scholarly journals The LPA2 receptor agonist Radioprotectin-1 spares Lgr5-positive intestinal stem cells from radiation injury in murine enteroids

2018 ◽  
Vol 51 ◽  
pp. 23-33 ◽  
Author(s):  
Bryan Kuo ◽  
Erzsébet Szabó ◽  
Sue Chin Lee ◽  
Andrea Balogh ◽  
Derek Norman ◽  
...  
Keyword(s):  
Stem Cells ◽  
Receptor Agonist ◽  
Radiation Injury ◽  
Intestinal Stem Cells

scholarly journals Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Yuhua Tian ◽  
Xianghui Ma ◽  
Cong Lv ◽  
Xiaole Sheng ◽  
Xiang Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Radiation Injury ◽  
Intestinal Stem Cells ◽  
Potential Therapeutic Target ◽  
Intestinal Homeostasis ◽  
Intestinal Tumorigenesis ◽  
Stat3 Signaling ◽  
Coordinate Control ◽  
Stat3 Signaling Pathway

Intestinal regeneration and tumorigenesis are believed to be driven by intestinal stem cells (ISCs). Elucidating mechanisms underlying ISC activation during regeneration and tumorigenesis can help uncover the underlying principles of intestinal homeostasis and disease including colorectal cancer. Here we show that miR-31 drives ISC proliferation, and protects ISCs against apoptosis, both during homeostasis and regeneration in response to ionizing radiation injury. Furthermore, miR-31 has oncogenic properties, promoting intestinal tumorigenesis. Mechanistically, miR-31 acts to balance input from Wnt, BMP, TGFβ signals to coordinate control of intestinal homeostasis, regeneration and tumorigenesis. We further find that miR-31 is regulated by the STAT3 signaling pathway in response to radiation injury. These findings identify miR-31 as a critical modulator of ISC biology, and a potential therapeutic target for a broad range of intestinal regenerative disorders and cancers.

scholarly journals Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Subhrajit Saha ◽  
Evelyn Aranda ◽  
Yoku Hayakawa ◽  
Payel Bhanja ◽  
Safinur Atay ◽  
...  
Keyword(s):  
Stem Cells ◽  
Radiation Injury ◽  
Extracellular Vesicle ◽  
Intestinal Stem Cells

Epithelial Regeneration after Doxorubicin Arises Primarily from Early Progeny of Active Intestinal Stem Cells

2020 ◽  
Author(s):  
Breanna Sheahan ◽  
Ally N. Freeman ◽  
Theresa M. Keeley ◽  
Linda C. Samuelson ◽  
Jatin Roper ◽  
...  
Keyword(s):  
Stem Cells ◽  
Intestinal Stem Cells ◽  
Epithelial Regeneration

Combined therapy of mesenchymal stem cells with a GLP-1 receptor agonist, liraglutide, on an inflammatory-mediated diabetic non-human primate model

Life Sciences ◽  
2021 ◽  
Vol 276 ◽  
pp. 119374
Author(s):  
Roghayeh Navabi ◽  
Babak Negahdari ◽  
Ensiyeh Hajizadeh-Saffar ◽  
Mostafa Hajinasrollah ◽  
Yaser Jenab ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Receptor Agonist ◽  
Combined Therapy ◽  
Primate Model ◽  
Human Primate
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