scholarly journals Read-across of 90-day rodent repeated-dose toxicity: A case study for selected simple aryl alcohol alkyl carboxylic acid esters

2018 ◽  
Vol 7 ◽  
pp. 1-8 ◽  
Author(s):  
James W. Firman ◽  
Atish Patel ◽  
Mihir Date ◽  
Mark T.D. Cronin ◽  
Terry W. Schultz
Keyword(s):  
Carboxylic Acid ◽  
Repeated Dose ◽  
Repeated Dose Toxicity ◽  
Acid Esters

scholarly journals Read-across of 90-day rat oral repeated-dose toxicity: A case study for selected 2-alkyl-1-alkanols

2017 ◽  
Vol 2 ◽  
pp. 28-38 ◽  
Author(s):  
Terry W. Schultz ◽  
Katarzyna R. Przybylak ◽  
Andrea-Nicole Richarz ◽  
Claire L. Mellor ◽  
Steven P. Bradbury ◽  
...  
Keyword(s):  
Repeated Dose ◽  
Repeated Dose Toxicity

scholarly journals Read-across of 90-day rat oral repeated-dose toxicity: A case study for selected n -alkanols

2017 ◽  
Vol 2 ◽  
pp. 12-19 ◽  
Author(s):  
Terry W. Schultz ◽  
Katarzyna R. Przybylak ◽  
Andrea-Nicole Richarz ◽  
Claire L. Mellor ◽  
Sylvia E. Escher ◽  
...  
Keyword(s):  
Repeated Dose ◽  
Repeated Dose Toxicity

Applied chemical safety assessment case study for repeated dose toxicity integrating non-animal methods

2016 ◽  
Vol 258 ◽  
pp. S224-S225
Author(s):  
A. Richarz ◽  
F.Y. Bois ◽  
T. Exner ◽  
R. Judson ◽  
C. Mahony ◽  
...  
Keyword(s):  
Safety Assessment ◽  
Repeated Dose ◽  
Chemical Safety ◽  
Repeated Dose Toxicity

scholarly journals Read-across of 90-day rat oral repeated-dose toxicity: A case study for selected β-olefinic alcohols

2017 ◽  
Vol 1 ◽  
pp. 22-32 ◽  
Author(s):  
Katarzyna R. Przybylak ◽  
Terry W. Schultz ◽  
Andrea-N. Richarz ◽  
Claire L. Mellor ◽  
Sylvia E. Escher ◽  
...  
Keyword(s):  
Repeated Dose ◽  
Repeated Dose Toxicity

scholarly journals Read-across for rat oral gavage repeated-dose toxicity for short-chain mono-alkylphenols: A case study

2017 ◽  
Vol 2 ◽  
pp. 1-11 ◽  
Author(s):  
Claire L. Mellor ◽  
Terry W. Schultz ◽  
Katarzyna R. Przybylak ◽  
Andrea N. Richarz ◽  
Steven P. Bradbury ◽  
...  
Keyword(s):  
Short Chain ◽  
Repeated Dose ◽  
Oral Gavage ◽  
Repeated Dose Toxicity

Ketones from Nickel-Catalyzed Decarboxylative, Non-Symmetric Cross-Electrophile Coupling of Carboxylic Acid Esters

2019 ◽  
Author(s):  
Jiang Wang ◽  
Brian P. Cary ◽  
Peyton Beyer ◽  
Samuel H. Gellman ◽  
Daniel Weix
Keyword(s):  
Carboxylic Acid ◽  
Solid Support ◽  
Reaction Conditions ◽  
Decarboxylative Coupling ◽  
New Strategy ◽  
The Cross ◽  
Acyl Donors ◽  
Acid Esters

A new strategy for the synthesis of ketones is presented based upon the decarboxylative coupling of N-hydroxyphthalimide (NHP) esters with S-2-pyridyl thioesters. The reactions are selective for the cross-coupled product because NHP esters act as radical donors and the thioesters act as acyl donors. The reaction conditions are general and mild, with over 40 examples presented, including larger fragments and the 20-mer peptide Exendin(9-39) on solid support.

Oral Repeated-dose Toxicity Studies Especially in the Liver and Kidney of Rats Administered with Organic Germanium-fortified Yeasts

2006 ◽  
Vol 11 (2) ◽  
pp. 115-119 ◽  
Author(s):  
Sung-Hee Lee ◽  
Kyeong-Nam Oh ◽  
Sook-Nyung Rho ◽  
Bok-Hee Lee ◽  
Hyun-Joo Lee
Keyword(s):  
Repeated Dose ◽  
Toxicity Studies ◽  
Repeated Dose Toxicity ◽  
Liver And Kidney
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