scholarly journals Influence of Elongation of Paclitaxel-Eluting Electrospun-Produced Stent Coating on Paclitaxel Release and Transport Through the Arterial Wall after Stenting

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1165
Author(s):  
Zhanna K. Nazarkina ◽  
Boris P. Chelobanov ◽  
Konstantin A. Kuznetsov ◽  
Alexey V. Shutov ◽  
Irina V. Romanova ◽  
...  
Keyword(s):  
Drug Release ◽  
Arterial Wall ◽  
Release Kinetics ◽  
Artery Wall ◽  
Vascular Stents ◽  
Drug Eluting ◽  
Fiber Breaks ◽  
Stent Diameter ◽  
Stent Coating

It was previously shown that polycaprolactone (PCL)-based electrospun-produced paclitaxel (PTX)-enriched matrices exhibit long-term drug release kinetics and can be used as coatings for drug-eluting stents (DES). The installation of vascular stents involves a twofold increase in stent diameter and, therefore, an elongation of the matrices covering the stents, as well as the arterial wall in a stented area. We studied the influence of matrix elongation on its structure and PTX release using three different electrospun-produced matrices. The data obtained demonstrate that matrix elongation during stent installation does not lead to fiber breaks and does not interfere with the kinetics of PTX release. To study PTX diffusion through the expanded artery wall, stents coated with 5%PCL/10%HSA/3%DMSO/PTX and containing tritium-labeled PTX were installed into the freshly obtained iliac artery of a rabbit. The PTX passing through the artery wall was quantified using a scintillator β-counter. The artery retained the PTX and decreased its release from the coating. The retention of PTX by the arterial wall was more efficient when incubated in blood plasma in comparison with PBS. The retention/accumulation of PTX by the arterial wall provides a prolonged drug release and allows for the reduction in the dose of the drugs in electrospun-produced stent coatings.

scholarly journals Long-term benefit-risk balance of drug-eluting vs. bare-metal stents in daily practice: does stent diameter matter? Three-year follow-up of BASKET

2008 ◽  
Vol 30 (1) ◽  
pp. 16-24 ◽  
Author(s):  
M. Pfisterer ◽  
H. P. Brunner-La Rocca ◽  
P. Rickenbacher ◽  
P. Hunziker ◽  
C. Mueller ◽  
...  
Keyword(s):  
Bare Metal Stents ◽  
Daily Practice ◽  
Metal Stents ◽  
Bare Metal ◽  
Drug Eluting ◽  
Risk Balance ◽  
Stent Diameter ◽  
Term Benefit

Construction of multilayer films with bactericidal and long-term antitumor drug release properties as a non-vascular stent coating for therapy in obstruction

2019 ◽  
Vol 7 (32) ◽  
pp. 4963-4972 ◽  
Author(s):  
Xiao-yan Xu ◽  
Yan-fang Chen ◽  
Qing-gang Tan ◽  
Zhi-jie Chen ◽  
Yan Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Self Assembly ◽  
Multilayer Films ◽  
Antitumor Drug ◽  
Layer By Layer ◽  
Vascular Stent ◽  
Assembly Method ◽  
Stent Coating

An antibacterial and antitumor coating for non-vascular stent was constructed via the layer-by-layer electrostatic self-assembly method.

Controlling methacryloyl substitution of chondroitin sulfate: injectable hydrogels with tunable long-term drug release profiles

2019 ◽  
Vol 7 (13) ◽  
pp. 2151-2161 ◽  
Author(s):  
Kimberly J. Ornell ◽  
Danilo Lozada ◽  
Nhi V. Phan ◽  
Jeannine M. Coburn
Keyword(s):  
Drug Release ◽  
Chondroitin Sulfate ◽  
Release Kinetics ◽  
Injectable Hydrogels ◽  
Drug Release Kinetics ◽  
Release Profiles

Controlling the degree of methacryloyl substitution on chondroitin sulfate allows for tunable drug release kinetics.

scholarly journals Production, Characterization and Application of Oxide Nanotubes on Ti–6Al–7Nb Alloy as a Potential Drug Carrier

Materials ◽  
2021 ◽  
Vol 14 (20) ◽  
pp. 6142
Author(s):  
Bożena Łosiewicz ◽  
Agnieszka Stróż ◽  
Patrycja Osak ◽  
Joanna Maszybrocka ◽  
Anna Gerle ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Drug Release ◽  
Room Temperature ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Potential Drug ◽  
Voltage Range ◽  
Inflammatory Conditions ◽  
Drug Eluting

This work concerns the development of a method of functionalization of the surface of the biomedical Ti–6Al–7Nb alloy by producing oxide nanotubes (ONTs) with drug-eluting properties. Shaping of the morphology, microstructure, and thickness of the oxide layer was carried out by anodization in an aqueous solution of 1 M ethylene glycol with the addition of 0.2 M NH4F in the voltage range 5–100 V for 15–60 min at room temperature. The characterization of the physicochemical properties of the obtained ONTs was performed using SEM, XPS, and EDAX methods. ONTs have been shown to be composed mainly of TiO2, Al2O3, and Nb2O5. Single-walled ONTs with the largest specific surface area of 600 cm2 cm−2 can be obtained by anodization at 50 V for 60 min. The mechanism of ONT formation on the Ti–6Al–7Nb alloy was studied in detail. Gentamicin sulfate loaded into ONTs was studied using FTIR, TG, DTA, and DTG methods. Drug release kinetics was determined by UV–Vis spectrophotometry. The obtained ONTs can be proposed for use in modern implantology as carriers for drugs delivered locally in inflammatory conditions.

scholarly journals Modeling and Analysis of Drug-Eluting Stents With Biodegradable PLGA Coating: Consequences on Intravascular Drug Delivery

2014 ◽  
Vol 136 (11) ◽  
Author(s):  
Xiaoxiang Zhu ◽  
Richard D. Braatz
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Arterial Wall ◽  
Drug Distribution ◽  
Integrated Model ◽  
Drug Binding ◽  
Drug Eluting Stents ◽  
Drug Concentrations ◽  
Drug Eluting ◽  
Release Profiles

Increasing interests have been raised toward the potential applications of biodegradable poly(lactic-co-glycolic acid) (PLGA) coatings for drug-eluting stents in order to improve the drug delivery and reduce adverse outcomes in stented arteries in patients. This article presents a mathematical model to describe the integrated processes of drug release in a stent with PLGA coating and subsequent drug delivery, distribution, and drug pharmacokinetics in the arterial wall. The integrated model takes into account the PLGA degradation and erosion, anisotropic drug diffusion in the arterial wall, and reversible drug binding. The model simulations first compare the drug delivery from a biodegradable PLGA coating with that from a biodurable coating, including the drug release profiles in the coating, average arterial drug levels, and arterial drug distribution. Using the model for the PLGA stent coating, the simulations further investigate drug internalization, interstitial fluid flow in the arterial wall, and stent embedment for their impact on drug delivery. Simulation results show that these three factors, while imposing little change in the drug release profiles, can greatly change the average drug concentrations in the arterial wall. In particular, each of the factors leads to significant and yet distinguished alterations in the arterial drug distribution that can potentially influence the treatment outcomes. The detailed integrated model provides insights into the design and evaluation of biodegradable PLGA-coated drug-eluting stents for improved intravascular drug delivery.

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