Intra-Articular Injection of a Nanosuspension of Tetramethylpyrazine Dihydroxynaphthalenate for Stronger and Longer-Lasting Effects Against Osteoarthritis

Tetramethylpyrazine (TMP), isolated from the rhizome of the traditional Chinese medicinal plant Chuanxiong (Ligusticum wallichii Franchat) shows therapeutic efficacy against osteoarthritis. After intra-articular injection, the retention time of TMP in the joint cavity is short, which limits its treatment effect. To avoid this problem, the present study explored the preparation of a TMP nanosuspension (TMP-NS) based on hydrophobic ion pairing. TMP-NS showed a particle size of approximately 588 nm and, after intra-articular injection in rats, it had longer retention in the articular cavity, higher TMP concentrations in joints, and greater anti-osteoarthritic efficacy than TMP solution. TMP-NS didn’t cause significant inflammation at the joint. These results suggest that TMP-NS may strengthen and prolong the therapeutic efficacy of TMP against osteoarthritis without systemic toxicity.

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In vitro antitumor effects of two novel compounds Y17 and Y18, isolated from a Chinese medicinal plant

Planta Medica ◽

10.1055/s-0035-1556281 ◽

2015 ◽

Vol 81 (11) ◽

Author(s):

N Almosnid ◽

Y Gao ◽

E Altman

Keyword(s):

Medicinal Plant ◽

Antitumor Effects ◽

Chinese Medicinal Plant

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Nigella Sativa: An immunity booster as pandemic treatment solution against SARS-CoV-2

Coronaviruses ◽

10.2174/2666796701999201209143642 ◽

2020 ◽

Vol 01 ◽

Author(s):

Afzal Hussain ◽

Ashfaq Hussain ◽

Chandan Kumar Verma

Keyword(s):

Medicinal Plant ◽

Therapeutic Efficacy ◽

Nigella Sativa ◽

Folk Medicine ◽

The World ◽

Immune Booster

: Nigella sativa (Family Ranunculaceae) is a common medicinal plant all across the world. It is quite popular in different traditional medicinal systems such as Unani, Ayurveda, Tibb, and Siddha. Oil and Seeds have a long tradition of folk medicine utilized in different medicinal systems and food. The seeds of N. Sativa have indeed been widely applied in the treatment of many diseases, ailments, and also the immune booster. Our goal primarily concentrated on the therapeutic efficacy of Nigella sativa in combating the COVID-19 pandemic.

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The Relationship Between Mixed-Liquor Particle Size and Solids Retention Time in the Activated Sludge Process

Water Environment Research ◽

10.2175/106143011x12928814445339 ◽

2011 ◽

Vol 83 (12) ◽

pp. 2178-2186 ◽

Cited By ~ 6

Author(s):

Licheng Chan ◽

Shao-Yuan Leu ◽

Diego Rosso ◽

Michael K. Stenstrom

Keyword(s):

Particle Size ◽

Activated Sludge ◽

Retention Time ◽

Activated Sludge Process ◽

Mixed Liquor ◽

Solids Retention Time ◽

Solids Retention ◽

The Relationship

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Effects of some Chinese medicinal plant extracts on five different fungi

Food Control ◽

10.1016/j.foodcont.2006.12.005 ◽

2007 ◽

Vol 18 (12) ◽

pp. 1547-1554 ◽

Cited By ~ 36

Author(s):

Sheng-Hsien Lee ◽

Ku-Shang Chang ◽

Min-Sheng Su ◽

Yung-Sheng Huang ◽

Hung-Der Jang

Keyword(s):

Medicinal Plant ◽

Plant Extracts ◽

Medicinal Plant Extracts ◽

Chinese Medicinal Plant

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Solubilisation of α-chymotrypsin by hydrophobic ion pairing in fluorous systems and supercritical carbon dioxide and demonstration of efficient enzyme recycling

Green Chemistry ◽

10.1039/b904761a ◽

2010 ◽

Vol 12 (1) ◽

pp. 54-59 ◽

Cited By ~ 7

Author(s):

Karima Benaissi ◽

Martyn Poliakoff ◽

Neil R. Thomas

Keyword(s):

Carbon Dioxide ◽

Supercritical Carbon Dioxide ◽

Ion Pairing ◽

Enzyme Recycling ◽

Hydrophobic Ion Pairing ◽

Supercritical Carbon

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Hydrophobic Ion Pairing of Peptide Antibiotics for Processing into Controlled Release Nanocarrier Formulations

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.7b00824 ◽

2017 ◽

Vol 15 (1) ◽

pp. 216-225 ◽

Cited By ~ 16

Author(s):

Hoang D. Lu ◽

Paradorn Rummaneethorn ◽

Kurt D. Ristroph ◽

Robert K. Prud’homme

Keyword(s):

Controlled Release ◽

Ion Pairing ◽

Peptide Antibiotics ◽

Hydrophobic Ion Pairing

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The complete chloroplast genome of a Chinese medicinal plant, Peristrophe japonica (Thunb.) Bremek. (Lamiales: Acanthaceae) from Nanjing, China

Mitochondrial DNA Part B ◽

10.1080/23802359.2021.1934157 ◽

2021 ◽

Vol 6 (7) ◽

pp. 1888-1889

Author(s):

Jingxin Chen ◽

Long Wang ◽

Yucheng Zhao ◽

Minjian Qin

Keyword(s):

Medicinal Plant ◽

Chloroplast Genome ◽

Complete Chloroplast Genome ◽

Chinese Medicinal Plant

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A comparison of particle breakdown during chewing by guanacos (Lama guanicoe) and sheep

Proceedings of the British Society of Animal Science ◽

10.1017/s1752756200597889 ◽

1998 ◽

Vol 1998 ◽

pp. 136-136

Author(s):

M.D. Fraser ◽

D.H. Baker

Keyword(s):

Particle Size ◽

Retention Time ◽

Microbial Fermentation ◽

Digestive Efficiency ◽

Particle Size Reduction ◽

Lama Guanicoe ◽

Factors Influencing ◽

Stomach Motility ◽

Pass Through ◽

Major Factors

To date, attempts to account for reported differences in digestive efficiency of camelids and ruminants have focused on factors such as stomach motility and the retention time of feed particles. The physical breakdown of forage into particles small enough to pass through the reticulo-omasal orifice is one of the major factors influencing the rate of passage of digesta from the reticulo-rumen in ruminants. Two of the main processes involved in particle size reduction are chewing (pre- and post-regurgitation) and microbial fermentation. While the characteristic vertical and horizontal jaw movement which occurs during mastication in the camelid is believed to allow for efficient use of the premolars and molars in cutting and grinding fibrous feeds, there have been no comparative studies to verify this, and to assess the contribution of chewing to differences in digestibility coefficients. The aim of this experiment was to directly compare particle breakdown during chewing by guanacos and sheep.

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