Long-Term Follow-Up Using Testicle-Sparing Surgery for Leydig Cell Tumor

Gynecomastia is a common incidental finding in males that can be caused by various benign or malignant diseases. In rare cases, it results from Leydig cell tumors, a rare entity accounting for 3% of all testicular neoplasms. Some of them are hormonally active but seldom cause symptomatic endocrine disturbance. Here we report on a 32-year-old male presenting with gynecomastia which he had already been suffering from for two years. Although he had been seen by three other specialists, including a urologist, none of them found the small mass in the upper pole of his right testis. We decided to perform testis-sparing surgery which confirmed the diagnosis of a hormonally active Leydig cell tumor. During follow-up, hormonal status normalized, and gynecomastia began to resolve.

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6 TESTICULAR IRRADIATION (TI) FOR ACUTE LYMPHOBLASTIC LEUKEMIA (ALL): LONG TERM FOLLOW-UP OF LEYDIG CELL FUNCTION AND PUBERTAL DEVELOPMENT

Pediatric Research ◽

10.1203/00006450-198810000-00027 ◽

1988 ◽

Vol 24 (4) ◽

pp. 518-518

Author(s):

R Brauner ◽

P Caltabiano ◽

R Rappaport ◽

G Leverger ◽

G Schaison

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Leydig Cell ◽

Cell Function ◽

Lymphoblastic Leukemia ◽

Pubertal Development ◽

Long Term Follow Up ◽

Leydig Cell Function

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Extragonadal Intraabdominal Mixed Germ Cell Tumor with Liver Metastasis: Successful Treatment and Long-term Follow-up

Journal of the Korean Association of Pediatric Surgeons ◽

10.13029/jkaps.2013.19.1.25 ◽

2013 ◽

Vol 19 (1) ◽

pp. 25

Author(s):

Jinyoung Park

Keyword(s):

Liver Metastasis ◽

Germ Cell ◽

Germ Cell Tumor ◽

Successful Treatment ◽

Cell Tumor ◽

Mixed Germ Cell Tumor ◽

Long Term Follow Up

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A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-term follow-up

Human Pathology ◽

10.1016/j.humpath.2010.08.008 ◽

2011 ◽

Vol 42 (5) ◽

pp. 727-733 ◽

Cited By ~ 14

Author(s):

Tsuyoshi Saito ◽

Hiroyuki Mitomi ◽

Hiroshi Izumi ◽

Yoshiyuki Suehara ◽

Taketo Okubo ◽

...

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

P53 Mutation ◽

Cell Tumor ◽

Long Term Follow Up ◽

Malignant Giant Cell Tumor

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GCT-36. TREATMENT RESULTS AND RADIATION-INDUCED TUMORS IN CASES OF CENTRAL NERVOUS SYSTEM GERM CELL TUMOR: A LONG-TERM FOLLOW-UP STUDY IN KUMAMOTO PREFECTURE

Neuro-Oncology ◽

10.1093/neuonc/noaa222.255 ◽

2020 ◽

Vol 22 (Supplement_3) ◽

pp. iii335-iii335

Author(s):

Takahiro Yamamoto ◽

Keishi Makino ◽

Hideo Nakamura ◽

Jun-ichiro Kuroda ◽

Takashi Itoyama ◽

...

Keyword(s):

Pediatric Brain Tumors ◽

Cell Tumor ◽

The Past ◽

Induced Tumors ◽

Long Term Follow Up ◽

Radiation Induced ◽

Pediatric Brain ◽

Radiation Induced Tumors

Abstract INTRODUCTION Central nervous system germ cell tumor (GCT) is one of the pediatric brain tumors. Although there have been epidemiological studies in the past, long-term prognosis and the late effects remained unclear. In this study, we examined GCT over the past 41 years in Kumamoto prefecture. METHODS Epidemiological features and complications with radiation-induced tumors were searched in patients diagnosed with GCT in the 41-year period from 1977 to 2018. RESULTS There were 93 patients diagnosed with GCT. These cases were divided into 14-year periods before and after incorporation of chemotherapy into the treatment, and the results for germinomas were compared. An improvement in the 10-year survival rate from 12 of 23 cases (52.2%) between 1977 and 1991 to 19 of 28 cases (67.9%) between 1992 and 2006 was observed. The 10-year survival rate for germinoma cases that received medical treatment during a more recent 5-year period between 2004 and 2009 increased to over 90%. However, 10.3% of all long-term survivors of GCT developed radiation-induced glioblastoma. The examination results showed that regardless of the tumor type, patients who received a high dose of radiation during their initial treatment developed the complication of radiation-induced glioblastoma within 10 to 25 years after their initial treatment. CONCLUSION This study suggests that the long-term survival rates for GCT are improving but the rate of radiation-induced glioblastoma in these cases are too high to be ignored. Long-term follow-up of at least 10 years is essential to effectively evaluate the details of treatment for pediatric brain tumors.

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