Comparative Survival of Patients With Anal Adenocarcinoma, Squamous Cell Carcinoma of the Anus, and Rectal Adenocarcinoma

2016 ◽  
Vol 15 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Robert A. Franklin ◽  
Smith Giri ◽  
Poojitha Valasareddy ◽  
Lindsey T. Lands ◽  
Mike G. Martin
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Rectal Adenocarcinoma ◽  
Anal Adenocarcinoma

scholarly journals A Case of Rectal Squamous Cell Carcinoma Mistaken for Rectal Adenocarcinoma

2014 ◽  
Vol 29 (2) ◽  
pp. 157
Author(s):  
Jung Ik Park ◽  
Ung Seok Yang ◽  
Sung Won Moon ◽  
Oun Ouk Nam ◽  
Hyo Jong Kim ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Rectal Adenocarcinoma

Patterns of Care and Comparison of Outcomes Between Primary Anal Squamous Cell Carcinoma and Anal Adenocarcinoma

2019 ◽  
Vol 62 (12) ◽  
pp. 1448-1457 ◽  
Author(s):  
Nikita Malakhov ◽  
Ami M. Kavi ◽  
Anna Lee ◽  
Paul Adedoyin ◽  
Niki Sheth ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Patterns Of Care ◽  
Anal Squamous Cell Carcinoma ◽  
Anal Adenocarcinoma

scholarly journals Association of Age With Tumor Grade in Patients With Digestive Tumors: A Study Based on US SEER Registry

2020 ◽  
Author(s):  
Yange Zhang ◽  
Wei Li
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Pancreatic Adenocarcinoma ◽  
Squamous Cell ◽  
Rectal Adenocarcinoma ◽  
Tumor Grade ◽  
Regression Analyses ◽  
Anal Squamous Cell Carcinoma ◽  
Piecewise Regression ◽  
The Relationship

Abstract Background: Previous studies have not demonstrated an independent association of age and tumor grade. In this study, we aimed to explore the relationship between age and tumor grade (differentiation) in patients with digestive tumors.Methods: Surveillance, Epidemiology and End Results (SEER) 18 registry database for 1973 through 2015 was retrieved for the present study. Both piecewise and non-piecewise linear regression model were utilized to examine the relationship between age and tumor grade. Results: The present study included a total of 938,145 patients with 13 types of primary malignancies of the digestive system. In non-piecewise regression analyses, older age was associated with higher tumor grades in patients with esophageal squamous cell carcinoma (P < 0.0001) and anal squamous cell carcinoma (P < 0.0001). In contrast, older age was related to lower tumor grades in patients with esophageal adenocarcinoma (P = 0.0177), gastric adenocarcinoma (P < 0.0001), pancreatic adenocarcinoma (P < 0.0001) and rectal adenocarcinoma (P < 0.0001). In piecewise regression analyses, positive associations of age and tumor grade were only observed in specific age groups in some types of tumor, e.g., anal adenocarcinoma (> 66 years), gallbladder adenocarcinoma (> 49 years), pancreatic adenocarcinoma (> 56 years), hepatocellular carcinoma (35-90 years), rectal adenocarcinoma (<59 years in White; < 52 years in Non-White) and anal squamous cell carcinoma (<51 years in White; < 58 years in Non-White). Patients with well-differentiated tumors had better long-term prognoses compared to those with poorly-differentiated tumors (all P < 0.05). Conclusion: The patterns of relationship between age and tumor grade were different in patients with different types of digestive tumor, which may be a reflection of the distinct molecular subtypes of these tumors.

