scholarly journals Two Years of Gynecomastia Caused by Leydig Cell Tumor

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Philip Zeuschner ◽  
Christian Veith ◽  
Johannes Linxweiler ◽  
Michael Stöckle ◽  
Julia Heinzelbecker
Keyword(s):  
Leydig Cell ◽  
Incidental Finding ◽  
Small Mass ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Hormonal Status ◽  
Rare Entity ◽  
Endocrine Disturbance ◽  
Leydig Cell Tumors

Gynecomastia is a common incidental finding in males that can be caused by various benign or malignant diseases. In rare cases, it results from Leydig cell tumors, a rare entity accounting for 3% of all testicular neoplasms. Some of them are hormonally active but seldom cause symptomatic endocrine disturbance. Here we report on a 32-year-old male presenting with gynecomastia which he had already been suffering from for two years. Although he had been seen by three other specialists, including a urologist, none of them found the small mass in the upper pole of his right testis. We decided to perform testis-sparing surgery which confirmed the diagnosis of a hormonally active Leydig cell tumor. During follow-up, hormonal status normalized, and gynecomastia began to resolve.

scholarly journals Leydig cell tumor of testis- a rare case report

2017 ◽  
Vol 4 (11) ◽  
pp. 3795
Author(s):  
Sheetal Arora ◽  
Mukta Pujani ◽  
Deepshikha Rana ◽  
Narendra Chaudhaury
Keyword(s):  
Leydig Cell ◽  
Histopathological Examination ◽  
Young Patients ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Positive Staining ◽  
Historical Series ◽  
Endocrine Profile ◽  
Leydig Cell Tumors

Leydig cell tumors(LCTs) of testis are rare testicular tumors of male gonadal interstitium. Although rare, they are most common sex cord stromal tumors and comprise 1-3 % of all testicular neoplasms. They usually occur in fourth to sixth decade. In young patients, they are mostly benign and in adults it can be malignant in about 10 % cases. The incidence of Leydig cell tumors is gradually increasing every year which might be attributed to increased use of radiological techniques and subsequent early detection of tumors that have not been found in historical series. Here we report a case of benign Leydig cell tumor testis in a 45-year-old male who presented with left sided testicular mass. The patient subsequently underwent high inguinal orchidectomy. Histopathological examination showed benign pure Leydig cell tumor. Serological investigations revealed normal testosterone levels, DHEA and androstenedione levels. Immunohistochemical staining for inhibin showed fine granular cytoplasmic positivity and diffuse positive staining for Melan-A which further confirmed the diagnosis. The endocrine profile and imaging investigations of such patients might be normal and patients can be totally asymptomatic. However periodic follow up of endocrine profile and imaging must be done as many cases have been reported which had deranged endocrine levels and appearance of atypical symptoms even after years of unilateral orchidectomy. Our case also presents with normal hormonal levels, henceforth for a better prognosis we must identify benign LCTs and do long term follow up.

Cytologic Identification of Reinke Crystalloids in Scrapings and Imprints of Fresh Testicular Tumors: A Simple and Rapid Technique for Intraoperative Use

2005 ◽  
Vol 129 (3) ◽  
pp. e65-e66 ◽  
Author(s):  
Kambridge P. Hribar ◽  
Nancy E. Warner ◽  
Andy E. Sherrod
Keyword(s):  
Leydig Cell ◽  
Leydig Cells ◽  
Frozen Section ◽  
Rapid Identification ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Testicular Tumors ◽  
Intraoperative Diagnosis ◽  
Rapid Technique ◽  
Leydig Cell Tumors

Abstract Although not required for the diagnosis, crystalloids of Reinke are pathognomonic for Leydig cell tumor. However, conventional frozen section rarely reveals their presence. A method of rapid identification of crystalloids of Reinke could improve the intraoperative diagnosis. We tested the efficacy of touch imprints and scrape smears for the identification of crystalloids in 2 cases of Leydig cell tumor of the testis. Intraoperative smears of the tumors yielded abundant crystals. Scrape cytologic testing was the better method. We speculate that the process of scraping, and to a lesser extent touch imprinting, disrupts the cytoplasm of the Leydig cells and releases the crystalloids. We conclude that cytologic testing is an effective method of identifying crystalloids of Reinke in Leydig cell tumors of the testis.

scholarly journals Retiform Sertoli-Leydig Cell Tumor in a 38-Year-Old Woman: A Case Report, Retrospective Review, and Review of Current Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Laura C. Nwogu ◽  
Josh A. Showalter ◽  
Suvra Roy ◽  
Michael T. Deavers ◽  
Bihong Zhao
Keyword(s):  
Leydig Cell ◽  
Stromal Cells ◽  
Ovarian Neoplasms ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Ovarian Mass ◽  
Immunohistochemical Examination ◽  
Stromal Tumors ◽  
Sex Cord Stromal Tumors ◽  
Leydig Cell Tumors

Ovarian sex cord-stromal tumors arise from the stromal cells that surround and support the oocytes. Sertoli-Leydig cell tumors belong to this category of ovarian neoplasms. We present the case of a 38-year-old woman who was found to have a right ovarian mass. The mass was resected and diagnosed as Stage I Sertoli-Leydig cell tumor, retiform variant, following histopathologic and immunohistochemical examination. This case is unusual given the rarity of the retiform variant of Sertoli-Leydig cell tumor and the atypically older age of 38 years at presentation.

scholarly journals Testicular Leydig Cell Tumor with Metachronous Lesions: Outcomes after Metastasis Resection and Cryoablation

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Julio J. Geminiani ◽  
Stephen D. Marshall ◽  
Tammy S. Ho ◽  
Steven B. Brandes
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Leydig Cell ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Surgical Pathology ◽  
Radiographic Findings ◽  
Prepubertal Boys ◽  
Chemotherapeutic Treatment ◽  
Leydig Cell Tumors

Leydig cell tumors represent 3% of testicular masses and usually occur in prepubertal boys and men between 30 and 60 years of age. Leydig cell tumors are benign in children but can be malignant in 10% of adults. This case report describes a 41-year-old patient who was diagnosed with a Leydig cell tumor that originated in his right testicle that subsequently metastasized to his liver, lungs, and retroperitoneum. We discuss the patient’s presentation and review the radiographic findings, surgical treatment, surgical pathology, chemotherapeutic treatment, and published literature on this rare pathology.

