Cationic nanocarrier of rhein based on hydrophobic ion pairing approach as intra-articular targeted regenerative therapy for osteoarthritis

2021 ◽  
pp. 112285
Author(s):  
Heba MK Ebada ◽  
Maha MA Nasra ◽  
Rasha A Nassra ◽  
Amany A Solaiman ◽  
Ossama Y Abdallah
Keyword(s):  
Ion Pairing ◽  
Regenerative Therapy ◽  
Hydrophobic Ion Pairing

Hydrophobic Ion Pairing of Peptide Antibiotics for Processing into Controlled Release Nanocarrier Formulations

2017 ◽  
Vol 15 (1) ◽  
pp. 216-225 ◽  
Author(s):  
Hoang D. Lu ◽  
Paradorn Rummaneethorn ◽  
Kurt D. Ristroph ◽  
Robert K. Prud’homme
Keyword(s):  
Controlled Release ◽  
Ion Pairing ◽  
Peptide Antibiotics ◽  
Hydrophobic Ion Pairing

Intra-Articular Injection of a Nanosuspension of Tetramethylpyrazine Dihydroxynaphthalenate for Stronger and Longer-Lasting Effects Against Osteoarthritis

2021 ◽  
Vol 17 (6) ◽  
pp. 1199-1207
Author(s):  
Hanmei Li ◽  
Hongyi Zhuo ◽  
Dan Yin ◽  
Wei Li ◽  
Yamei Zhang ◽  
...  
Keyword(s):  
Particle Size ◽  
Medicinal Plant ◽  
Treatment Effect ◽  
Retention Time ◽  
Therapeutic Efficacy ◽  
Ion Pairing ◽  
Systemic Toxicity ◽  
Joint Cavity ◽  
Hydrophobic Ion Pairing ◽  
Chinese Medicinal Plant

Tetramethylpyrazine (TMP), isolated from the rhizome of the traditional Chinese medicinal plant Chuanxiong (Ligusticum wallichii Franchat) shows therapeutic efficacy against osteoarthritis. After intra-articular injection, the retention time of TMP in the joint cavity is short, which limits its treatment effect. To avoid this problem, the present study explored the preparation of a TMP nanosuspension (TMP-NS) based on hydrophobic ion pairing. TMP-NS showed a particle size of approximately 588 nm and, after intra-articular injection in rats, it had longer retention in the articular cavity, higher TMP concentrations in joints, and greater anti-osteoarthritic efficacy than TMP solution. TMP-NS didn’t cause significant inflammation at the joint. These results suggest that TMP-NS may strengthen and prolong the therapeutic efficacy of TMP against osteoarthritis without systemic toxicity.

Novel skin penetrating berberine oleate complex capitalizing on hydrophobic ion pairing approach

2018 ◽  
Vol 549 (1-2) ◽  
pp. 76-86 ◽  
Author(s):  
Abrar S. Torky ◽  
May S. Freag ◽  
Maha M.A. Nasra ◽  
Ossama Y. Abdallah
Keyword(s):  
Ion Pairing ◽  
Hydrophobic Ion Pairing

Improved potency of cisplatin by hydrophobic ion pairing

2004 ◽  
Vol 54 (5) ◽  
pp. 441-448 ◽  
Author(s):  
Lixin Feng ◽  
Alexandra De Dille ◽  
Vicky J. Jameson ◽  
Leia Smith ◽  
William S. Dernell ◽  
...  
Keyword(s):  
Ion Pairing ◽  
Hydrophobic Ion Pairing

scholarly journals Hydrophobic ion pairing (HIP) of (poly)peptide drugs: Benefits and drawbacks of different preparation methods

2020 ◽  
Vol 151 ◽  
pp. 73-80 ◽  
Author(s):  
Richard Wibel ◽  
Julian David Friedl ◽  
Sergey Zaichik ◽  
Andreas Bernkop-Schnürch
Keyword(s):  
Ion Pairing ◽  
Peptide Drugs ◽  
Preparation Methods ◽  
Hydrophobic Ion Pairing

Insights into Hydrophobic Ion Pairing from Molecular Simulation and Experiment

ACS Nano ◽  
2020 ◽  
Vol 14 (5) ◽  
pp. 6097-6106 ◽  
Author(s):  
Daniel J. Kozuch ◽  
Kurt Ristroph ◽  
Robert K. Prud’homme ◽  
Pablo G. Debenedetti
Keyword(s):  
Molecular Simulation ◽  
Ion Pairing ◽  
Simulation And Experiment ◽  
Hydrophobic Ion Pairing
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