NF-κB-dependency and consequent regulation of IL-8 in echinomycin-induced apoptosis of HT-29 colon cancer cells

2008 ◽  
Vol 32 (10) ◽  
pp. 1207-1214 ◽  
Author(s):  
J PARK ◽  
J CHANG ◽  
K BAE ◽  
K LEE ◽  
S CHOI ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Induced Apoptosis ◽  
Ht 29

scholarly journals Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis

2016 ◽  
Vol 14 (5) ◽  
pp. 4559-4566 ◽  
Author(s):  
Lin Yang ◽  
Yanqing Liu ◽  
Mei Wang ◽  
Yayun Qian ◽  
Xiaoyun Dong ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Signaling Axis ◽  
Induced Apoptosis ◽  
Ht 29

Involvement of AMPK Signaling Cascade in Capsaicin-Induced Apoptosis of HT-29 Colon Cancer Cells

2007 ◽  
Vol 1095 (1) ◽  
pp. 496-503 ◽  
Author(s):  
Y. M. KIM ◽  
J.-T. HWANG ◽  
D. W. KWAK ◽  
Y. K. LEE ◽  
O. J. PARK
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Signaling Cascade ◽  
Colon Cancer Cells ◽  
Ampk Signaling ◽  
Induced Apoptosis ◽  
Ht 29

scholarly journals Activation of caspase‐8 contributes to fucoidan‐induced apoptosis in HT‐29 human colon cancer cells

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Eun Ji Kim ◽  
So Young Park ◽  
Hee Sook Park ◽  
Ji Eun Hong ◽  
Min Jeong Sin ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Caspase 8 ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Induced Apoptosis ◽  
Human Colon Cancer Cells ◽  
Ht 29

Mechanisms of thiosulfinates from Allium tuberosum L.-induced apoptosis in HT-29 human colon cancer cells

2009 ◽  
Vol 188 (2) ◽  
pp. 142-147 ◽  
Author(s):  
Ju-Hye Lee ◽  
Hee-Sun Yang ◽  
Kyoung-Wuk Park ◽  
Jae-Yong Kim ◽  
Mi-Kyung Lee ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Allium Tuberosum ◽  
Induced Apoptosis ◽  
Human Colon Cancer Cells ◽  
Ht 29

scholarly journals Nutrient Availability Alters the Effect of Autophagy on Sulindac Sulfide-Induced Colon Cancer Cell Apoptosis

2012 ◽  
Vol 2012 ◽  
pp. 1-9
Author(s):  
Shiun-Kwei Chiou ◽  
Neil Hoa ◽  
Lisheng Ge ◽  
Martin R. Jadus
Keyword(s):  
Colon Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Autophagy Induction ◽  
A Cell ◽  
Sulindac Sulfide ◽  
Induced Apoptosis ◽  
Apoptosis Inhibitor ◽  
Ht 29

Autophagy is a catabolic process by which a cell degrades its intracellular materials to replenish itself. Induction of autophagy under various cellular stress stimuli can lead to either cell survival or cell death via apoptotic and/or autophagic (nonapoptotic) pathways. The NSAID sulindac sulfide induces apoptosis in colon cancer cells. Here, we show that inhibition of autophagy under serum-deprived conditions resulted in significant reductions of sulindac sulfide-induced apoptosis in HT-29 colon cancer cells. In contrast, inhibition of autophagy under conditions where serum is available significantly increased sulindac sulfide-induced apoptosis in HT-29 cells. We previously showed that the apoptosis inhibitor, survivin, plays a role in regulating NSAID-induced apoptosis and autophagic cell death. Here, we show that survivin protein half-life is increased in the presence of autophagy inhibitors under serum-deprived conditions, but not under conditions when serum is available. Thus, the increased levels of survivin may be a factor contributing to inhibition of sulindac sulfide-induced apoptosis under serum-deprived conditions. These results suggest that whether a cell lives or dies due to autophagy induction depends on the balance of factors that regulate both autophagic and apoptotic processes.

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