Evaluation of monolithic packed 96-tips and liquid chromatography–tandem mass spectrometry for extraction and quantification of pindolol and metoprolol in human plasma samples

2008 ◽  
Vol 1196-1197 ◽  
pp. 23-27 ◽  
Author(s):  
Mohamed Abdel-Rehim ◽  
Christina Persson ◽  
Zeki Altun ◽  
Lars Blomberg
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Human Plasma ◽  
Tandem Mass ◽  
Plasma Samples ◽  
Chromatography Tandem Mass Spectrometry ◽  
Human Plasma Samples ◽  
Liquid Chromatography Tandem Mass

scholarly journals A New Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Bisoprolol in Human Plasma Samples

2009 ◽  
Vol 2009 ◽  
pp. 1-8 ◽  
Author(s):  
Gabriela Peste ◽  
Nela Bibire ◽  
Mihai Apostu ◽  
Aurel Vlase ◽  
Corneliu Oniscu
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Human Plasma ◽  
Tandem Mass ◽  
Plasma Samples ◽  
Chromatography Tandem Mass Spectrometry ◽  
Human Plasma Samples ◽  
Liquid Chromatography Tandem Mass

Liquid chromatography (LC) coupled with mass spectrometry (MS) detection is one of the most powerful analytical tools for organic compound analysis. The advantages of using LC/MS methods over HPLC methods include: selectivity, chromatographic integrity, peak assignment, structural information, and rapid method development. In this paper, a new liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination of bisoprolol in human plasma samples, using metoprolol as internal standard and liquid-liquid extraction procedure. The assay has proven to be sensitive, specific and reproducible, suitable to determine the bisoprolol concentration, following a single oral administration of a 10 mg bisoprolol tablet in 22 healthy volunteers, in the bioequivalence study of Bisoprolol 10 mg coated tablets, produced by Antibiotice S.A. versus Concor 10 mg, produced by Merck.

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