The first invertebrate NFIL3 transcription factor with role in immune defense identified from the Hong Kong oyster, Crassostrea hongkongensis

2017 ◽  
Vol 76 ◽  
pp. 1-8 ◽  
Author(s):  
Jun Li ◽  
Yang Zhang ◽  
Yuehuan Zhang ◽  
Fan Mao ◽  
Zhiming Xiang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Hong Kong ◽  
Immune Defense ◽  
Crassostrea Hongkongensis

scholarly journals The first NFIL3/E4BP4 transcription factor with immune defense identified in the Hong Kong oyster, Crassostrea hongkongensis

2016 ◽  
Vol 53 ◽  
pp. 121 ◽  
Author(s):  
Jun Li ◽  
Ying Liu ◽  
Yuehuan Zhang ◽  
Yang Zhang ◽  
Fan Mao ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Hong Kong ◽  
Immune Defense ◽  
Crassostrea Hongkongensis

scholarly journals A thymosin beta-4 is involved in production of hemocytes and immune defense of Hong Kong oyster, Crassostrea hongkongensis

2016 ◽  
Vol 57 ◽  
pp. 1-9 ◽  
Author(s):  
Jun Li ◽  
Yuehuan Zhang ◽  
Ying Liu ◽  
Yang Zhang ◽  
Zhiming Xiang ◽  
...  
Keyword(s):  
Hong Kong ◽  
Immune Defense ◽  
Crassostrea Hongkongensis ◽  
Thymosin Beta 4

A novel molluscan Fos gene with immune defense function identified in the Hong Kong oyster, Crassostrea hongkongensis

2015 ◽  
Vol 51 (1) ◽  
pp. 194-201 ◽  
Author(s):  
Fufa Qu ◽  
Zhiming Xiang ◽  
Fuxuan Wang ◽  
Yang Zhang ◽  
Ying Tong ◽  
...  
Keyword(s):  
Hong Kong ◽  
Immune Defense ◽  
Crassostrea Hongkongensis ◽  
Defense Function

The identification of the first molluscan Akirin2 with immune defense function in the Hong Kong oyster Crassostrea hongkongensis

2014 ◽  
Vol 41 (2) ◽  
pp. 455-465 ◽  
Author(s):  
Fufa Qu ◽  
Zhiming Xiang ◽  
Yang Zhang ◽  
Jun Li ◽  
Yuehuan Zhang ◽  
...  
Keyword(s):  
Hong Kong ◽  
Immune Defense ◽  
Crassostrea Hongkongensis ◽  
Defense Function

scholarly journals The transcription factor ETS1 is an important regulator of human NK cell development and terminal differentiation

Blood ◽  
2020 ◽  
Author(s):  
Sylvie Taveirne ◽  
Sigrid Wahlen ◽  
Wouter Van Loocke ◽  
Laura Kiekens ◽  
Eva Persyn ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Cell Differentiation ◽  
Cell Biology ◽  
Nk Cell ◽  
Embryonic Stem ◽  
Terminal Differentiation ◽  
Cell Development ◽  
Immune Defense ◽  
Nk Cell Differentiation ◽  
Important Regulator

Natural killer (NK) cells are important in the immune defense against tumor cells and pathogens, and regulate other immune cells by cytokine secretion. Whereas murine NK cell biology has been extensively studied, knowledge about transcriptional circuitries controlling human NK cell development and maturation is limited. By generating ETS1-deficient human embryonic stem cells (hESC) and by expressing the dominant-negative ETS1 p27 isoform in cord blood (CB) hematopoietic progenitor cells (HPCs), we show that the transcription factor ETS1 is critically required for human NK cell differentiation. Genome-wide transcriptome analysis determined by RNA-sequencing combined with chromatin immunoprecipitation-sequencing (ChIP-seq) analysis reveals that human ETS1 directly induces expression of key transcription factors that control NK cell differentiation, i.e. E4BP4, TXNIP, TBET, GATA3, HOBIT and BLIMP1. In addition, ETS1 regulates expression of genes involved in apoptosis and NK cell activation. Our study provides important molecular insights into the role of ETS1 as an important regulator of human NK cell development and terminal differentiation.

Estrogen receptor regulates immune defense by suppressing NF-κB signaling in the Crassostrea hongkongensis

2020 ◽  
Vol 106 ◽  
pp. 796-803
Author(s):  
Dongbo Chen ◽  
Qiuhong Li ◽  
Hongmei Chen ◽  
Qingsong Huang ◽  
Manhong Zeng
Keyword(s):  
Estrogen Receptor ◽  
Immune Defense ◽  
Crassostrea Hongkongensis

Activator protein-1 (AP-1) and response to pathogen infection in the Hong Kong oyster (Crassostrea hongkongensis)

2014 ◽  
Vol 36 (1) ◽  
pp. 83-89 ◽  
Author(s):  
Zhiming Xiang ◽  
Fufa Qu ◽  
Jun Li ◽  
Lin Qi ◽  
Zhang Yang ◽  
...  
Keyword(s):  
Hong Kong ◽  
Activator Protein 1 ◽  
Pathogen Infection ◽  
Crassostrea Hongkongensis ◽  
Activator Protein
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