Summation of semantic priming and complex sentence comprehension in Parkinson's disease

2005 ◽  
Vol 25 (1) ◽  
pp. 78-89 ◽  
Author(s):  
Anthony J. Angwin ◽  
Helen J. Chenery ◽  
David A. Copland ◽  
Bruce E. Murdoch ◽  
Peter A. Silburn
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Semantic Priming ◽  
Sentence Comprehension ◽  
Complex Sentence

Cognitive and Physiological Substrates of Impaired Sentence Processing in Parkinson's Disease

1993 ◽  
Vol 5 (4) ◽  
pp. 480-498 ◽  
Author(s):  
Murray Grossman ◽  
Susan Carvell ◽  
Stephen Gollomp ◽  
Matthew B. Stern ◽  
Martin Reivich ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Frontal Cortex ◽  
Sentence Processing ◽  
Sentence Comprehension ◽  
Short Term Memory ◽  
Brain Regions ◽  
Positron Emission ◽  
Left Caudate ◽  
Regional Cerebral Glucose Metabolism

Sentence comprehension is a complex process involving at least a grammatical processor and a procedural component that supports language computations. One type of cerebral architecture that may underlie sentence processing is a network of distributed brain regions. We report two experiments designed to evaluate the cognitive and physiological substrate of sentence processing diaculties in nondemented patients with Parkinson's disease (PD). In the first experiment, patients answered simple questions about sentences that varied in their computational demands. Group and individual patient analyses indicated that PD patients are significantly compromised on this task, and that their difficulties become more prominent as the computational demands of the sentences increase. We manipulated the set of sentences to stress performance aspects of sentence processing. PD patients were compromised in their ability to detect errors in the presence and nature of a sentence's grammatical morphemes, suggesting a deficit in selective attention, but their ability to answer questions about a sentence was not afFected by short-term memory factors. In the second experiment, positron emission tomography was used to correlate this pattern of sentence comprehension impairment with regional cerebral glucose metabolism (rCMRgl) obtained at rest in a representative subset of these PD patients. Grammatical comprehension and attention in sentence processing correlated significantly with mesial frontal rCMRgl. Regression analyses confirmed the central role of left mesial frontal cortex, and identified a subsidiary role for left caudate in overall sentence comprehension, for left dorsolateral frontal cortex in grammatical processing, and for bilateral dorsolateral frontal cortex in attending to the presence of grammatical features. We conclude that compromised mesial frontal functioning underlies in part the sentence processing deficit of these patients, and these data illustrate one method for mapping portions of a sentence processing mechanism onto a distributed cerebral architecture.

scholarly journals The basal ganglia and semantic engagement: Potential insights from semantic priming in individuals with subcortical vascular lesions, Parkinson's disease, and cortical lesions

2003 ◽  
Vol 9 (7) ◽  
pp. 1041-1052 ◽  
Author(s):  
DAVID COPLAND
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Semantic Priming ◽  
Semantic Processing ◽  
Semantic Network ◽  
Vascular Lesions ◽  
Cortical Lesions ◽  
The Impact ◽  
Prime Target

The impact of basal ganglia dysfunction on semantic processing was investigated by comparing the performance of individuals with nonthalamic subcortical (NS) vascular lesions, Parkinson's disease (PD), cortical lesions, and matched controls on a semantic priming task. Unequibiased lexical ambiguity primes were used in auditory prime-target pairs comprising 4 critical conditions; dominant related (e.g., bank–money), subordinate related (e.g., bank–river), dominant unrelated (e.g., foot–money) and subordinate unrelated (e.g., bat–river). Participants made speeded lexical decisions (word/nonword) on targets using a go–no-go response. When a short prime–target interstimulus interval (ISI) of 200 ms was employed, all groups demonstrated priming for dominant and subordinate conditions, indicating nonselective meaning facilitation and intact automatic lexical processing. Differences emerged at the long ISI (1250 ms), where control and cortical lesion participants evidenced selective facilitation of the dominant meaning, whereas NS and PD groups demonstrated a protracted period of nonselective meaning facilitation. This finding suggests a circumscribed deficit in the selective attentional engagement of the semantic network on the basis of meaning frequency, possibly implicating a disturbance of frontal–subcortical systems influencing inhibitory semantic mechanisms. (JINS, 2003, 9, 1041–1052.)

