Circulating CD4+PD-1+ and CD8+PD-1+ T cells are profoundly decreased at the onset of fulminant type 1 diabetes and are restored by treatment, contrasting with CD4+CD25+FoxP3+ regulatory T cells

2017 ◽  
Vol 133 ◽  
pp. 10-12 ◽  
Author(s):  
Toshie Iijima ◽  
Kanako Kato ◽  
Teruo Jojima ◽  
Takanori Tomotsune ◽  
Maiko Fukushima ◽  
...  
2021 ◽  
pp. 108893
Author(s):  
Daisuke Chujo ◽  
Akitsu Kawabe ◽  
Maya Matsushita ◽  
Chiharu Tsutsumi ◽  
Fumitaka Haseda ◽  
...  

2019 ◽  
Vol 104 (10) ◽  
pp. 4282-4294 ◽  
Author(s):  
Mikako Takita ◽  
Erika Jimbo ◽  
Tomoyasu Fukui ◽  
Kaoru Aida ◽  
Akira Shimada ◽  
...  

Abstract Context There are scant reports on the pathological changes of the exocrine and endocrine pancreas in fulminant type 1 diabetes mellitus (FT1DM). Objective To clarify the distinct pathological changes in the exocrine as well as the endocrine pancreas shortly after onset of diabetes in FT1DM. Design The exocrine and endocrine pancreases of 3 patients with FT1DM and 17 nondiabetic controls were immunohistochemically examined for islet and exocrine tissue inflammation, infiltrating mononuclear cell (MNC) CD subtype, enterovirus capsid protein 1 (VP1) localization, and CXC chemokine ligand 10 (CXCL10) and CXC chemokine receptor 3 (CXCR3) expressions. Results The median frequency of insulitis in the 3 FT1DM pancreases was 60%. In the nondiabetic control pancreases, no insulitis was observed. In the islets of FT1DM, the numbers of CD45+, CD3+, CD8+, CD68+, and CD11c+ MNCs were significantly higher than those of the control group. In the exocrine pancreas of FT1DM, the numbers of CD3+ T cells, CD8+ T cells, CD68+ macrophages, and CD11c+ dendritic cells were significantly higher than those of the control group. Infiltrating CD8+ T cells, CD68+ macrophages, and CD11c+ dendritic cells were observed around exocrine acinar cells in FT1DM. There was a close association between VP1 and CXCL10 expression in pancreatic exocrine ductal cells and acinar cells as well as islet cells in FT1DM. CXCL10+ exocrine cells were surrounded by CXCR3+ T cells. Conclusion The pathological findings suggested that suppression of the activated CXCL10–CXCR3 axis in the exocrine as well as the endocrine pancreas is a novel therapeutic target in FT1DM and possibly in enterovirus-associated acute-onset type 1 diabetes.


2011 ◽  
Vol 139 (1-2) ◽  
pp. 80-86 ◽  
Author(s):  
Fumitaka Haseda ◽  
Akihisa Imagawa ◽  
Yuko Murase-Mishiba ◽  
Hiroyuki Sano ◽  
Suzue Hirano-Kuwata ◽  
...  

2008 ◽  
Vol 70 (5) ◽  
pp. 482-486
Author(s):  
Ikko KAJIHARA ◽  
Asako ICHIHARA ◽  
Jyunko HIGO ◽  
Masato KIDOU ◽  
Mikio TODAKA ◽  
...  

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