Chinese Bone Turnover Marker Study: Reference Ranges for C-Terminal Telopeptide of Type I Collagen and Procollagen I N-Terminal Peptide by Age and Gender

Objectives: In this study, we aimed to investigate the bone turnover marker levels according to bisphosphonate usage and radiotherapy (RT) in cancer patients with metastases in osteolytic pattern. Patients and methods: A total of 52 patients (13 males, 39 females; median age: 52 years; range, 37 to 78 years) treated with RT for osteolytic bone metastases between April 2005 and April 2006 were retrospectively analyzed. Bone-specific alkaline phosphatase (BAP), amino-terminal cross-linked telopeptide of type I collagen (NTX-I), amino-terminal propeptide of type I procollagen (PINP), osteocalcin (OC), deoxypyridinoline (DPD), pyridinoline (PYD), alkaline phosphatase (ALP), creatinine, calcium (Ca), phosphate (P), magnesium (Mg), and 24-h urine Ca levels were measured in blood and urine before the initiation of RT, six weeks and six months after RT. Results: A decrease in BAP, PINP, and creatinine levels was observed after RT (Week 6 p=0.006, Month 6 p=0.008). Sixteen patients who already used bisphosphonate before RT were excluded from statistical calculation. The remaining 36 patients who were treated with bisphosphonate after the first blood test were evaluated separately. In this group of patients, BAP, PINP, NTX, creatinine, and Ca levels significantly increased at six weeks after RT. The PINP and creatinine values significantly decreased at six months after RT. The variation between two different RT arms was assessed with repeated measures variance analysis. There was a statistically significant difference for NTX, OC, and creatinine levels between the first and second measurements. Conclusion: Radiotherapy is an effective method in the treatment of osteolytic bone metastases. Bone turnover markers can provide an objective evaluation on RT response and parallel to imaging modalities criteria for evaluation. Bisphosphonates may alter the levels of these indicators. However, in this study, there were no statistically significant differences between the levels of markers for two different RT schedules.

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The Potential Role of Curcumin in Patients with Monoclonal Gammopathy of Undefined Significance—Its Effect on Paraproteinemia and the Urinary N-Telopeptide of Type I Collagen Bone Turnover Marker

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-08-2217 ◽

2009 ◽

Vol 15 (18) ◽

pp. 5917-5922 ◽

Cited By ~ 59

Author(s):

Terry Golombick ◽

Terrence H. Diamond ◽

Vladimir Badmaev ◽

Arumugam Manoharan ◽

Rajeev Ramakrishna

Keyword(s):

Bone Turnover ◽

Monoclonal Gammopathy ◽

Potential Role ◽

Type I Collagen ◽

Bone Turnover Marker ◽

Type I

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Influence of Demographic Factors and Sport Type on Growth Hormone-Responsive Markers in Elite Athletes

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2006-0612 ◽

2006 ◽

Vol 91 (11) ◽

pp. 4424-4432 ◽

Cited By ~ 36

Author(s):

A. E. Nelson ◽

C. J. Howe ◽

T. V. Nguyen ◽

K.-C. Leung ◽

G. J. Trout ◽

...

Keyword(s):

Type I Collagen ◽

Elite Athletes ◽

Significant Negative Correlation ◽

Type I ◽

Cross Sectional ◽

Age And Gender ◽

Igf I ◽

And Gender ◽

Collagen Markers ◽

Igfbp 3

Abstract Context: GH-responsive markers of the IGF system and of collagen turnover hold promise as the basis of a GH doping test. Objective: The purpose of this study was to determine the influence of age, gender, body mass index (BMI), ethnicity, and sporting type on GH-responsive serum markers in a large cohort of elite athletes from different ethnic backgrounds. Design: The study was designed as a cross-sectional study. Participants: A total of 1103 elite athletes (699 males, 404 females), aged 22.2 ± 5.2 yr, from 12 countries and 10 major sporting categories participated in this study. Main Outcome Measures: Serum IGF-I, IGF binding protein-3 (IGFBP-3), acid labile subunit (ALS), and collagen markers [N-terminal propeptide of type I procollagen (PINP), C-terminal telopeptide of type I collagen (ICTP), N-terminal propeptide of type III procollagen (PIIINP)] were measured. Results: There was a significant negative correlation (r = −0.14 to −0.58, P < 0.0005) between age and each of the GH-responsive markers. Serum IGF-I, IGFBP-3, and ALS were all lower (P < 0.05), whereas the collagen markers PINP, ICTP, and PIIINP were higher (P < 0.05) in men than in women. Multiple regression analysis indicated that age, gender, BMI, and ethnicity accounted for 23–54% of total between-subject variability of the markers. Age and gender cumulatively accounted for 91% of the attributable variation of IGF-I and more than 80% for PINP, ICTP, and PIIINP. Gender exerted the greatest effect on ALS (48%), and BMI accounted for less than 12% attributable variation for all markers. The influence of ethnicity was greatest for IGFBP-3 and ALS; however, for the other markers, it accounted for less than 6% attributable variation. Analysis of 995 athletes indicated that sporting type contributed 5–19% of attributable variation. Conclusions: Age and gender were major determinants of variability of GH-responsive markers except for IGFBP-3 and ALS. Ethnicity is unlikely to confound the validity of a GH doping test based on IGF-I and these collagen markers.