Sentence comprehension in Parkinson's disease: The role of attention and memory

1992 ◽  
Vol 42 (4) ◽  
pp. 347-384 ◽  
Author(s):  
Murray Grossman ◽  
Susan Carvell ◽  
Matthew B. Stern ◽  
Stephen Gollomp ◽  
Howard I. Hurtig
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sentence Comprehension ◽  
Attention And Memory

scholarly journals Sentence Comprehension and Its Association with Executive Functions in Patients with Parkinson's Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-15 ◽  
Author(s):  
Katrien S. F. Colman ◽  
Janneke Koerts ◽  
Laurie A. Stowe ◽  
Klaus L. Leenders ◽  
Roelien Bastiaanse
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Executive Functions ◽  
Sentence Comprehension ◽  
Sentence Length ◽  
Control Subjects ◽  
Set Switching ◽  
Moderate Disease ◽  
Healthy Control ◽  
Structure Complexity

Coexistent impairments in executive functions and language comprehension in patients with Parkinson's disease (PD) have been repeatedly observed. In this study, the aim was to provide insights into the interaction between linguistic representation and processing and executive functioning. Therefore, sentence comprehension and executive functions were assessed in 28 Dutch-speaking PD patients and 28 healthy control subjects. Three aspects of the sentence materials were varied: (1) phrase structure complexity, (2) sentence length, and (3) picture congruence. PD patients with mild-to-moderate disease severity showed decreased sentence comprehension compared to healthy control subjects. The difficulties encountered by PD patients were not limited to one aspect of the sentence materials. The same pattern of results was present in healthy control subjects. Deficits in set-switching were specifically associated with the comprehension of passive sentences. Generally, our study confirms that there does not appear to be a language faculty encapsulated from the influence of executive functions.

Basal ganglia dysfunction, working memory, and sentence comprehension in patients with Parkinson's disease

2001 ◽  
Vol 39 (9) ◽  
pp. 962-971 ◽  
Author(s):  
Reid L Skeel ◽  
Bruce Crosson ◽  
Stephen E Nadeau ◽  
James Algina ◽  
Russell M Bauer ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Working Memory ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Sentence Comprehension

Nicotine effects on general semantic priming in Parkinson's disease.

2011 ◽  
Vol 19 (3) ◽  
pp. 215-223 ◽  
Author(s):  
Anna D. Holmes ◽  
David A. Copland ◽  
Peter A. Silburn ◽  
Helen J. Chenery
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Semantic Priming ◽  
General Semantic

scholarly journals Neural signatures of predictive language processing in parkinson’s disease with and without mild cognitive impairment

2020 ◽  
Author(s):  
Patricia León-Cabrera ◽  
Javier Pagonabarraga ◽  
Joaquín Morís ◽  
Saúl Martínez-Horta ◽  
Juan Marín-Lahoz ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Language Processing ◽  
Semantic Processing ◽  
Sentence Comprehension ◽  
Event Related Potentials ◽  
Final Word ◽  
Related Potentials

ABSTRACTCognitive deficits are common in Parkinson’s disease (PD), with some PD patients meeting criteria for mild cognitive impairment (MCI). An unaddressed question is whether linguistic prediction is preserved in PD. This ability is nowadays deemed crucial in achieving fast and efficient comprehension, and it may be negatively impacted by cognitive deterioration. To fill this gap of knowledge, we used event-related potentials (ERPs) to evaluate mechanisms of linguistic prediction in a sample of PD patients (on dopamine compensation) with and without MCI. To this end, participants read sentence contexts that were predictive or not about a sentence-final word. The final word appeared after 1 second, matching or mismatching the prediction. The introduction of the interval allowed to capture neural responses both before and after sentence-final words, reflecting semantic anticipation and processing. PD patients with normal cognition (N = 58) showed ERP responses comparable to those of matched controls. Specifically, in predictive contexts, a slow negative potential developed prior to sentence-final words, reflecting semantic anticipation. Later, expected words elicited reduced N400 responses (compared to unexpected words), indicating facilitated semantic processing. Besides, PD patients with MCI (N = 20) showed a prolongation of the N400 congruency effect (compared to matched PD patients without MCI), indicating that further cognitive decline impacts semantic processing. Finally, lower verbal fluency scores correlated with prolonged N400 congruency effects and with reduced pre-word differences in all PD patients (N = 78). This relevantly points to a role of deficits in temporal-dependent mechanisms in PD, besides prototypical frontal dysfunction, in altered semantic anticipation and semantic processing during sentence comprehension.

scholarly journals The Influence of Dopamine on Automatic and Controlled Semantic Activation in Parkinson's Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Wendy L. Arnott ◽  
David A. Copland ◽  
Helen J. Chenery ◽  
Bruce E. Murdoch ◽  
Peter A. Silburn ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Semantic Priming ◽  
Semantic Processing ◽  
Healthy Adult ◽  
Healthy Adults ◽  
Semantic Activation ◽  
Dopamine Depletion ◽  
Adult Participants ◽  
The Impact

Two semantic priming tasks, designed to isolate automatic and controlled semantic activation, were utilized to investigate the impact of dopamine depletion on semantic processing in Parkinson's disease (PD). Seven people with PD (tested whilst on and off levodopa medication) and seven healthy adults participated in the study. The healthy adult participants demonstrated intact automatic and controlled semantic activation. Aberrant controlled semantic activation was observed in the PD group on levodopa; however, automatic semantic activation was still evident. In contrast, automatic semantic activation was not evident in the PD group off levodopa. These results further clarify the impact of PD on semantic processing, demonstrating that dopamine depletion can cause disturbances in both automatic and controlled semantic activation.

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