scholarly journals Visual short-term memory binding deficit in familial Alzheimer's disease

Cortex ◽  
2016 ◽  
Vol 78 ◽  
pp. 150-164 ◽  
Author(s):  
Yuying Liang ◽  
Yoni Pertzov ◽  
Jennifer M. Nicholas ◽  
Susie M.D. Henley ◽  
Sebastian Crutch ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Short Term Memory ◽  
Short Term ◽  
Familial Alzheimer’S Disease ◽  
Term Memory ◽  
Visual Short Term Memory ◽  
Memory Binding ◽  
Familial Alzheimer's Disease

scholarly journals Visual short-term memory binding deficits in familial Alzheimer’s disease

Brain ◽  
2010 ◽  
Vol 133 (9) ◽  
pp. 2702-2713 ◽  
Author(s):  
Mario A. Parra ◽  
Sharon Abrahams ◽  
Robert H. Logie ◽  
Luis G. Méndez ◽  
Francisco Lopera ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Short Term Memory ◽  
Short Term ◽  
Familial Alzheimer’S Disease ◽  
Term Memory ◽  
Visual Short Term Memory ◽  
Memory Binding ◽  
Familial Alzheimer's Disease

scholarly journals Specific deficit of colour–colour short-term memory binding in sporadic and familial Alzheimer's disease

2011 ◽  
Vol 49 (7) ◽  
pp. 1943-1952 ◽  
Author(s):  
Mario A. Parra ◽  
Sergio Della Sala ◽  
Sharon Abrahams ◽  
Robert H. Logie ◽  
Luis Guillermo Méndez ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Short Term Memory ◽  
Short Term ◽  
Familial Alzheimer’S Disease ◽  
Term Memory ◽  
Memory Binding ◽  
Familial Alzheimer's Disease

scholarly journals Eye-tracking indices of impaired encoding of visual short-term memory in familial Alzheimer’s disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ivanna M. Pavisic ◽  
Yoni Pertzov ◽  
Jennifer M. Nicholas ◽  
Antoinette O’Connor ◽  
Kirsty Lu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Eye Movements ◽  
Short Term Memory ◽  
Fixation Time ◽  
Short Term ◽  
Familial Alzheimer’S Disease ◽  
Term Memory ◽  
Visual Short Term Memory ◽  
Familial Alzheimer's Disease

AbstractThe basis of visual short-term memory (VSTM) impairments in preclinical Alzheimer’s disease (AD) remains unclear. Research suggests that eye movements may serve as indirect surrogates to investigate VSTM. Yet, investigations in preclinical populations are lacking. Fifty-two individuals from a familial Alzheimer’s disease (FAD) cohort (9 symptomatic carriers, 17 presymptomatic carriers and 26 controls) completed the “Object-localisation” VSTM task while an eye-tracker recorded eye movements during the stimulus presentation. VSTM function and oculomotor performance were compared between groups and their association during encoding investigated. Compared to controls, symptomatic FAD carriers showed eye movement patterns suggestive of an ineffective encoding and presymptomatic FAD carriers within 6 years of their expected age at symptom onset, were more reliant on the stimuli fixation time to achieve accuracy in the localisation of the target. Consequently, for shorter fixation times on the stimuli, presymptomatic carriers were less accurate at localising the target than controls. By contrast, the only deficits detected on behavioural VSTM function was in symptomatic individuals. Our findings provide novel evidence that encoding processes may be vulnerable and weakened in presymptomatic FAD carriers, most prominently for spatial memory, suggesting a possible explanation for the subtle VSTM impairments observed in the preclinical stages of AD.

scholarly journals Visual short-term memory impairments in presymptomatic familial Alzheimer’s disease: A longitudinal observational study

2020 ◽  
Author(s):  
Ivanna M. Pavisic ◽  
Jennifer M. Nicholas ◽  
Yoni Pertzov ◽  
Antoinette O'Connor ◽  
Yuying Liang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Symptom Onset ◽  
Short Term Memory ◽  
Object Identification ◽  
Short Term ◽  
Familial Alzheimer’S Disease ◽  
Term Memory ◽  
Visual Short Term Memory ◽  
Familial Alzheimer's Disease

Abstract Visual short-term memory (VSTM) deficits including VSTM binding have been associated with Alzheimer’s disease (AD) from preclinical to dementia stages, cross-sectionally. Yet, longitudinal investigations are lacking. The objective of this study was to evaluate VSTM function longitudinally and in relation to expected symptom onset in a cohort of familial Alzheimer’s disease. Ninety-nine individuals (23 presymptomatic; 9 symptomatic and 67 controls) were included in an extension cross-sectional study and a sub-sample of 48 (23 presymptomatic carriers, 6 symptomatic and 19 controls), attending two to five visits with a median interval of 1.3 years, included in the longitudinal study. Participants completed the “What was where?” relational binding task (which measures memory for object identification, localisation and object-location binding under different conditions of memory load and delay), neuropsychology assessments and genetic testing. Compared to controls presymptomatic carriers within 8.5 years of estimated symptom onset, had a faster rate of decline in localisation performance in long-delay conditions (4 seconds) which preceded changes in traditional neuropsychology. This represents the first longitudinal VSTM investigation and shows that changes in memory resolution may be sensitive to tracking cognitive decline in preclinical AD.

scholarly journals Visual short-term memory binding deficits in Alzheimer's disease: a reply to Parra's commentary.

Cortex ◽  
2017 ◽  
Vol 88 ◽  
pp. 201-204 ◽  
Author(s):  
Yuying Liang ◽  
Yoni Pertzov ◽  
Jennifer M. Nicholas ◽  
Susie M.D. Henley ◽  
Sebastian Crutch ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Short Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Visual Short Term Memory ◽  
Memory Binding

scholarly journals Visual short-term memory binding in Alzheimer’s disease and depression

2010 ◽  
Vol 257 (7) ◽  
pp. 1160-1169 ◽  
Author(s):  
Mario A. Parra ◽  
Sharon Abrahams ◽  
Robert H. Logie ◽  
Sergio Della Sala
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Short Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Visual Short Term Memory ◽  
Memory Binding

scholarly journals Short-term memory binding deficits in Alzheimer's disease

Brain ◽  
2008 ◽  
Vol 132 (4) ◽  
pp. 1057-1066 ◽  
Author(s):  
M. A. Parra ◽  
S. Abrahams ◽  
K. Fabi ◽  
R. Logie ◽  
S. Luzzi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Short Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Memory Binding
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