Association of follicle-stimulating hormone and sex hormone binding globulin with the metabolic syndrome in postmenopausal women

2012 ◽  
Vol 45 (9) ◽  
pp. 703-706 ◽  
Author(s):  
Anna Stefanska ◽  
Grazyna Sypniewska ◽  
Irena Ponikowska ◽  
Malgorzata Cwiklinska-Jurkowska
Keyword(s):  
Metabolic Syndrome ◽  
Postmenopausal Women ◽  
Follicle Stimulating Hormone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
The Metabolic Syndrome ◽  
Stimulating Hormone

scholarly journals Low sex hormone–binding globulin is associated with the metabolic syndrome in postmenopausal women

Metabolism ◽  
2006 ◽  
Vol 55 (11) ◽  
pp. 1473-1480 ◽  
Author(s):  
Melissa E. Weinberg ◽  
JoAnn E. Manson ◽  
Julie E. Buring ◽  
Nancy R. Cook ◽  
Ellen W. Seely ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Postmenopausal Women ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
The Metabolic Syndrome

scholarly journals Testosterone and Sex Hormone-Binding Globulin Predict the Metabolic Syndrome and Diabetes in Middle-Aged Men

Diabetes Care ◽  
2004 ◽  
Vol 27 (5) ◽  
pp. 1036-1041 ◽  
Author(s):  
D. E. Laaksonen ◽  
L. Niskanen ◽  
K. Punnonen ◽  
K. Nyyssonen ◽  
T.-P. Tuomainen ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Middle Aged ◽  
The Metabolic Syndrome

scholarly journals Statistical Genomic Approach Identifies Association between FSHR Polymorphisms and Polycystic Ovary Morphology in Women with Polycystic Ovary Syndrome

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Tao Du ◽  
Yu Duan ◽  
Kaiwen Li ◽  
Xiaomiao Zhao ◽  
Renmin Ni ◽  
...  
Keyword(s):  
Polycystic Ovary ◽  
Follicle Stimulating Hormone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Nucleotide Polymorphisms ◽  
Hormone Binding ◽  
Functional Variants ◽  
Fshr Gene ◽  
Genomic Approach ◽  
Stimulating Hormone

Background.Single-nucleotide polymorphisms (SNPs) in the follicle stimulating hormone receptor (FSHR) gene are associated with PCOS. However, their relationship to the polycystic ovary (PCO) morphology remains unknown. This study aimed to investigate whether PCOS related SNPs in the FSHR gene are associated with PCO in women with PCOS.Methods. Patients were grouped into PCO (n=384) and non-PCO (n=63) groups. Genomic genotypes were profiled using Affymetrix human genome SNP chip 6. Two polymorphisms (rs2268361 and rs2349415) of FSHR were analyzed using a statistical approach.Results. Significant differences were found in the allele distributions of the GG genotype of rs2268361 between the PCO and non-PCO groups (27.6% GG, 53.4% GA, and 19.0% AA versus 33.3% GG, 36.5% GA, and 30.2% AA), while no significant differences were found in the allele distributions of the GG genotype of rs2349415. When rs2268361 was considered, there were statistically significant differences of serum follicle stimulating hormone, estradiol, and sex hormone binding globulin between genotypes in the PCO group. In case of the rs2349415 SNP, only serum sex hormone binding globulin was statistically different between genotypes in the PCO group.Conclusions. Functional variants in FSHR gene may contribute to PCO susceptibility in women with PCOS.

Effects of gonadotropin-releasing hormone on bioactivity of follicle-stimulating hormone (FSH) and microstructure of FSH, luteinizing hormone and sex hormone-binding globulin in a testosterone-based contraceptive trial: evaluation of responders and non-responders

1996 ◽  
Vol 135 (4) ◽  
pp. 433-439 ◽  
Author(s):  
Manuela Simoni ◽  
Jörg Peters ◽  
Hermann M Behre ◽  
Sabine Kliesch ◽  
Eckhard Leifke ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Concanavalin A ◽  
Follicle Stimulating Hormone ◽  
Gonadotropin Releasing Hormone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Molecular Heterogeneity ◽  
Hormone Binding ◽  
Releasing Hormone ◽  
Stimulating Hormone

Simoni M, Peters J, Behre HM, Kliesch S, Leifke E, Nieschlag E. Effects of gonadotropin-releasing hormone on bioactivity of follicle-stimulating hormone (FSH) and microstructure of FSH. luteinizing hormone and sex hormone-binding globulin in a testosterone-based contraceptive trial: evaluation of responders and non-responders. Eur J Endocrinol 1996;135:433–9. ISSN 0804–4643 Only a proportion of normal men participating in testosterone-based contraceptive trials develop azoospermia (responders). This study analyzed whether serum follicle-stimulating hormone (FSH), luteinizing hormone (LH) and sex hormone-binding globulin (SHBG) are qualitatively different between responders and non-responders. Determination of in vitro bioactive FSH after stimulation with gonadotropin-releasing hormone (GnRH) and analysis of molecular heterogeneity of serum FSH. LH and SHBG was carried out by chromatofocusing and concanavalin-A affinity chromatography in eight men who had participated in a previous contraceptive study with testosterone buciclate. Blood was withdrawn at 15-min intervals on two basal occasions and 30, 45 and 60 min after iv administration of GnRH (100 μg). Pools of sera were separated by chromatofocusing in the pH range 3–6 and by lectin chromatography on concanavalin A. Immunoreactive FSH, LH and SHBG were assayed in the eluates. Bioactive FSH was analyzed by the rat Sertoli cell bioassay. Serum bioactive FSH increased after GnRH stimulation, without significant differences between responders and non-responders. The chromatofocusing profiles of serum FSH showed a significant shift towards the less acidic region after GnRH. The isoform distribution was similar in responders and non-responders. No significant differences were found in the relative proportion of FSH, LH and SHBG retained by concanavalin A. It is concluded that the extent of suppression of sperm production by androgen administration cannot be foreseen either on the basis of the response of bioactive FSH to GnRH administration or from the glycosylation pattern of serum FSH, LH and SHBG. E Nieschlag, Institute of Reproductive Medicine of the University, Domagkstr. 11, D-48129 Münster, Germany

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