽

Vol 19 (6) ◽

pp. 1731 ◽

Author(s):

Mohamed Zayed ◽

Sahar Ahmed ◽

Saleh Ihmaid ◽

Hany Ahmed ◽

Heba Rateb ◽

...

Keyword(s):

Molecular Docking ◽

Anticancer Agents ◽

Tubulin Polymerization ◽

Inhibitory Effects ◽

Design Synthesis ◽

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Design, synthesis, biological evaluation and molecular docking studies of novel benzofuran–pyrazole derivatives as anticancer agents

Bioorganic Chemistry ◽

10.1016/j.bioorg.2015.08.006 ◽

2015 ◽

Vol 63 ◽

pp. 1-12 ◽

Author(s):

Somaia S. Abd El-Karim ◽

Manal M. Anwar ◽

Neama A. Mohamed ◽

Tamer Nasr ◽

Samia A. Elseginy

Keyword(s):

Molecular Docking ◽

Anticancer Agents ◽

Docking Studies ◽

Biological Evaluation ◽

Pyrazole Derivatives ◽

Design Synthesis ◽

Molecular Docking Studies

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Design, synthesis, molecular docking study, and biological evaluation of salicylaldimine derivatives as potential histone deacetylases inhibitors (HDACi) and anticancer agents

Archives of Pharmaceutical Sciences Ain Shams University ◽

10.21608/aps.2018.18729 ◽

2018 ◽

Vol 2 (1) ◽

pp. 1-15

Author(s):

Heba Hesham ◽

Deena Lasheen ◽

Khaled Abouzid

Keyword(s):

Molecular Docking ◽

Anticancer Agents ◽

Histone Deacetylases ◽

Docking Study ◽

Biological Evaluation ◽

Molecular Docking Study ◽

Design Synthesis ◽

Histone Deacetylases Inhibitors

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Antiproliferative 3-deoxysphingomyelin analogs: Design, synthesis, biological evaluation and molecular docking of pyrrolidine-based 3-deoxysphingomyelin analogs as anticancer agents

Bioorganic Chemistry ◽

10.1016/j.bioorg.2018.11.040 ◽

2019 ◽

Vol 84 ◽

pp. 444-455 ◽

Author(s):

Ahmed H.E. Hassan ◽

Hye Rim Park ◽

Yoon Mi Yoon ◽

Hye In Kim ◽

Sung Yeun Yoo ◽

...

Keyword(s):

Molecular Docking ◽

Anticancer Agents ◽

Biological Evaluation ◽

Design Synthesis

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Design, synthesis and molecular docking of new [1,2,4] triazolo[4,3-a]quinoxaline derivatives as anticancer agents targeting VEGFR-2 kinase

Molecular Diversity ◽

10.1007/s11030-021-10303-6 ◽

2021 ◽

Author(s):

Nawaf A. Alsaif ◽

Alaa Elwan ◽

Mohammed M. Alanazi ◽

Ahmad J. Obaidullah ◽

Wael A. Alanazi ◽

...

Keyword(s):

Molecular Docking ◽

Anticancer Agents ◽

Design Synthesis ◽

Quinoxaline Derivatives

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Design, synthesis, biological assessment and molecular docking studies of new 2-aminoimidazole-quinoxaline hybrids as potential anticancer agents

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy ◽

10.1016/j.saa.2017.12.063 ◽

2018 ◽

Vol 194 ◽

pp. 21-35 ◽

Author(s):

Zahra Ghanbarimasir ◽

Ahmadreza Bekhradnia ◽

Katayoun Morteza-Semnani ◽

Alireza Rafiei ◽

Nima Razzaghi-Asl ◽

...

Keyword(s):

Molecular Docking ◽

Anticancer Agents ◽

Docking Studies ◽

Biological Assessment ◽

Design Synthesis ◽

Molecular Docking Studies

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Design, Synthesis and Molecular Docking of Chalcone Derivatives as Potential Anticancer Agents

ChemistrySelect ◽

10.1002/slct.202004088 ◽

2021 ◽

Vol 6 (4) ◽

pp. 888-895

Author(s):

Heba M. Abosalim ◽

Manal A. Nael ◽

Tarek F. El‐Moselhy

Keyword(s):

Molecular Docking ◽

Anticancer Agents ◽

Design Synthesis ◽

Chalcone Derivatives

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[1,2,4]Triazolo[4,3-a]quinoxaline and [1,2,4]triazolo[4,3-a]quinoxaline-1-thiol-derived DNA intercalators: design, synthesis, molecular docking, in silico ADMET profiles and anti-proliferative evaluations

New Journal of Chemistry ◽

10.1039/d0nj02990d ◽

2021 ◽

Author(s):

Khaled El-Adl ◽

Abdel-Ghany A. El-Helby ◽

Helmy Sakr ◽

Alaa Elwan

Keyword(s):

Molecular Docking ◽

Anticancer Agents ◽

In Silico ◽

Dna Intercalation ◽

Design Synthesis ◽

Dna Intercalators ◽

In Silico Admet ◽

Quinoxaline Derivatives ◽

Hct 116 ◽

In view of their DNA intercalation activities as anticancer agents, 17 novel [1,2,4]triazolo[4,3-a]quinoxaline derivatives have been designed, synthesized and evaluated against HepG2, HCT-116 and MCF-7 cells.

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