Effect of pore-size optimization on the performance of polysaccharide-based superficially porous chiral stationary phases for the separation of enantiomers in high-performance liquid chromatography

2017 ◽  
Vol 1482 ◽  
pp. 32-38 ◽  
Author(s):  
Lia Bezhitashvili ◽  
Anna Bardavelidze ◽  
Teona Ordjonikidze ◽  
Lali Chankvetadze ◽  
Mike Chity ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Pore Size ◽  
High Performance ◽  
Stationary Phases ◽  
Chiral Stationary Phases ◽  
Size Optimization ◽  
Separation Of Enantiomers

Polysaccharide derivatives as useful chiral stationary phases in high-performance liquid chromatography

2007 ◽  
Vol 79 (9) ◽  
pp. 1561-1573 ◽  
Author(s):  
Xiaoming Chen ◽  
Chiyo Yamamoto ◽  
Yoshio Okamoto
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Silica Gel ◽  
Chromatographic Separation ◽  
High Performance ◽  
Stationary Phases ◽  
Chiral Stationary Phases ◽  
Separation Of Enantiomers ◽  
Polysaccharide Derivatives ◽  
New Generation

The chromatographic separation of enantiomers using chiral stationary phases (CSPs) has significantly advanced. The esters and carbamates of polysaccharides coated on silica gel have been extensively studied and widely used as CSPs for high-performance liquid chromatography (HPLC). In order to overcome the strict solvent limitation on these coated CSPs, the preparation of a new generation of CSPs consisting of immobilized polysaccharide derivatives has become increasingly important. The universal solvent compatibility of the new CSPs provides flexibility in both analytical and preparative chromatographies.

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