scholarly journals Calcitonin measurement in pediatrics: reference ranges are gender-dependent, validation in medullary thyroid cancer and thyroid diseases

2019 ◽  
Vol 57 (8) ◽  
pp. 1242-1250 ◽  
Author(s):  
Felix Eckelt ◽  
Mandy Vogel ◽  
Mandy Geserick ◽  
Toralf Kirsten ◽  
Yoon Ju Bae ◽  
...  
Keyword(s):  
Reference Intervals ◽  
Thyroid Diseases ◽  
Reference Ranges ◽  
Limited Information ◽  
Serum Samples ◽  
Age And Gender ◽  
Medullary Thyroid ◽  
Men 2 ◽  
And Gender ◽  
Gender Dependence

Abstract Background There is only limited information on serum reference ranges of calcitonin (CT) in infants, children and adolescents. This gap hampers valid diagnostics in patients with multiple endocrine neoplasia type 2 (MEN 2) and planned prophylactic thyroidectomy. In addition, age-dependent reference ranges for CT are necessary to define a cure in medullary thyroid carcinoma (MTC). We asked whether the reference ranges for CT levels were age- and gender-dependent in the serum of a pediatric cohort. Methods A total of 6090 serum samples of 2639 subjects of the LIFE-Child cohort aged between 1 month and 17.9 years were analyzed by the CT electrochemiluminescence immunoassay (ECLIA). Reference intervals were estimated using the LMS method. For clinical validation the serum of 28 patients (61 samples) with MEN 2 and 106 patients (136 samples) with thyroid diseases were analyzed. Results CT levels showed a clear age- and gender-dependence with significantly higher values in boys (p<0.01). An accelerated decline of CT levels from newborn to children at the age of 4 and 5 years was observed for both sexes. A cure for MTC was demonstrated in 71% of MEN 2 patients after thyroidectomy, whereas 5 patients remained suspicious for micrometastasis or relapse. Only 1.5% of our patients with thyroid diseases revealed increased CT levels. Conclusions This is the largest study to establish novel pediatric reference ranges from the CT values of healthy subjects. It allows a precise laboratory monitoring of CT in pediatric patients with MEN 2. Thyroid diseases did not have a relevant influence on CT levels in our pediatric cohort.

scholarly journals Reference intervals for serum lipids and prevalence of dyslipidaemia in 6–12-year-old children: The Health Oriented Pedagogical Project (HOPP)

2018 ◽  
Vol 46 (21_suppl) ◽  
pp. 21-27 ◽  
Author(s):  
Martin Frank Strand ◽  
Per Morten Fredriksen ◽  
Ole Petter Hjelle ◽  
Morten Lindberg
Keyword(s):  
Total Cholesterol ◽  
Serum Lipids ◽  
Venous Blood ◽  
Elevated Serum ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Reference Intervals ◽  
Age And Gender ◽  
Norwegian Population ◽  
And Gender

Aims: Elevated serum lipid concentrations in childhood are thought to be risk factors for the development of cardiovascular disease later in life. The present study aims to provide age- and gender-related reference intervals for total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, and non-HDL cholesterol in healthy school children. We also investigated the prevalence of dyslipidaemia using the published criteria for these biomarkers. Methods: Venous blood and anthropometric data were collected from 1340 children in the HOPP study, aged between 6 and 12 years. Age- and gender-related reference intervals (2.5th and 97.5th percentiles) were established according to the IFCC recommendations, using the software RefVal 4.10. Results: Gender differences were observed for total cholesterol and non-HDL cholesterol, but not for HDL cholesterol. Age differences were observed for total cholesterol. The reference intervals were in the range of 3.1–5.9 mmol/L for total cholesterol, 1.0–2.4 mmol/L for HDL cholesterol and 1.4–4.2 mmol/L for non-HDL cholesterol. Dyslipidaemia prevalence was as follows: increased TC 9.6%, decreased HDL 1.6%, and increased non-HDL 5.6%. Conclusions: Age- and gender-related reference intervals in a Norwegian population are similar to those reported in other countries. The prevalence of dyslipidaemia among Norwegian children is significant, emphasising the importance of appropriate reference intervals in clinical practice.

Area, Age and Gender Dependence of the Nucleoside System in the Brain: a Review of Current Literature

2011 ◽  
Vol 11 (8) ◽  
pp. 1012-1033 ◽  
Author(s):  
Zsolt Kovacs ◽  
Gabor Juhasz ◽  
Miklos Palkovits ◽  
Arpad Dobolyi ◽  
Katalin A. Kekesi
Keyword(s):  
Current Literature ◽  
Age And Gender ◽  
And Gender ◽  
Gender Dependence ◽  
The Brain

scholarly journals Age and gender dependence of human cardiac phosphorus metabolites determined by SLOOP31P MR spectroscopy

2006 ◽  
Vol 56 (4) ◽  
pp. 907-911 ◽  
Author(s):  
Herbert Köstler ◽  
Wilfried Landschütz ◽  
Sabrina Koeppe ◽  
Tobias Seyfarth ◽  
Claudia Lipke ◽  
...  
Keyword(s):  
Mr Spectroscopy ◽  
Age And Gender ◽  
And Gender ◽  
Phosphorus Metabolites ◽  
Gender Dependence

Age‐ and gender‐related reference ranges for thromboelastography from a healthy Indian population

2019 ◽  
Vol 42 (2) ◽  
pp. 180-189 ◽  
Author(s):  
Javed Ahammad ◽  
Annamma Kurien ◽  
Shamee Shastry ◽  
Hitesh H. Shah ◽  
Dinesh Nayak ◽  
...  
Keyword(s):  
Indian Population ◽  
Reference Ranges ◽  
Age And Gender ◽  
And Gender

Soft Tissue Thickness Variations of the Nose: A Radiological Study

2020 ◽  
Vol 40 (7) ◽  
pp. 711-718
Author(s):  
Melekber Çavuş Özkan ◽  
Fatma Yeşil ◽  
İnci Bayramiçli ◽  
Mehmet Bayramiçli
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Soft Tissue Coverage ◽  
Limited Information ◽  
Tissue Thickness ◽  
Level Of Evidence ◽  
Age And Gender ◽  
Soft Tissue Envelope ◽  
Soft Tissue Thickness ◽  
And Gender

Abstract Background Soft tissue thickness (STT) is a major factor affecting the outcome in rhinoplasty. However, limited information is found in the literature on the age- and gender-related variations of the nasal STT. Objectives The purpose of this study was to measure STT at various landmarks over the nasal framework and compare the age- and gender-related differences. Methods STT measurements were made at 11 landmarks in 325 patients by employing magnetic resonance imaging. Patients were divided into subgroups to compare the STT differences between female and male and between the age groups as young, middle age, and elderly. Results Soft tissue was thickest at the nasion and thinnest at the rhinion. The soft tissue coverage was significantly thicker in the male population at the supratip, tip, nasal bones, upper lateral cartilages, and alar lobules, whereas it is thicker in females at the rhinion. Average thickness of the soft tissues over the entire nasal framework increases with age except the rhinion. Conclusions The STT is variable over different parts of the osteocartilaginous framework. Gender and age influence the STT. The soft tissue is thicker at the distal half of the nose in male patients, and these areas become gradually thicker with age, whereas the soft tissue over the midvault becomes thinner. Increasing age presents a particular challenge to achieve predictable results in rhinoplasty, and an understanding of the soft tissue envelope allows for improved aesthetic outcome. Level of Evidence 2

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