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Use of bone turnover marker, pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP), in the assessment and monitoring of bone metastasis in prostate cancer

The Prostate ◽

10.1002/(sici)1097-0045(19990401)39:1<1::aid-pros1>3.0.co;2-x ◽

1999 ◽

Vol 39 (1) ◽

pp. 1-7 ◽

Cited By ~ 31

Author(s):

Hirofumi Koga ◽

Seiji Naito ◽

Shuji Koto ◽

Naotaka Sakamoto ◽

Michitaka Nakashima ◽

...

Keyword(s):

Prostate Cancer ◽

Bone Metastasis ◽

Bone Turnover ◽

Type I Collagen ◽

Bone Turnover Marker ◽

Type I ◽

Assessment And Monitoring ◽

Carboxyterminal Telopeptide

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Role of biochemical markers in the prediction of osteopenia and osteoporosis in men and women of Sikkim, India

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20184910 ◽

2018 ◽

Vol 6 (12) ◽

pp. 4077

Author(s):

Deepa Soibam ◽

Amumacha T. Singh ◽

Parvati Nandy ◽

Ankur Baruah

Keyword(s):

Bone Mass ◽

Bone Turnover ◽

Type I Collagen ◽

Bone Structure ◽

Bone Turnover Marker ◽

Type I ◽

Men And Women ◽

Significant Difference ◽

Turnover Markers ◽

The Individual

Background: Osteoporosis being a silently progressing disease, the real challenge is to identify the individual at high risk of osteoporosis. Many bone turnover marker have been associated with bone loss even before occurrence of any changes in bone structure. Therefore, this study was aim to evaluate the predictive value of bone turnover marker by correlating with low bone density.Methods: This was a case control study conducted in Sikkim Manipal Institute of Medical Sciences, India. A total of 300 subjects (150 case and 150 control) both male and female between the age group of 35- 65 were enrolled. We measure one bone formation marker serum osteocalcin and two resorption marker urine hydroxyproline (OHP) and urine N- terminal telopeptides of type I collagen (NTX). Calcaneal QUS device (GE Lunar Achilles Express heel- densitometer) was used to determine the bone density.Results: A significant difference of the bone markers i.e. hydroxyproline, NTx and osteocalcin were observed between cases and control of men and women with P<0.001. These variables statistically significantly predicts bone density with F (3, 71) = 5,671, P= 0.002, R2= 0.193 and F (3, 71) = 5.292, P= 0.002, R2= 0.183 in women and men respectively.Conclusions: Study showed that bone turnover markers are able to predict low bone mass. Resorption markers NTx and OHP were the main predictor in men whereas OHP and formation marker Osteocalcin in women. Therefore, BTM measurement along with BMD can provide useful information about the changes in the bone mass which will help to predict the risk of osteoporosis.

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Effects of different vibration frequencies on muscle strength, bone turnover and walking endurance in chronic stroke

Scientific Reports ◽

10.1038/s41598-020-80526-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Zhenhui Yang ◽

Tiev Miller ◽

Zou Xiang ◽

Marco Y. C. Pang

Keyword(s):

Muscle Strength ◽

Bone Turnover ◽

Intervention Program ◽

Type I Collagen ◽

Chronic Stroke ◽

Medium Effect ◽

Whole Body ◽

Type I ◽

Leg Muscle ◽

Walking Endurance

AbstractThis randomized controlled trial aimed to evaluate the effects of different whole body vibration (WBV) frequencies on concentric and eccentric leg muscle strength, bone turnover and walking endurance after stroke. The study involved eighty-four individuals with chronic stroke (mean age = 59.7 years, SD = 6.5) with mild to moderate motor impairment (Fugl-Meyer Assessment lower limb motor score: mean = 24.0, SD = 3.5) randomly assigned to either a 20 Hz or 30 Hz WBV intervention program. Both programs involved 3 training sessions per week for 8 weeks. Isokinetic knee concentric and eccentric extension strength, serum level of cross-linked N-telopeptides of type I collagen (NTx), and walking endurance (6-min walk test; 6MWT) were assessed at baseline and post-intervention. An intention-to-treat analysis revealed a significant time effect for all muscle strength outcomes and NTx, but not for 6MWT. The time-by-group interaction was only significant for the paretic eccentric knee extensor work, with a medium effect size (0.44; 95% CI: 0.01, 0.87). Both WBV protocols were effective in improving leg muscle strength and reducing bone resorption. Comparatively greater improvement in paretic eccentric leg strength was observed for the 30 Hz protocol.

