scholarly journals Predictive value of bowel ultrasound in Crohn’s disease

2021 ◽  
Author(s):  
Xiaoying Huang ◽  
Xiaofei Li
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Predictive Value ◽  
Bowel Ultrasound

Predictive value of bowel ultrasound in Crohn’s disease: a 12-month prospective study

2021 ◽  
Author(s):  
Mariangela Allocca ◽  
Vincenzo Craviotto ◽  
Stefanos Bonovas ◽  
Federica Furfaro ◽  
Alessandra Zilli ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Prospective Study ◽  
Predictive Value ◽  
Bowel Ultrasound

Abdominal bowel ultrasound can predict the risk of surgery in Crohn's disease: Proposal of an ultrasonographic score

2009 ◽  
Vol 44 (5) ◽  
pp. 585-593 ◽  
Author(s):  
Caterina Rigazio ◽  
Elena Ercole ◽  
Cristiana Laudi ◽  
Marco Daperno ◽  
Alessandro Lavagna ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Bowel Ultrasound

scholarly journals Predictive value of tissue calprotectin for disease recurrence after ileocecal resection in pediatric Crohn's disease

2021 ◽  
Author(s):  
Kristyna Zarubova ◽  
Ondrej Fabian ◽  
Ondrej Hradsky ◽  
Tereza Lerchova ◽  
Filip Mikus ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Predictive Value ◽  
Disease Recurrence ◽  
Ileocecal Resection

scholarly journals Prevalence, significance and predictive value of antiphospholipid antibodies in Crohn’s disease

2015 ◽  
Vol 21 (22) ◽  
pp. 6952-6964 ◽  
Author(s):  
Nora Sipeki ◽  
Laszlo Davida ◽  
Eszter Palyu ◽  
Istvan Altorjay ◽  
Jolan Harsfalvi ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Predictive Value ◽  
Antiphospholipid Antibodies

scholarly journals A prospective evaluation of the predictive value of faecal calprotectin in quiescent Crohn's disease

2014 ◽  
Vol 8 (9) ◽  
pp. 1022-1029 ◽  
Author(s):  
Graham D. Naismith ◽  
Lyn A. Smith ◽  
Sarah J.E. Barry ◽  
Joanna I. Munro ◽  
Susan Laird ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Primary Endpoint ◽  
Roc Curve ◽  
Predictive Value ◽  
Clinical Relapse ◽  
Optimal Cutoff ◽  
Faecal Calprotectin ◽  
Kaplan Meier ◽  
Time To Relapse

Abstract Background Faecal calprotectin (FC) is a non-invasive marker of gastrointestinal inflammation. Aim To determine whether higher FC levels in individuals with quiescent Crohn's disease are associated with clinical relapse over the ensuing 12 months. Methods A single centre prospective study was undertaken in Crohn's disease patients in clinical remission. The receiver operating characteristic (ROC) curve for the primary endpoint of clinical relapse by 12 months, based on FC at baseline, was calculated. Kaplan–Meier curves of time to relapse were based on the resulting optimal FC cutoff for predicting relapse. Results Of 97 patients recruited, 92 were either followed up for 12 months without relapsing, or reached the primary endpoint within that period. Of these, 10 (11%) relapsed by 12 months. Median FC was lower for non-relapsers, 96 μg/g (IQR 39–237), than for relapsers, 414 μg/g (IQR 259–590), (p = 0.005). The area under the ROC curve to predict relapse using FC was 77.4%. An optimal cutoff FC value of 240 μg/g to predict relapse had sensitivity of 80.0% and specificity of 74.4%. Negative predictive value was 96.8% and positive predictive value was 27.6%, FC ≥ 240 μg/g was associated with likelihood of relapse by 12-months 12.18 (95%CI 2.55–58.2) times higher than lower values (p = 0.002). Conclusions In this prospective dataset, FC is a useful tool to help identify quiescent Crohn's disease patients at a low risk of relapse over the ensuing 12 months. FC of 240 μg/g was the optimal cutoff in this cohort.

scholarly journals Epithelial Cell Biomarkers Are Predictive of Response to Biologic Agents in Crohn’s Disease

2020 ◽  
Author(s):  
Mark T Osterman ◽  
Kelli L VanDussen ◽  
Ilyssa O Gordon ◽  
Elisabeth M Davis ◽  
Katherine Li ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Epithelial Cell ◽  
Crohn's Disease ◽  
Clinical Response ◽  
Predictive Value ◽  
Controlled Trial ◽  
Biologic Agents ◽  
Intestinal Epithelial ◽  
Randomized Controlled ◽  
Discriminant Ability

Abstract Background Therapeutic efficacy of biologics has remained at about 50% for 2 decades. In Crohn’s disease (CD) patients, we examined the predictive value of an epithelial cell biomarker, ileal microvillar length (MVL), for clinical response to ustekinumab (UST) and vedolizumab (VDZ) and its relationship to another biomarker, intestinal epithelial cell (IEC) pyroptosis, with respect to response to VDZ. Method Ileal biopsies from the UNITI-2 randomized controlled trial were analyzed for MVL as a predictor of clinical response to UST. In a 5-center academic retrospective cohort of CD patients, ileal MVL was analyzed to determine its predictive value for response to VDZ. Correlation between ileal MVL and IEC pyroptosis was determined, and the discriminant ability of the combination of 2 biomarkers to VDZ was examined. Results Clinical response in UST was significantly higher than placebo (65% vs 39%; P = 0.03), with patients with normal MVL (>1.7 µm) having the greatest therapeutic effect: 85% vs 20% (P = 0.02). For VDZ, clinical response with MVL of 1.35 to 1.55 µm was 82% vs 44% (<1.35 µm) and 40% (>1.55 µm; P = 0.038). There was no correlation between ileal MVL and IEC pyroptosis. The combination criteria of ileal pyroptosis <14 positive cells/1000 IECs or MVL of 1.35 to 1.55 µm could identify 84% of responders and 67% of nonresponders (P = 0.001). Conclusion Ileal MVL was predictive of response to UST and VDZ in prospective and retrospective CD cohorts. It was independent of ileal IEC pyroptosis, and combination of the 2 biomarkers enhanced the discriminate ability of responders from nonresponders to VDZ.

scholarly journals P308 Utility of bowel ultrasound in diagnosing disease activity in Crohn’s disease: Indian experience

2019 ◽  
Vol 13 (Supplement_1) ◽  
pp. S254-S254
Author(s):  
P Kakkadasam Ramaswamy ◽  
K V Nagarajan ◽  
A Yelsangikar ◽  
A Nagar ◽  
N Bhat
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Indian Experience ◽  
Bowel Ultrasound
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