scholarly journals ESCMID COVID-19 Living guidelines: drug treatment and clinical management

2021 ◽  
Author(s):  
Michele Bartoletti ◽  
Ozlem Azap ◽  
Aleksandra Barac ◽  
Linda Bussini ◽  
Onder Ergonul ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Clinical Management

Efficacy of clinical management vs. drug treatment in depression

1995 ◽  
Vol 37 (9) ◽  
pp. 611-612
Author(s):  
U.F. Malt ◽  
O.H. Robak ◽  
H-P. Madsbu ◽  
O. Bakke ◽  
M. Loeb ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Clinical Management

scholarly journals Comparative evaluation of the chemotherapeutic efficacies of two salts of diminazene aceturate in Trypanosoma brucei brucei infected dogs

2021 ◽  
Vol 18 (9) ◽  
pp. 1961-1967
Author(s):  
Ukamaka U. Eze ◽  
Ifeanyi G. Eke ◽  
Ikenna O. Ezeh ◽  
Terry A. Nzeakor ◽  
Callistus Owube ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Trypanosoma Brucei ◽  
Clinical Management ◽  
Parasite Clearance ◽  
Treated Group ◽  
Blood Stream ◽  
Post Treatment ◽  
Trypanosoma Brucei Brucei ◽  
Diminazene Aceturate ◽  
Experimental Canine

Purpose: To compare the anti-trypanosomal efficacies of 4,4-(diazoaminedibenzamidinetrihydrate) diacetate (4,4-DDBT) and 4,4-(diazoamino) benzamidine (4,4-DB) in experimental canine trypanosomosis. Methods: The efficacies of 4,4-DDBT and 4,4-DB were evaluated in 4 groups of dogs (n = 3) designated A-D. Group A was normal control without infection or drug treatment, group B did not receive any drug treatment but was infected with Trypanosoma brucei brucei, while groups C and D were infected with T. b. brucei and treated with 4,4-DDBT(3.5 mg/kg) and 4,4-DB (3.5 mg/kg), respectively. Results: The incubation period of the infection was 6 - 9 days post-infection. Treatment of the dogs with 4,4-DDBT led to zero parasitaemia 48 h post-treatment, while there was only a decrease in parasitemia to log 6 in 4,4-DB-treated dogs. Resurgence of parasite into the blood stream occurred in 4,4-DDBTtreated dogs 6 days after initial parasite clearance. Blood analyses post-treatment revealed elevated leucocytes and lymphocytes in 4,4-DB-treated dogs (p < 0.05). Packed cell volume was also observed to be higher in 4,4-DDBT-treated group when compared to 4,4-DB group (p < 0.05). Conclusion: These findings suggest that 4,4-DDBT is more efficacious in the clinical management of canine trypanosomosis caused by T. b. brucei. However, it does not prevent relapse of infection. Based on these findings, therefore, 4,4-DDBT should be the diminazene salt of choice when indicated in the clinical management of T. b. brucei infection in dogs.

Myasthenia Gravis

PEDIATRICS ◽  
1959 ◽  
Vol 24 (1) ◽  
pp. 164-165
Author(s):  
PATRICK F. BRAY
Keyword(s):  
New York ◽  
New York City ◽  
Drug Treatment ◽  
Myasthenia Gravis ◽  
York City ◽  
Clinical Management ◽  
Personal Experience ◽  
General Management ◽  
Precise Knowledge ◽  
The Subject

The need for a monograph on the subject of myasthenia gravis has been considerable because the clinical management of this multifaceted problem requires precise knowledge of therapeutic details together with a reasonable knowledge of the disturbed neuromuscular physiology. The author has laid emphasis in this text on the practical clinical matters of diagnosis, drug treatment and general management. His personal experience with 350 cases of myasthenia gravis seen at Mt. Sinai Hospital in New York City provides the groundwork for his discussion. The incidence of this condition is not well known, but the author and other workers feel that for every known patient with myasthenia, one or two patients with the disease remain undetected.

Assessing the Use of Age-Equivalent Scores in Clinical Management

1992 ◽  
Vol 23 (1) ◽  
pp. 6-8 ◽  
Author(s):  
Carol W. Lawrence
Keyword(s):  
Case Management ◽  
Clinical Management ◽  
Management Decisions ◽  
Language Deficits

Speech-language evaluation reports from many institutions present age-equivalent scores as the evidence for speech-language deficits. Yet, the value and interpretation of this measurement criterion requires clinical scrutiny. This article reviews the concept and derivation of age-equivalent scores and presents arguments against their use in case management decisions.

Structural Aspects of Phonological Development

1988 ◽  
Vol 19 (1) ◽  
pp. 5-16 ◽  
Author(s):  
Karen E. Pollock ◽  
Richard G. Schwartz
Keyword(s):  
Clinical Management ◽  
Structural Complexity ◽  
Strong Preference ◽  
Phonological Development ◽  
Structural Position ◽  
Phonological Disorders ◽  
Syllabic Structure ◽  
The Relationship ◽  
Structural Aspects ◽  
Target Words

The relationship between syllabic structure and segmental development was examined longitudinally in a child with a severe phonological disorder. Six speech samples were collected over a 4-year period (3:5 to 7:3). Analyses revealed gradual increases in the complexity and diversity of the syllable structures produced, and positional preferences for sounds within these forms. With a strong preference for [d] and [n] at the beginning of syllables, other consonants appeared first at the end of syllables. Implications for clinical management of phonological disorders include the need to consider both structural position and structural complexity in assessing segmental skills and in choosing target words for intervention.

Sign in / Sign up

Export Citation Format

Share Document