Uncertainty-based weight determination for surrogate optimization

2022 ◽  
Vol 237 ◽  
pp. 111850
Author(s):  
Doohyun Kim ◽  
Angela Violi
2020 ◽  
Author(s):  
Niranjan Raghunathan ◽  
Mikhail Bragin ◽  
Bing Yan ◽  
Peter Luh ◽  
Khosrow Moslehi ◽  
...  

Unit commitment (UC) is an important problem solved on a daily basis within a strict time limit. While hourly UC problems are currently considered, they may not be flexible enough with the fast-changing demand and the increased penetration of intermittent renewables. Sub-hourly UC is therefore recommended. This, however, will significantly increase problem complexity even under the deterministic setting, and current methods may not be able to obtain good solutions within the time limit. In this paper, deterministic sub-hourly UC is considered, with the innovative exploitation of soft constraints – constraints that do not need to be strictly satisfied, but with predetermined penalty coefficients for their violations. The key idea is the “surrogate optimization” concept that ensures multiplier convergence within “surrogate” Lagrangian relaxation as long as the “surrogate optimality condition” is satisfied without the need to optimally solve the “relaxed problem.” Consequently, subproblems can still be formed and optimized when soft constraints are not relaxed, leading to a drastically reduced number of multipliers and improved performance. To further enhance the method, a parallel version is developed. Testing results on the Polish system demonstrate the effectiveness and robustness of both the sequential and parallel versions at finding high-quality solutions within the time limit.


2019 ◽  
Vol 31 (4) ◽  
pp. 689-702 ◽  
Author(s):  
Juliane Müller ◽  
Marcus Day

We introduce the algorithm SHEBO (surrogate optimization of problems with hidden constraints and expensive black-box objectives), an efficient optimization algorithm that employs surrogate models to solve computationally expensive black-box simulation optimization problems that have hidden constraints. Hidden constraints are encountered when the objective function evaluation does not return a value for a parameter vector. These constraints are often encountered in optimization problems in which the objective function is computed by a black-box simulation code. SHEBO uses a combination of local and global search strategies together with an evaluability prediction function and a dynamically adjusted evaluability threshold to iteratively select new sample points. We compare the performance of our algorithm with that of the mesh-based algorithms mesh adaptive direct search (MADS, NOMAD [nonlinear optimization by mesh adaptive direct search] implementation) and implicit filtering and SNOBFIT (stable noisy optimization by branch and fit), which assigns artificial function values to points that violate the hidden constraints. Our numerical experiments for a large set of test problems with 2–30 dimensions and a 31-dimensional real-world application problem arising in combustion simulation show that SHEBO is an efficient solver that outperforms the other methods for many test problems.


2006 ◽  
Vol 21 (2) ◽  
pp. 568-578 ◽  
Author(s):  
P.B. Luh ◽  
W.E. Blankson ◽  
Y. Chen ◽  
J.H. Yan ◽  
G.A. Stern ◽  
...  

1986 ◽  
Vol 108 (3) ◽  
pp. 336-339 ◽  
Author(s):  
J. P. Karidis ◽  
S. R. Turns

An algorithm is presented for the efficient constrained or unconstrained minimization of computationally expensive objective functions. The method proceeds by creating and numerically optimizing a sequence of surrogate functions which are chosen to approximate the behavior of the unknown objective function in parameter-space. The Recursive Surrogate Optimization (RSO) technique is intended for design applications where the computational cost required to evaluate the objective function greatly exceeds both the cost of evaluating any domain constraints present and the cost associated with one iteration of a typical optimization routine. Efficient optimization is achieved by reducing the number of times that the objective function must be evaluated at the expense of additional complexity and computational cost associated with the optimization procedure itself. Comparisons of the RSO performance on eight widely used test problems to published performance data for other efficient techniques demonstrate the utility of the method.


2019 ◽  
Author(s):  
Sam Barker ◽  
Sarah V. Harding ◽  
David Gray ◽  
Mark I. Richards ◽  
Helen S. Atkins ◽  
...  

AbstractBurkholderia pseudomallei is a soil-dwelling organism present throughout the tropics, and is the causative agent of melioidosis, a disease that is believed to kill 89,000 people per year. It is naturally resistant to most currently available antibiotics. The most efficacious treatment for melioidosis requires at least two weeks of intravenous treatment with ceftazidime or meropenem. This places a large treatment burden on the predominantly middle income nations where the majority of disease occurs. We have established a high-throughput assay for compounds that could be used as a co-therapy to potentiate the effect of ceftazidime, using the related non-pathogenic bacterium Burkholderia thailandensis as a surrogate. Optimization of the assay gave a Z’ factor of 0.68. We screened a library of 61,250 compounds, and identified 29 compounds with a pIC50 (-log10(IC50)) greater than five. Detailed investigation allowed us to down select to six “best in class” compounds, which included the licensed drug chloroxine. Co-treatment of B. thailandensis with ceftazidime and chloroxine reduced culturable cell numbers by two orders of magnitude over 48 hours compared to treatment with ceftazidime alone. Hit expansion around chloroxine was performed using commercially available compounds. Minor modifications to the structure abolished activity, suggesting that chloroxine likely acts against a specific target. Finally, preliminary data also demonstrates the utility of chloroxine to act as a co-therapy to potentiate the effect of ceftazidime against B. pseudomallei. This approach successfully identified potential co-therapies for a recalcitrant Gram-negative bacterial species. Our assay could be used more widely to aid in chemotherapy against these bacteria.


2019 ◽  
Vol 34 ◽  
pp. 100546
Author(s):  
Yasushi Kawase ◽  
Kazuhisa Makino

2014 ◽  
Vol 16 (2) ◽  
pp. 441-481 ◽  
Author(s):  
Eka Suwartadi ◽  
Stein Krogstad ◽  
Bjarne Foss

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