Comparison of survival outcomes of rectal squamous cell carcinoma with rectal adenocarcinoma.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 745-745
Author(s):  
Chi Lin ◽  
Abhijeet Bhirud ◽  
Jinluan Li ◽  
Mary E. Charlton
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumor Size ◽  
Proportional Hazards ◽  
Early Stage ◽  
Rectal Adenocarcinoma ◽  
Cox Proportional Hazards ◽  
Entire Group

745 Background: Rectal squamous cell carcinoma (RSCC) is a rare disease. It is unclear whether the prognosis or treatment outcomes differ from that of rectal adenocarcinoma (RAC). The objective of this study is to compare the overall survival (OS), cancer specific survival (CSS) and prognostic factors of RSCC to those of rectal adenocarcinoma (RAC) using the Surveillance, Epidemiology, and End Results (SEER) registry. Methods: A total of 42,317 patients diagnosed with RSCC (999) and RAC (41,318) without distant metastasis between 1998 and 2011 were identified from the SEER database. Factors analyzed included histology (RSCC/RAC), age (≤56/>56), gender, race (white/nonwhite), tumor size (<5 cm/≥5 cm), grade (well-moderate/poor-undifferentiated), stage (local/regional), year of diagnosis (1998-2003/2004-2011), with or without surgery, and with or without radiotherapy (RT). OS and CSS were evaluated using the Kaplan-Meier method. Cox proportional hazards regression analysis was performed to examine the prognostic factors for survival. Results: The median follow up is 77 months (M). The entire group had 5 year OS and CSS of 62% and 77% with a median OS of 95 M but did not reach a median CSS. Compared to patients with RAC, patients with RSCC tend to be younger, female, diagnosed more recently, with less advanced stage but higher grade and larger tumor size. For patients with RSCC, 40% underwent surgery and 75% received RT. In contrast, for patients with RAC, 89% underwent surgery and 59% received RT. Patients with RSCC had a higher median OS than those with RAC (105 vs 94 M, Log-rank p <0.05). Cox proportional hazards analysis showed that patients with RAC had worse OS (hazard ratio [HR] 1.4) and CSS (HR 1.6) than patients with RSCC (p<0.05), after adjusting for all prognostic factors. Factors associated with improved OS and CSS in both RSCC and RAC included age ≤56, nonwhite, early stage, well-moderate differentiated, undergoing surgery and receiving RT. Gender is a prognostic factor for OS but not for CSS. Conclusions: Patients with rectal squamous cell carcinoma had a significantly superior OS and CSS than patient with rectal adenocarcinoma. Future studies should seek to explore the optimal management for these two distinct diseases.

scholarly journals PERINEAL REPAIR AFTER ABDOMINOPERINEAL EXCISION WITH RECTUS ABDOMINIS MYOCUTANEOUS FLAP

2020 ◽  
Vol 33 (2) ◽  
Author(s):  
Elsa D’ANNUNZIO ◽  
Alain VALVERDE ◽  
Renato Micelli LUPINACCI
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Rectal Adenocarcinoma ◽  
Posterior Wall ◽  
Abdominoperineal Excision ◽  
Rectus Abdominis ◽  
Reconstruction Method ◽  
Epigastric Artery ◽  
Perineal Defect

ABSTRACT Background: Abdominoperineal excision of the rectum (APR) remains the only potential curative treatment for very low rectal adenocarcinoma and squamous cell carcinoma of the anus. Yet, it implies a significant perineal exenteration and has set the attention on the perineal reconstruction. Aim: To present technique used in one case of APR for anal cancer, with resection of the vaginal posterior wall with large perineal defect which has called for the necessity of a flap for reconstruction Method: To cover the large perineal defect and reconstruct the posterior vaginal wall was perform a standardized and reproducible surgical technique using oblique rectus abdominis myocutaneous (ORAM) flap. The overlying skin of this flap is thick and well vascularized by both superficial branches and perforators of the superior epigastric artery and the deep inferior epigastric artery which serves as the vascular pedicle for the ORAM flap. Results: This procedure was applied in a 65-year-old woman with recurrent squamous cell carcinoma of the anus infiltrating the posterior wall of the vagina. Was performed an APR with en-bloc resection of the vaginal posterior wall in order to achieve tumor-free margins. Postoperative course was uneventful and she was discharged home at postoperative day 9. Final pathological report confirmed the oncological adequacy of the procedure (R0) and showed a rypT4N0 lesion. Conclusion: Flap reconstruction is an effective way to cover the perineal wound reducing both perineal complication rate and wound healing delay. The ORAM is particularly interesting for female whose tumors require resection and subsequent reconstruction of the posterior wall of the vagina.

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