Comparison of the efficacy of eyelid warming masks and artificial tears for dry eye symptoms in contact lens wearers

Abstract Dry eye disease (DED) is a multifactorial ocular surface disease. The commonest treatment is artificial tears. A novel artificial tears is urgently required to treat DED pathophysiologically, more than symptoms relief. In this study, a novel artificial tears with highly purified recombinant human lysozyme (rhLYZ), high homologous with natural tear, was obtained for DED treatment on a established rabbit DED model. 36 models were divided into 6 groups (n = 6), and treated with different concentration of novel artificial tears 180µl of drops daily, continuously for 4 weeks. To evaluate pathophysiologic therapeutic effect of the novel artificial tears, rabbit eyes were performed to the schirmer I test, tear ferning test, and corneal fluorescein staining test in 0, 1, 2, 3 and 4 weeks post-administration, respectively. The sacrificed models' corneas in 4 weeks were performed by pathological section staining. In the project, the quality of the artificial tears including rhLYZ was up to the quality standards of pharmacopoeia. RhLYZ eye drops, especially in the medium (0.15% of rhLYZ) and the high(0.30% of rhLYZ) concentration, enable to improve dry eye symptoms effectively, benefit to anti-inflammatory function and promote corneal repair. The novel artificial tears is a promising pathophysiological therapeutic agent in DED treatment.

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A Novel Method to Predict the Dry Eye Symptoms in New Contact Lens Wearers

Optometry and Vision Science ◽

10.1097/opx.0b013e3181b598cd ◽

2009 ◽

Vol 86 (9) ◽

pp. E1042-E1050 ◽

Cited By ~ 58

Author(s):

Heiko Pult ◽

Paul J. Murphy ◽

Christine Purslow

Keyword(s):

Dry Eye ◽

Contact Lens ◽

Eye Symptoms ◽

Novel Method ◽

Dry Eye Symptoms

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My Tattoos Caused My Dry Eye?

Canadian Journal of Optometry ◽

10.15353/cjo.78.466 ◽

2016 ◽

Vol 78 (2) ◽

pp. 6 ◽

Cited By ~ 1

Author(s):

Caitlin J Morrison ◽

Joseph M Stamm

Keyword(s):

Case Report ◽

Dry Eye ◽

Meibomian Gland ◽

Artificial Tears ◽

Tattoo Pigment ◽

Eye Symptoms ◽

Meibomian Glands ◽

Potential Impact ◽

And Function ◽

Dry Eye Symptoms

Purpose: This case report describes the potential impact of tattooed eyeliner on eyelid structure and function resulting in an increase in dry eye symptoms and findings. Case Report: A 59-year-old Hispanic female presented for an evaluation following longstanding dry eye symptoms with little relief from artificial tears. Imaging showed meibomian gland dropout, possibly a result of her tattooed eyeliner. Symptoms and objective measurements improved successfully with warm compresses, lid massage, and lipid-based artificial tears. Conclusions. Permanent tattooed eyeliner may enhance dryness of the eyes in two main ways: disruption of the architecture of the lids and chronic inflammation from tattoo pigment granules. Recognizing these possible effects in patients with tattooed eyeliner may help tailor treatment to be specific to the etiology of the patient’s dry eye: aiding the remaining meibomian glands by utilizing warm compresses, lid massage and supplementing the lipid from the missing meibomian glands by employing lipid-based artificial tears.

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Folded bandage contact lens retention in a patient with bilateral dry eye symptoms: a case report

BMC Ophthalmology ◽

10.1186/s12886-017-0505-4 ◽

2017 ◽

Vol 17 (1) ◽

Cited By ~ 3

Author(s):

Derek K.-H. Ho ◽

John P. Mathews

Keyword(s):

Case Report ◽

Dry Eye ◽

Contact Lens ◽

Bandage Contact Lens ◽

Eye Symptoms ◽

Dry Eye Symptoms

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Tear Film Evaluation in Contact Lens Wearers and Non Wearers

Journal of Institute of Medicine ◽

10.3126/jiom.v34i2.9045 ◽

2013 ◽

Vol 34 (2) ◽

pp. 14-20

Author(s):

GS Shrestha ◽

D Sujakhu ◽

JB Shrestha ◽

JK Shrestha

Keyword(s):

Dry Eye ◽

Contact Lens ◽

Tear Film ◽

Subjective Assessment ◽

Institute Of Medicine ◽

Non Invasive ◽

Function Tests ◽

Eye Symptoms ◽

Break Up ◽

Dry Eye Symptoms

Background: Dry eye symptoms are more frequent in contact lens wearers than in non wearers. Dry eye is considered relatively common in contact lens wearers than non-wearers. However, there was no any report in our clinical setting that compared and addressed the issue related to dry eye and its symptom in contact lens wearers. The present study was conducted to compare pre-ocular tear lm in contact lens wearers (CLW) and contact lens non wearers (CLNW), and evaluate the relationship between clinical and subjective assessment of dry eye symptoms. Methods: It was a comparative study conducted among 131 subjects (262 eyes) attended in the contact lens clinic at BP Koirala Lions Center for the Ophthalmic Studies. Sixty five were daily soft contact lens wearers; sixty-six were non wearers. Tear function assessment included non- invasive tear break up time, invasive tear break up time, tear prism height and Schirmer II test. Subjective assessment of dry eye symptoms was carried out using McMonnies questionnaires. Results: Mean age of CLNW was 23.01± 5.53 and CLW was 23.6± 4.61. Female (89 subjects) visited more than male (42 subjects) in contact lens clinic. Mean symptom score in CLW was significantly higher than CLNW (p<0.001). But, distribution of symptomatology was not significantly different in both groups. Symptomatic subjects were elder (p<0.001) and female (p<0.05) in CLNW and only elder subjects in CLW. Tear function tests were significantly lower in symptomatic subjects in CLW and CLNW; Overall tear function test scores were also lower in CLW than CLNW. Tear function tests scores were insignificantly different in male and female. Coefficient of correlation was positive and weak for all tear function tests scores. Conclusions: Though, tear function tests scores were reduced in CLW than CLNW, dry eye symptomatology was almost similar. Subjective assessment of symptoms is as important as clinical tests. DOI: http://dx.doi.org/10.3126/joim.v34i2.9044 Journal of Institute of Medicine August, 2012; 34:2 14-20

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