Metastatic hepatocellular carcinoma cured by exclusive systemic antiangiogenic therapy: Two cases along with tumor molecular profiles

2021 ◽  
Author(s):  
Alice Boilève ◽  
Cristina Smolenschi ◽  
Alina Fuerea ◽  
Antoine Hollebecque ◽  
Valérie Boige
Keyword(s):  
Hepatocellular Carcinoma ◽  
Antiangiogenic Therapy ◽  
Metastatic Hepatocellular Carcinoma ◽  
Molecular Profiles

scholarly journals The Role of Endoglin in Hepatocellular Carcinoma

2021 ◽  
Vol 22 (6) ◽  
pp. 3208
Author(s):  
Kuo-Shyang Jeng ◽  
I-Shyan Sheen ◽  
Shu-Sheng Lin ◽  
Chuen-Miin Leu ◽  
Chiung-Fang Chang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Diseases ◽  
Transforming Growth Factor ◽  
Antiangiogenic Therapy ◽  
Transforming Growth Factor Β ◽  
Postoperative Recurrence ◽  
Transmembrane Glycoprotein ◽  
Early Progression

Endoglin (CD105) is a type-1 integral transmembrane glycoprotein and coreceptor for transforming growth factor-β (TGF-β) ligands. The endoglin/TGF-β signaling pathway regulates hemostasis, cell proliferation/migration, extracellular matrix (ECM) synthesis and angiogenesis. Angiogenesis contributes to early progression, invasion, postoperative recurrence, and metastasis in hepatocellular carcinoma (HCC), one of the most widespread malignancies globally. Endoglin is overexpressed in newly formed HCC microvessels. It increases microvessel density in cirrhotic and regenerative HCC nodules. In addition, circulating endoglin is present in HCC patients, suggesting potential for use as a diagnostic or prognostic factor. HCC angiogenesis is dynamic and endoglin expression varies by stage. TRC105 (carotuximab) is an antibody against endoglin, and three of its clinical trials were related to liver diseases. A partial response was achieved when combining TRC105 with sorafenib. Although antiangiogenic therapy still carries some risks, combination therapy with endoglin inhibitors or other targeted therapies holds promise.

Life‐threatening haemorrhage from a sternal metastatic hepatocellular carcinoma

2000 ◽  
Vol 15 (6) ◽  
pp. 684-687 ◽  
Author(s):  
Chih‐Yen Chen ◽  
Gar‐Yang Chau ◽  
Sang‐Hue Yen ◽  
Yu‐Hsi Hsieh ◽  
Yee Chao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Life Threatening ◽  
Metastatic Hepatocellular Carcinoma

scholarly journals Metastatic Hepatocellular Carcinoma in the Tympanic Membrane

2010 ◽  
Vol 41 (2) ◽  
pp. 272-274 ◽  
Author(s):  
Z.-S. Wu ◽  
S.-C. Li ◽  
H.-C. Ho ◽  
J.-E. Tseng ◽  
Y.-H. Lin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tympanic Membrane ◽  
Metastatic Hepatocellular Carcinoma

Sustained Complete Remission of Metastatic Hepatocellular Carcinoma with Single Agent Sorafenib

2012 ◽  
Vol 44 (1) ◽  
pp. 98-101 ◽  
Author(s):  
Premal D. Lulla ◽  
Jonathan E. Brammer ◽  
Salman Bandeali ◽  
Garret R. Lynch
Keyword(s):  
Hepatocellular Carcinoma ◽  
Complete Remission ◽  
Single Agent ◽  
Metastatic Hepatocellular Carcinoma

scholarly journals A case of metastatic hepatocellular carcinoma of the maxillary sinus.

2001 ◽  
Vol 47 (1) ◽  
pp. 19-21 ◽  
Author(s):  
Yoshikazu KAMINO ◽  
Hiroyuki OKADA ◽  
Hitoshi NISHIMURA ◽  
Yoshiaki AKIMOTO ◽  
Hirotsugu YAMAMOTO ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Maxillary Sinus ◽  
Metastatic Hepatocellular Carcinoma
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