Recent trends in synthetic enzymatic cascades promoted by alcohol dehydrogenases

Current Opinion in Green and Sustainable Chemistry ◽

10.1016/j.cogsc.2021.100548 ◽

2021 ◽

Vol 32 ◽

pp. 100548

Author(s):

Gonzalo de Gonzalo ◽

Caroline E. Paul

Keyword(s):

Alcohol Dehydrogenases ◽

Enzymatic Cascades ◽

Recent Trends

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Enzymatic cascades for the stereo-complementary epimerisation of in situ generated epoxy alcohols

Organic & Biomolecular Chemistry ◽

10.1039/c7ob00015d ◽

2017 ◽

Vol 15 (12) ◽

pp. 2562-2568 ◽

Cited By ~ 15

Author(s):

Yu-Chang Liu ◽

Chao Guo ◽

Yan Liu ◽

Hai-Bo Wang ◽

Zhong-Liu Wu

Keyword(s):

Alcohol Dehydrogenases ◽

Whole Cell ◽

Styrene Monooxygenase ◽

Enzymatic Cascades ◽

Epoxy Alcohols

Styrene monooxygenase and each of the two sets of alcohol dehydrogenases work in a tandem concurrent manner for the production of chiral epoxy alcohols using whole-cell catalysts.

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High time resolution enzyme cytochemistry of rod outer segment

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100161953 ◽

1990 ◽

Vol 48 (3) ◽

pp. 878-879

Author(s):

Takuma Saito ◽

Toshihiro Takizawa

Keyword(s):

Enzyme Activities ◽

Outer Segment ◽

Rapid Change ◽

High Time Resolution ◽

Visual Cell ◽

Enzyme Cytochemistry ◽

Activation Effect ◽

Rod Outer Segment ◽

Enzymatic Cascades ◽

Rapid Drop

Cells and tissues live on a number of dynamic metabolic pathways, which are made up of sequential enzymatic cascades.Recent biochemical and physiological studies of vision research showed the importance of cGMP metabolism in the rod outer segment of visual cell, indicat ing that the photon activated rhodopsin exerts activation effect on the GTP binding protein, transducin, and this act ivated transducin further activates phosphodiesterase (PDEase) to result in a rapid drop in cGMP concentration in the cytoplasm of rod outer segment. This rapid drop of cGMP concentration exerts to close the ion channel on the plasma membrane and to stop of inward current brings hyperpolarization and evokes an action potential.These sequential change of enzyme activities, known as cGMP cascade, proceeds quite rapidly within msec order. Such a rapid change of enzyme activities, such as PDEase in rod outer segment, was not a matter of conventional histochemical invest igations.

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