Using multimodal chromatography for post-conjugation antibody-drug conjugate purification: A methodology from high throughput screening to in-silico process development

2021 ◽  
pp. 462378
Author(s):  
William R. Keller ◽  
Michaela Wendeler
Keyword(s):  
High Throughput ◽  
In Silico ◽  
High Throughput Screening ◽  
Process Development ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Multimodal Chromatography ◽  
Antibody Drug

Kinetic reaction modeling for antibody-drug conjugate process development

2019 ◽  
Vol 306 ◽  
pp. 71-80 ◽  
Author(s):  
Sebastian Andris ◽  
Jonathan Seidel ◽  
Jürgen Hubbuch
Keyword(s):  
Process Development ◽  
Antibody Drug Conjugate ◽  
Kinetic Reaction ◽  
Drug Conjugate ◽  
Antibody Drug

Process Development and Structural Characterization of an Anti-Notch 3 Antibody–Drug Conjugate

2018 ◽  
Vol 22 (3) ◽  
pp. 286-295 ◽  
Author(s):  
Durgesh V. Nadkarni ◽  
Qingping Jiang ◽  
Olga Friese ◽  
Nataliya Bazhina ◽  
He Meng ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Process Development ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Notch 3 ◽  
Antibody Drug

High-Throughput Platform to Identify Antibody Conjugation Sites from Antibody–Drug Conjugate Libraries

2020 ◽  
Vol 31 (4) ◽  
pp. 1199-1208 ◽  
Author(s):  
Sayumi Yamazoe ◽  
Jason M. Hogan ◽  
Sean M. West ◽  
Xiaodi A. Deng ◽  
Srikanth Kotapati ◽  
...  
Keyword(s):  
High Throughput ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Antibody Conjugation ◽  
Antibody Drug

scholarly journals High-Throughput, Multispecies, Parallelized Plasma Stability Assay for the Determination and Characterization of Antibody–Drug Conjugate Aggregation and Drug Release

ACS Omega ◽  
2017 ◽  
Vol 2 (8) ◽  
pp. 4207-4215 ◽  
Author(s):  
Kenneth R. Durbin ◽  
M. Shannon Nottoli ◽  
Nathaniel D. Catron ◽  
Nicole Richwine ◽  
Gary J. Jenkins
Keyword(s):  
Drug Release ◽  
High Throughput ◽  
Plasma Stability ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Antibody Drug
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