scholarly journals Brat Promotes Stem Cell Differentiation via Control of a Bistable Switch that Restricts BMP Signaling

2011 ◽  
Vol 20 (1) ◽  
pp. 72-83 ◽  
Author(s):  
Robin E. Harris ◽  
Michael Pargett ◽  
Catherine Sutcliffe ◽  
David Umulis ◽  
Hilary L. Ashe
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Bmp Signaling ◽  
Bistable Switch

scholarly journals Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation

2015 ◽  
Vol 35 (10) ◽  
pp. 1700-1711 ◽  
Author(s):  
Fenfang Chen ◽  
Xia Lin ◽  
Pinglong Xu ◽  
Zhengmao Zhang ◽  
Yanzhen Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Mesenchymal Stem Cell ◽  
Nuclear Export ◽  
Stem Cell Differentiation ◽  
Bmp Signaling ◽  
Dependent Manner ◽  
Mesenchymal Stem Cell Differentiation

Bone morphogenetic proteins (BMPs) play vital roles in regulating stem cell maintenance and differentiation. BMPs can induce osteogenesis and inhibit myogenesis of mesenchymal stem cells. Canonical BMP signaling is stringently controlled through reversible phosphorylation and nucleocytoplasmic shuttling of Smad1, Smad5, and Smad8 (Smad1/5/8). However, how the nuclear export of Smad1/5/8 is regulated remains unclear. Here we report that the Ran-binding protein RanBP3L acts as a nuclear export factor for Smad1/5/8. RanBP3L directly recognizes dephosphorylated Smad1/5/8 and mediates their nuclear export in a Ran-dependent manner. Increased expression of RanBP3L blocks BMP-induced osteogenesis of mouse bone marrow-derived mesenchymal stem cells and promotes myogenic induction of C2C12 mouse myoblasts, whereas depletion of RanBP3L expression enhances BMP-dependent stem cell differentiation activity and transcriptional responses. In conclusion, our results demonstrate that RanBP3L, as a nuclear exporter for BMP-specific Smads, plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation.

scholarly journals Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Lauriane Pous ◽  
Sachin S. Deshpande ◽  
Suvra Nath ◽  
Szilvia Mezey ◽  
Subash C. Malik ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Neural Stem Cell ◽  
Subventricular Zone ◽  
Stem Cell Differentiation ◽  
Bmp Signaling

scholarly journals BMP signaling in mesenchymal stem cell differentiation and bone formation

2013 ◽  
Vol 06 (08) ◽  
pp. 32-52 ◽  
Author(s):  
Maureen Beederman ◽  
Joseph D. Lamplot ◽  
Guoxin Nan ◽  
Jinhua Wang ◽  
Xing Liu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Mesenchymal Stem Cell ◽  
Bone Formation ◽  
Stem Cell Differentiation ◽  
Bmp Signaling ◽  
Mesenchymal Stem Cell Differentiation
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