Metastatic Leydig Cell Tumor With Sarcomatoid Differentiation

1999 ◽  
Vol 123 (11) ◽  
pp. 1104-1107 ◽  
Author(s):  
H. Evin Gulbahce ◽  
Arthur T. Lindeland ◽  
William Engel ◽  
Tamera J. Lillemoe
Keyword(s):  
Leydig Cell ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Fat Tissue ◽  
The Right ◽  
Initial Metastasis ◽  
Leydig Cell Tumors ◽  
Perirenal Fat ◽  
Biphasic Tumor ◽  
Sarcomatoid Differentiation

Abstract Leydig cell tumors of the testis are uncommon. Only about 10% of cases have a malignant course. It has been stated that the only definite criterion for malignancy is presence of metastasis. We present a 47-year-old patient with metastatic Leydig cell tumor 17 years after initial diagnosis, to our knowledge the longest reported interval between diagnosis and the development of metastasis. The primary tumor did not exhibit convincing features of malignancy. The initial metastasis in the right perirenal fat tissue showed a biphasic tumor with sarcomatoid differentiation not described previously in a metastatic Leydig cell tumor.

922 LONG-TERM FOLLOW UP USING TESTICULAR SPARING SURGERY FOR LEYDIG CELL TUMOR

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Giorgio Bozzini ◽  
Stefano Picozzi ◽  
Franco Gadda ◽  
Renzo Colombo ◽  
Ottavio De Cobelli ◽  
...  
Keyword(s):  
Leydig Cell ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Long Term Follow Up

scholarly journals Marked hyperandrogenicity in a 60-year-old woman

2017 ◽  
Vol 2017 ◽  
Author(s):  
Khaled Aljenaee ◽  
Sulaiman Ali ◽  
Seong Keat Cheah ◽  
Owen MacEneaney ◽  
Niall Mulligan ◽  
...  
Keyword(s):  
Leydig Cell ◽  
Testosterone Level ◽  
Histopathological Examination ◽  
Incidental Finding ◽  
Serum Testosterone ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Serum Testosterone Level ◽  
List Type ◽  
Dheas Level

Markedly elevated androgen levels can lead to clinical virilization in females. Clinical features of virilization in a female patient, in association with biochemical hyperandrogenism, should prompt a search for an androgen-producing tumor, especially of ovarian or adrenal origin. We herein report the case of a 60-year-old woman of Pakistani origin who presented with the incidental finding of male pattern baldness and hirsutism. Her serum testosterone level was markedly elevated at 21 nmol/L (normal range: 0.4–1.7 nmol/L), while her DHEAS level was normal, indicating a likely ovarian source of her elevated testosterone. Subsequently, a CT abdomen-pelvis was performed, which revealed a bulky right ovary, confirmed on MRI of the pelvis as an enlarged right ovary, measuring 2.9 × 2.2 cm transaxially. A laparoscopic bilateral salpingo-oophorectomy was performed, and histopathological examination and immunohistochemistry confirmed the diagnosis of a Leydig cell tumor, a rare tumor accounting for 0.1% of ovarian tumors. Surgical resection led to normalization of testosterone levels. Learning points: Hirsutism in postmenopausal women should trigger suspicion of androgen-secreting tumor Extremely elevated testosterone level plus normal DHEAS level point toward ovarian source Leydig cell tumor is extremely rare cause of hyperandrogenicity

Long-Term Follow-Up Using Testicle-Sparing Surgery for Leydig Cell Tumor

2013 ◽  
Vol 11 (3) ◽  
pp. 321-324 ◽  
Author(s):  
Giorgio Bozzini ◽  
Stefano Picozzi ◽  
Franco Gadda ◽  
Renzo Colombo ◽  
Ottavio DeCobelli ◽  
...  
Keyword(s):  
Leydig Cell ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Long Term Follow Up

scholarly journals Synchronous Leydig Cell Tumor and Seminoma in the Ipsilateral Testis

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Ifeyinwa E. Obiorah ◽  
Alexandra Kyrillos ◽  
Metin Ozdemirli
Keyword(s):  
Leydig Cell ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Testicular Neoplasms ◽  
Therapeutic Management ◽  
Germinal Epithelium ◽  
Testicular Tumors ◽  
Concurrent Development ◽  
Disease Entities ◽  
Leydig Cell Tumors

Leydig cell tumor is a rare sex cord tumor that accounts for 1–3% of all testicular neoplasms. Seminomas are more common and occur in 30–40% of testicular tumors. Leydig cell tumors are derived from undifferentiated gonadal mesenchyme and the concurrent development of the tumor and a seminoma which are derived from germinal epithelium in an ipsilateral testis is extremely rare. Here we report a case of ipsilateral Leydig cell tumor and seminoma occurring in a 38-year-old man with a left testicular mass. The key to diagnosis is dependent on histopathology and immunohistochemistry. To our knowledge, this is the first diagnosis of the two disease entities in a unilateral testis using immunohistochemistry. Increased awareness of the entity is important in order to distinguish Leydig cell tumor and seminomas from other malignancies due to difference in therapeutic management.

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