Metabolism, Excretion, and Pharmacokinetics of [14C]-Radiolabeled Aleglitazar: A Phase I, Nonrandomized, Open-Label, Single-Center, Single-Dose Study in Healthy Male Volunteers

2012 ◽  
Vol 34 (2) ◽  
pp. 420-429 ◽  
Author(s):  
Stefan Sturm ◽  
Michael Seiberling ◽  
Idelette Weick ◽  
Axel Paehler ◽  
Christoph Funk ◽  
...  
Keyword(s):  
Single Dose ◽  
Phase I ◽  
Single Center ◽  
Healthy Male ◽  
Open Label ◽  
Single Dose Study ◽  
Healthy Male Volunteers ◽  
Male Volunteers ◽  
Dose Study

Pharmacokinetic of Rhein in Healthy Male Volunteers Following Oral and Retention Enema Administration of Rhubarb Extract: A Single Dose Study

2005 ◽  
Vol 33 (06) ◽  
pp. 839-850 ◽  
Author(s):  
Wei Zhu ◽  
Xue-Mei Wang ◽  
Li Zhang ◽  
Xiao-Ye Li ◽  
Bao-Xiu Wang
Keyword(s):  
Single Dose ◽  
Oral Administration ◽  
Dosage Adjustment ◽  
Pharmacokinetic Parameters ◽  
Healthy Male ◽  
Single Dose Study ◽  
Retention Enema ◽  
Healthy Male Volunteers ◽  
Male Volunteers ◽  
Dose Study

Rhubarb is a common herb used in traditional Chinese medicine. However, few publications exist about its pharmacokinetic profiles in animals or healthy volunteers. Whether retention enema administration of rhubarb extract affects its pharmacokinetics as well as its tolerability is unknown. Therefore, we set out to compare the pharmacokinetic parameters of rhein administered by retention enemas with those of conventional oral dosing of rhubarb extract. Eight healthy male volunteers were enrolled in a prospective crossover study. All subjects received a single dose of rhubarb extract (50 mg·kg-1) on two separate occasions, once orally, once by a retention enema. Rhein plasma concentration was measured by HPLC. The C max , AUC 0-∞, AUMC were significantly higher in oral administration than those in retention enema administration ( p < 0.05), while V d of rhein after oral administration of rhubarb extract was significantly lower ( p < 0.05) than that after retention enema administration. However, no statistically significant differences between the two treatments were observed for any of the other pharmacokinetic parameters ( T max , t 1/2, MRT 0-∞, CL ). Dosage adjustment is advisable for retention enema administration of rhubarb extract in patients.

Pharmacokinetics and Safety of DS-8500a, an Antidiabetic Drug, in Japanese Subjects with Hepatic or Renal Impairment: A Single-Center, Open-Label, Single-Dose Study

2018 ◽  
Vol 35 (8) ◽  
pp. 1239-1250 ◽  
Author(s):  
Manabu Kato ◽  
Hitoshi Ishizuka ◽  
Takashi Taguchi ◽  
Kazuhito Shiosakai ◽  
Emi Kamiyama ◽  
...  
Keyword(s):  
Single Dose ◽  
Renal Impairment ◽  
Single Center ◽  
Antidiabetic Drug ◽  
Open Label ◽  
Single Dose Study ◽  
Dose Study ◽  
Japanese Subjects
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