Micro-nano manufacturing of Ti6Al4V antibacterial surface

The creation of nanostructures with precise chemistries on material surfaces is of importance in a wide variety of areas such as lithography, superhydrophobicity, and cell adhesion. We describe a platform for surface functionalization that involves the fabrication of cylindrical micellar brushes on a silicon wafer through seeded growth of crystallizable block copolymers at the termini of immobilized, surface-confined crystallite seeds. The density, length, and coronal chemistry of the micellar brushes can be precisely tuned, and post-growth decoration with nanoparticles enables applications in catalysis and antibacterial surface modification. The micellar brushes can also be grown on ultrathin two-dimensional materials such as graphene oxide nanosheets and further assembled into a membrane for the separation of oil-in-water emulsions and gold nanoparticles.

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pH responsive zwitterionic-to-cationic transition for safe self-defensive antibacterial application

Journal of Materials Chemistry B ◽

10.1039/d0tb01717e ◽

2020 ◽

Vol 8 (38) ◽

pp. 8908-8913

Author(s):

Jing Zhang ◽

Lei Liu ◽

Lu Wang ◽

Wenhe Zhu ◽

Huiyan Wang

Keyword(s):

Acid Production ◽

Bacterial Metabolism ◽

Ph Responsive ◽

Antibacterial Surface

UV-induced grafting is used to construct an amphiphilic antibacterial surface that can transform from antifouling to sterilization under the conditions of bacterial metabolism and acid production.

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Antibacterial surface modification of titanium implants in orthopaedics

Journal of Tissue Engineering ◽

10.1177/2041731418789838 ◽

2018 ◽

Vol 9 ◽

pp. 204173141878983 ◽

Cited By ~ 36

Author(s):

Wich Orapiriyakul ◽

Peter S Young ◽

Laila Damiati ◽

Penelope M Tsimbouri

Keyword(s):

Titanium Implants ◽

Implant Design ◽

Material Surface ◽

Bacterial Interaction ◽

Biomaterial Surface ◽

Antibacterial Surface ◽

Production Research ◽

The Cost ◽

Modification Of Titanium ◽

Review Current

The use of biomaterials in orthopaedics for joint replacement, fracture healing and bone regeneration is a rapidly expanding field. Infection of these biomaterials is a major healthcare burden, leading to significant morbidity and mortality. Furthermore, the cost to healthcare systems is increasing dramatically. With advances in implant design and production, research has predominately focussed on osseointegration; however, modification of implant material, surface topography and chemistry can also provide antibacterial activity. With the increasing burden of infection, it is vitally important that we consider the bacterial interaction with the biomaterial and the host when designing and manufacturing future implants. During this review, we will elucidate the interaction between patient, biomaterial surface and bacteria. We aim to review current and developing surface modifications with a view towards antibacterial orthopaedic implants for clinical applications.

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Surface Grafting Modification of Silk Fibroin by Atom Transfer Radical Polymerization

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.373-374.629 ◽

2008 ◽

Vol 373-374 ◽

pp. 629-632 ◽

Cited By ~ 7

Author(s):

Tie Ling Xing ◽

Hai Jiang Wang ◽

Zhan Xiong Li ◽

Guo Qiang Chen

Keyword(s):

Silk Fibroin ◽

Gel Permeation Chromatography ◽

Catalyst System ◽

Hydroxyl Groups ◽

Amino Groups ◽

Grafting Modification ◽

Antibacterial Surface ◽

Ft Ir ◽

Tertiary Amino

In this work, surface modification of silk fibroin was conducted by grafting dimethylaminoethyl methacrylate (DMAEMA) via ATRP to produce well controlled grafting silk. First, the amino groups and hydroxyl groups on the side chains of the silk fibroin reacted with 2-bromoisobutyryl bromide (BriB-Br) to obtain efficient initiator for ATRP. Subsequently, the functional silk fibroin was used as macroinitiator of DMAEMA in 1,2-dichlorobenzene in conjunction with CuBr/N,N,N',N",N" -pentamethyldiethylenetriamine (PMDETA) as a catalyst system. FT-IR characterization of the modified silk substrate showed a peak corresponding to DMAEMA indicating that the polymer had been formed on the silk surface. Following the polymerization, the tertiary amino groups on the grafted silk fibroin were quaternized to produce a large concentration of quaternary ammonium groups, which endowed the silk substrate with potential antibacterial surface. The graft chains were cleaved by acid hydrolysis and analyzed by gel permeation chromatography (GPC). The GPC results indicated that the graft layer were well-controlled.

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