IDF Diabetes Atlas: Global estimates of undiagnosed diabetes in adults for 2021

AbstractObjectivesNumerous biological variation (BV) studies have been performed over the years, but the quality of these studies vary. The objectives of this study were to perform a systematic review and critical appraisal of BV studies on glycosylated albumin and to deliver updated BV estimates for glucose and HbA1c, including recently published high-quality studies such as the European Biological Variation study (EuBIVAS).MethodsSystematic literature searches were performed to identify BV studies. Nine publications not included in a previous review were identified; four for glycosylated albumin, three for glucose, and three for HbA1c. Relevant studies were appraised by the Biological Variation Data Critical Appraisal Checklist (BIVAC). Global BV estimates were derived by meta-analysis of BIVAC-compliant studies in healthy subjects with similar study design.ResultsOne study received BIVAC grade A, 2B, and 6C. In most cases, the C-grade was associated with deficiencies in statistical analysis. BV estimates for glycosylated albumin were: CVI=1.4% (1.2–2.1) and CVG=5.7% (4.7–10.6), whereas estimates for HbA1c, CVI=1.2% (0.3–2.5), CVG=5.4% (3.3–7.3), and glucose, CVI=5.0% (4.1–12.0), CVG=8.1% (2.7–10.8) did not differ from previously published global estimates.ConclusionsThe critical appraisal and rating of BV studies according to their methodological quality, followed by a meta-analysis, generate robust, and reliable BV estimates. This study delivers updated and evidence-based BV estimates for glycosylated albumin, glucose and HbA1c.

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Uncertainties in global estimates of plastic waste highlight the need for monitoring frameworks

Marine Pollution Bulletin ◽

10.1016/j.marpolbul.2021.112720 ◽

2021 ◽

Vol 171 ◽

pp. 112720

Author(s):

Micaela Edelson ◽

Daniel Håbesland ◽

Rebecca Traldi

Keyword(s):

Plastic Waste ◽

Global Estimates

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Approaching Sea-Level Rise (SLR) Change: Strengthening Local Responses to Sea-Level Rise and Coping with Climate Change in Northern Mozambique

Journal of Marine Science and Engineering ◽

10.3390/jmse9020205 ◽

2021 ◽

Vol 9 (2) ◽

pp. 205

Author(s):

Serafino Afonso Rui Mucova ◽

Ulisses Miranda Azeiteiro ◽

Walter Leal Filho ◽

Carina Lurdes Lopes ◽

João Miguel Dias ◽

...

Keyword(s):

Ecosystem Services ◽

Sea Level Rise ◽

Sea Level ◽

North Coast ◽

Coastal Regions ◽

Mean Sea Level ◽

Representative Concentration Pathways ◽

Local Responses ◽

Ipcc Report ◽

Global Estimates

Mean sea-level is expected to rise significantly by 2100 in all scenarios, including those compatible with the objectives of the Paris Climate Agreement. Global sea level rise projections indicate devastating implications for populations, ecosystem services and biodiversity. The implications of the sea-level rise (SLR) on low-lying islands and coastal regions and communities are substantial and require deep-rooted coping measures. In the absence of adequate responses for coping, Mozambique is expected to record huge losses, with an impact on the economy and development in many sectors of its coastal regions mainly in northern Mozambique. This research aimed to perform projections on SLR in Mozambique, and to understand its role and implications on the north coast of the country. SLR was estimated through the analysis of model outputs that support the global estimates of the fifth IPCC report near the Mozambican coast, for each of the four representative concentration pathways (RCPs) scenarios. Regional coastline retreat and coastal erosion were estimated through the results of global sandy coastlines projections developed by Vousdoukas. Mean sea-level rise projections indicate that regional estimates for the Mozambican coast are relative higher than global estimates (~0.05 m) for all representative concentration pathways (RCPs). Yet, we highlight significant differences in sea-level rises of 0.5 m, 0.7 m or 1.0 m by 2100 compared to the global mean. It is expected that with the increase in the mean sea level in the northern part of the Mozambican coast, erosive effects will increase, as well as the retreat of the coastline until 2100. With this, the tourism sector, settlements, ecosystem services and local populations are expected to be significantly affected by 2050, with increased threats in 2100 (RCP4.5, RCP8.5). Local responses for coping are proposed and properly discussed for the RCP4.5 and RCP8.5 scenarios through 2100.

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