Lymphocyte subsets' reference ranges in an age- and gender-balanced population of 100 healthy adults—A monocentric German study

2005 ◽  
Vol 116 (2) ◽  
pp. 192-197 ◽  
Author(s):  
K JENTSCHULLRICH ◽  
M KOENIGSMANN ◽  
M MOHREN ◽  
A FRANKE
2013 ◽  
Vol 83A (8) ◽  
pp. 739-744 ◽  
Author(s):  
Adhra Al-Mawali ◽  
Avinash Daniel Pinto ◽  
Raiya Al Busaidi ◽  
Ibrahim Al-Zakwani

2015 ◽  
Vol 90 (6) ◽  
pp. 538-542 ◽  
Author(s):  
Kejun Zhang ◽  
Feng Wang ◽  
Mingxu Zhang ◽  
Xinglu Cao ◽  
Shaojun Yang ◽  
...  

2012 ◽  
Vol 20 (4) ◽  
pp. 531-540 ◽  
Author(s):  
Eli-Anne Skaug ◽  
Stian Thoresen Aspenes ◽  
Line Oldervoll ◽  
Bjørn Mørkedal ◽  
Lars Vatten ◽  
...  

2019 ◽  
Vol 57 (8) ◽  
pp. 1242-1250 ◽  
Author(s):  
Felix Eckelt ◽  
Mandy Vogel ◽  
Mandy Geserick ◽  
Toralf Kirsten ◽  
Yoon Ju Bae ◽  
...  

Abstract Background There is only limited information on serum reference ranges of calcitonin (CT) in infants, children and adolescents. This gap hampers valid diagnostics in patients with multiple endocrine neoplasia type 2 (MEN 2) and planned prophylactic thyroidectomy. In addition, age-dependent reference ranges for CT are necessary to define a cure in medullary thyroid carcinoma (MTC). We asked whether the reference ranges for CT levels were age- and gender-dependent in the serum of a pediatric cohort. Methods A total of 6090 serum samples of 2639 subjects of the LIFE-Child cohort aged between 1 month and 17.9 years were analyzed by the CT electrochemiluminescence immunoassay (ECLIA). Reference intervals were estimated using the LMS method. For clinical validation the serum of 28 patients (61 samples) with MEN 2 and 106 patients (136 samples) with thyroid diseases were analyzed. Results CT levels showed a clear age- and gender-dependence with significantly higher values in boys (p<0.01). An accelerated decline of CT levels from newborn to children at the age of 4 and 5 years was observed for both sexes. A cure for MTC was demonstrated in 71% of MEN 2 patients after thyroidectomy, whereas 5 patients remained suspicious for micrometastasis or relapse. Only 1.5% of our patients with thyroid diseases revealed increased CT levels. Conclusions This is the largest study to establish novel pediatric reference ranges from the CT values of healthy subjects. It allows a precise laboratory monitoring of CT in pediatric patients with MEN 2. Thyroid diseases did not have a relevant influence on CT levels in our pediatric cohort.


2019 ◽  
Vol 25 (6) ◽  
pp. 526-533
Author(s):  
Munther S. Momani ◽  
Ayman A. Zayed ◽  
Hussam H. Alhawari ◽  
Enas Abu Salim ◽  
Ahmad M. Ghazali ◽  
...  

2019 ◽  
Vol 42 (2) ◽  
pp. 180-189 ◽  
Author(s):  
Javed Ahammad ◽  
Annamma Kurien ◽  
Shamee Shastry ◽  
Hitesh H. Shah ◽  
Dinesh Nayak ◽  
...  

2002 ◽  
Vol 35 ◽  
pp. 99-107 ◽  
Author(s):  
G. Colonna-Romano ◽  
A. Cossarizza ◽  
A. Aquino ◽  
G. Scialabba ◽  
M. Bulati ◽  
...  

2005 ◽  
Vol 57 (4) ◽  
pp. 285-292 ◽  
Author(s):  
Rohini Rocque ◽  
Doreen Bartlett ◽  
Janet Brown ◽  
S. Jayne Garland

Sign in / Sign up

Export Citation Format

Share Document