Association between lead and cadmium co-exposure and systemic immune inflammation in residents living near a mining and smelting area in NW China

Municipal waste combustion typically involves both energy recovery as well as volume reduction of municipal solid waste prior to landfilling. However, due to environmental concerns, municipal waste combustion (MWC) has not been a widely accepted practice. A primary concern is the leaching behavior of MWC ash when it is stored in a landfill. The ash consists of a finely divided fly ash fraction (10% by volume) and a coarser bottom ash (90% by volume). Typically, MWC fly ash fails tests used to evaluate leaching behavior due to high amounts of soluble lead and cadmium species. The focus of this study was to identify specific lead bearing phases in MWC fly ash. Detailed information regarding lead speciation is necessary to completely understand the leaching behavior of MWC ash.

Download Full-text

Review for "A new Carboniferous–Permian intra-oceanic subduction system in the North Tianshan (NW China): Implications for multiple accretionary tectonics of the southern Altaids"

10.1002/gj.3787/v2/review1 ◽

2020 ◽

Keyword(s):

Nw China ◽

The North ◽

Subduction System

Download Full-text

Review for "A new Carboniferous–Permian intra-oceanic subduction system in the North Tianshan (NW China): Implications for multiple accretionary tectonics of the southern Altaids"

10.1002/gj.3787/v1/review2 ◽

2019 ◽

Keyword(s):

Nw China ◽

The North ◽

Subduction System

Download Full-text

Review for "Anisian granodiorites and mafic microgranular enclaves in the eastern Kunlun Orogen, NW China: Insights into closure of the eastern Paleo-Tethys"

10.1002/gj.3814/v2/review1 ◽

2020 ◽

Author(s):

Bin Liu

Keyword(s):

Nw China ◽

Microgranular Enclaves ◽

Mafic Microgranular Enclaves

Download Full-text

Polymorphism of p-450 cytochrome detoxication genes in adolescents depending on the degree of contamination of the organism by heavy metals

Hygiene and Sanitation ◽

10.33029/0016-9900-2020-99-5-478-482 ◽

2020 ◽

Vol 99 (5) ◽

pp. 478-482

Author(s):

N. P. Setko ◽

A. G. Setko ◽

Ekaterina V. Bulycheva ◽

A. V. Tyurin ◽

E. Yu. Kalinina

Keyword(s):

Heavy Metals ◽

Environmental Factors ◽

Heavy Metal Contamination ◽

Atomic Absorption Spectrophotometry ◽

The Body ◽

Lead And Cadmium ◽

Cyp2b6 Gene ◽

Cytochrome P 450 ◽

Gene Cyp1a1 ◽

Group 1

Introduction. Changes in the body of children and adolescents aimed at adapting to environmental factors are determined by genetic polymorphism in xenobiotic biotransformation genes, determining the degree of susceptibility of the child’s body to pollutants, which is the basis of modern personalized preventive medicine when managing risks to the health of the child population under the influence of environmental factors. Material and methods. Trace elements, including heavy metals, lead and cadmium, were determined in the hair of 256 practically healthy teenagers by atomic absorption spectrophotometry. Depending on the level of content of the latter, two groups of adolescents were formed to determine six genes of the cytochrome P-450 family. Group 1 consisted of adolescents whose cadmium lead content exceeded the average Russian indices. The second group included adolescents whose heavy metals were above the level of average Russian standards. Results. Studies have shown that in adolescents of the 1st group, compared with the data of adolescents of the 2nd group, an increase in the number of carriers of two mutant alleles at the locus rs 1048943 (gene CYP1A1) is 3.08 times, rs 464621 (gene CYP1A1) is 1. 8 times; locus rs 2069522 (CYP1A2 gene) 3.63 times; locus rs 1799853 (CYP2C9 * 2 gene) 4.5 times; locus rs 1057910 (gene CYP2C9 * 3) 3.8 times and locus rs 2279343 (gene CYP2B6) 4.25 times. Moreover, carriers of two normal alleles in adolescents of the first group at the locus rs 1048943 (gene CYP1A1) were 5.14 times; locus rs 2279343 (CYP2B6 gene) was 6.5 fold less than among adolescents of the 2nd group; and at the locus rs 464621 (gene CYP1A1), rs 2069522 (gene CYP1A2), rs 1799853 (gene CYP2C9 * 2), rs 1057910 (gene CYP2C9 * 3) there were no carriers of normal homozygotes. Conclusion. Group 1 adolescents with heavy metal contamination of the body are carriers significantly in a greater number of pathological mutations in the genes of the cytochrome P-450 detoxification system in comparison with data from group 2 adolescents.

Download Full-text