<i>Objective</i>:
To examine if the 2-hour value of an oral glucose tolerance test (OGTT) can predict
cognitive decline.
<p><i>Research design and methods</i>: This study is based on a subpopulation of the Finnish
population-based Health 2000 Survey, and its follow-up, the Health 2011 study. Altogether
961 individuals aged 45–74 (mean 55.6 years, 55.8% women) underwent OGTT in
2001–2002. Categorical verbal fluency, word-list learning, and word-list
delayed recall were tested at baseline and at follow-up in 2011. Statistical
analyses were performed with multivariable linear models adjusted for previously
reported risk factors for cognitive decline.</p>
<p><i>Results</i>:
A higher 2-hour glucose value in the OGTT at baseline predicted worse
performance (slope: -0.08, p=0.01) and greater decline (slope: -0.07, p=0.007) in
the word-list delayed recall test after 10 years. </p>
<p><i>Conclusions</i>:
Our results indicate that higher 2-hour glucose values in the OGTT predict a
decline in episodic memory after 10 years. </p>
Comment on Pareek et al. Enhanced Predictive Capability of a 1-Hour Oral Glucose Tolerance Test: A Prospective Population-Based Cohort Study. Diabetes Care 2018;41:171–177
