scholarly journals A NOVEL AIRWAY STENT COATING TO REDUCE MUCOUS IMPACTION

CHEST Journal ◽  
2021 ◽  
Vol 160 (4) ◽  
pp. A55
Author(s):  
Vidhu Pandey ◽  
Koji Kadowaki ◽  
Daniel Glumac ◽  
Leslie Kent ◽  
Ryan Hunter ◽  
...  
Keyword(s):  
2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Zong-Ming Li ◽  
De-Chao Jiao ◽  
Xin-Wei Han ◽  
Hui-Bin Lu ◽  
Ke-Wei Ren ◽  
...  

Abstract Background Long-term placement of airway stents has a high probability of restenosis of the airway due to granulation tissue hyperplasia, and it is difficult to remove the stent. Our aim is to evaluate the success rate and complications of removal of tracheal tube metallic stents under fluoroscopic guidance, and to compare the difference between uncovered stent and covered stent. Methods We retrospectively reviewed 45 cases (31 males and 14 females; age, 12–71 years) of tracheal metallic stent removal performed at our center between January 2014 and December 2019. Covered stents were applied in 36 cases, and uncovered stents were applied in 9 cases. In the covered stent group, 15 patients presented with granulation tissue at both ends; 3 cases, with stent fracture; and 2, with stent intolerance due to severe airway foreign body sensation. In the uncovered stents group, all patients presented with granulation tissue formation; 2 patients, with stent fracture; and 1 patient, with stent intolerance. Results A total of 41 (91.1%) stents were successfully removed (34 [94.4%] in the covered stent group and 7 [77.8%] in the uncovered stent group). The average duration of stent placement was 3.2 ± 0.7 and 2.5 ± 1.2 months in the covered stent group and uncovered stent group, respectively. With regard to the complications, hemoptysis occurred in 4 cases (average blood volume lost, 100 ml), tracheal mucosa tear occurred in 5 cases, tracheal collapse requiring emergency airway stent placement occurred in 1 case, and tracheal rupture requiring emergency surgical suture occurred in 1 case. No procedure-related deaths occurred in either group. Conclusions It is safe to remove the metal stent of the tracheal tube under the guidance of fluoroscopy, with low complications, and can avoid the long-term placement of the airway stent.


Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1165
Author(s):  
Zhanna K. Nazarkina ◽  
Boris P. Chelobanov ◽  
Konstantin A. Kuznetsov ◽  
Alexey V. Shutov ◽  
Irina V. Romanova ◽  
...  

It was previously shown that polycaprolactone (PCL)-based electrospun-produced paclitaxel (PTX)-enriched matrices exhibit long-term drug release kinetics and can be used as coatings for drug-eluting stents (DES). The installation of vascular stents involves a twofold increase in stent diameter and, therefore, an elongation of the matrices covering the stents, as well as the arterial wall in a stented area. We studied the influence of matrix elongation on its structure and PTX release using three different electrospun-produced matrices. The data obtained demonstrate that matrix elongation during stent installation does not lead to fiber breaks and does not interfere with the kinetics of PTX release. To study PTX diffusion through the expanded artery wall, stents coated with 5%PCL/10%HSA/3%DMSO/PTX and containing tritium-labeled PTX were installed into the freshly obtained iliac artery of a rabbit. The PTX passing through the artery wall was quantified using a scintillator β-counter. The artery retained the PTX and decreased its release from the coating. The retention of PTX by the arterial wall was more efficient when incubated in blood plasma in comparison with PBS. The retention/accumulation of PTX by the arterial wall provides a prolonged drug release and allows for the reduction in the dose of the drugs in electrospun-produced stent coatings.


2003 ◽  
Vol 14 (8) ◽  
pp. 545-555 ◽  
Author(s):  
Koen J. Salu ◽  
Yanming Huang ◽  
Johan M. Bosmans ◽  
Xiaoshun Liu ◽  
Shengqiao Li ◽  
...  

2010 ◽  
Vol 56 (4) ◽  
pp. 272-277 ◽  
Author(s):  
Joanna J. Wykrzykowska ◽  
Scot Garg ◽  
Chrysafios Girasis ◽  
Ton de Vries ◽  
Marie-Angele Morel ◽  
...  

Surgery Today ◽  
2010 ◽  
Vol 40 (4) ◽  
pp. 315-320 ◽  
Author(s):  
Kinya Furukawa ◽  
Junzo Ishida ◽  
Gaku Yamaguchi ◽  
Jitsuo Usuda ◽  
Hidemitsu Tsutsui ◽  
...  

2017 ◽  
Vol 32 (4) ◽  
pp. 429-442 ◽  
Author(s):  
Gang Zhou ◽  
Qianyi Han ◽  
Jun Tai ◽  
Beibei Liu ◽  
Jing Zhang ◽  
...  

Recently, more and more researchers have focused on airway stent applied in tracheomalacia. The airway stents for clinical application were usually manufactured in accordance with a fixed pattern, which were difficult to perfect match with children, especially infants. Digital light procession of light curing acrylate resin implantation showed higher accuracy and printing speed over traditional three-dimensional printing techniques. In this article, a novel personalized airway stent was developed by digital light procession three-dimensional printing and was modified by collagen I extracted from the fish scales. The morphology of the collagen-modified airway stent was examined by scanning electron microscopy, and the chemical structures were examined by attenuated total internal reflectance Fourier transform infrared spectroscopy. The biocompatibility of this synthetic acrylate/collagen composite airway stent was characterized by water contact angle test and cell culture. The results confirmed that the composite airway stent was hydrophilic and non-cytotoxic toward a cultured human bronchial epithelial cell line with good cell viability and show excellent physicochemical and biological properties. In conclusion, this study presented the three-dimensional printing composite acrylate and collagen airway stent may have potential in customized treatment for tracheomalacia.


2015 ◽  
Vol 51 (6) ◽  
pp. 607-612 ◽  
Author(s):  
Juan L. Antón-Pacheco ◽  
Carmen Luna ◽  
Enrique García ◽  
María López ◽  
Rocío Morante ◽  
...  

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