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Serum levels of bone formation and resorption markers in relation to vitamin D status in professional gymnastics and physically active men during upper and lower body high-intensity exercise

Journal of the International Society of Sports Nutrition ◽

10.1186/s12970-021-00430-8 ◽

2021 ◽

Vol 18 (1) ◽

Author(s):

Jan Mieszkowski ◽

Andrzej Kochanowicz ◽

Elżbieta Piskorska ◽

Bartłomiej Niespodziński ◽

Joanna Siódmiak ◽

...

Keyword(s):

Vitamin D ◽

Bone Formation ◽

Bone Turnover ◽

Bone Turnover Markers ◽

Type I Collagen ◽

Serum Levels ◽

Type I ◽

Vitamin D Metabolites ◽

Physically Active ◽

Turnover Markers

Abstract Purpose/introduction To compare serum levels of bone turnover markers in athletes and non-athletes, and to evaluate the relationship between serum levels of vitamin D metabolites and exercise-induced changes in biomarker levels. Methods Sixteen elite male artistic gymnasts (EG; 21.4 ± 0.8 years-old) and 16 physically active men (the control group, PAM; 20.9 ± 1.2 years-old) performed lower and upper body 30-s Wingate anaerobic tests (LBWT and UBWT, respectively). For biomarker analysis, blood samples were collected before, and 5 and 30 min after exercise. Samples for vitamin D levels were collected before exercise. N-terminal propeptide of type I collagen (PINP) was analysed as a marker of bone formation. C-terminal telopeptide of type I collagen (CTX) was analysed as a marker of bone resorption. Results UBWT fitness readings were better in the EG group than in the PAM group, with no difference in LBWT readings between the groups. UBWT mean power was 8.8% higher in subjects with 25(OH)D3 levels over 22.50 ng/ml and in those with 24,25(OH)2D3 levels over 1.27 ng/ml. Serum CTX levels increased after both tests in the PAM group, with no change in the EG group. PINP levels did not change in either group; however, in PAM subjects with 25(OH)D3 levels above the median, they were higher than those in EG subjects. Conclusion Vitamin D metabolites affect the anaerobic performance and bone turnover markers at rest and after exercise. Further, adaptation to physical activity modulates the effect of anaerobic exercise on bone metabolism markers.

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Diurnal Rhythms of Bone Turnover Markers in Three Ethnic Groups

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2016-1183 ◽

2016 ◽

Vol 101 (8) ◽

pp. 3222-3230 ◽

Cited By ~ 25

Author(s):

Jean Redmond ◽

Anthony J. Fulford ◽

Landing Jarjou ◽

Bo Zhou ◽

Ann Prentice ◽

...

Keyword(s):

Bone Turnover ◽

Bone Metabolism ◽

Ethnic Groups ◽

Bone Turnover Markers ◽

Type I Collagen ◽

Diurnal Rhythms ◽

Type I ◽

Dihydroxyvitamin D ◽

1,25 Dihydroxyvitamin D ◽

Turnover Markers

Context: Ethnic groups differ in fragility fracture risk and bone metabolism. Differences in diurnal rhythms (DRs) of bone turnover and PTH may play a role. Objective: We investigated the DRs of plasma bone turnover markers (BTMs), PTH, and 1,25(OH)2D in three groups with pronounced differences in bone metabolism and plasma PTH. Participants: Healthy Gambian, Chinese, and white British adults (ages 60–75 years; 30 per country). Interventions: Observational study with sample collection every 4 hours for 24 hours. Main Outcomes: Levels of plasma C-terminal telopeptide of type I collagen, procollagen type-1 N-propeptide, N-mid osteocalcin, bone alkaline phosphatase, PTH, and 1,25-dihydroxyvitamin D were measured. DRs were analyzed with random-effects Fourier regression and cross-correlation and regression analyses to assess associations between DRs and fasting and 24-hour means of BTMs and PTH. Results: Concentrations of BTMs, PTH, and 1,25-dihydroxyvitamin D were higher in Gambians compared to other groups (P < .05). The DRs were significant for all variables and groups (P < .03) and were unimodal, with a nocturnal peak and a daytime nadir for BTMs, whereas PTH had two peaks. The DRs of BTMs and PTH were significantly cross-correlated for all groups (P < .05). There was a significant positive association between C-terminal telopeptide of type I collagen and PTH in the British and Gambian groups (P = .03), but not the Chinese group. Conclusions: Despite ethnic differences in plasma BTMs and PTH, DRs were similar. This indicates that alteration of rhythmicity and loss of coupling of bone resorption and formation associated with an elevated PTH in other studies may not uniformly occur across different populations and needs to be considered in the interpretation of PTH as a risk factor of increased bone loss.

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