Genomic analysis reveals recurrent deletion of HNRNPK and SOCS1 in mycosis fungoides

2018 ◽  
Vol 101 ◽  
pp. S7
Author(s):  
Armando Bastidas Torres ◽  
Davy Cats ◽  
Hailiang Mei ◽  
Karoly Szuhai ◽  
Rein Willemze ◽  
...  
Keyword(s):  
Mycosis Fungoides ◽  
Genomic Analysis ◽  
Recurrent Deletion

scholarly journals Genomic analysis reveals recurrent deletion of JAK-STAT signaling inhibitorsHNRNPKandSOCS1in mycosis fungoides

2018 ◽  
Vol 57 (12) ◽  
pp. 653-664 ◽  
Author(s):  
Armando N. Bastidas Torres ◽  
Davy Cats ◽  
Hailiang Mei ◽  
Karoly Szuhai ◽  
Rein Willemze ◽  
...  
Keyword(s):  
Mycosis Fungoides ◽  
Genomic Analysis ◽  
Stat Signaling ◽  
Recurrent Deletion

scholarly journals Genomic analysis of mycosis fungoides and Sézary syndrome identifies recurrent alterations in TNFR2

2015 ◽  
Vol 47 (9) ◽  
pp. 1056-1060 ◽  
Author(s):  
Alexander Ungewickell ◽  
Aparna Bhaduri ◽  
Eon Rios ◽  
Jason Reuter ◽  
Carolyn S Lee ◽  
...  
Keyword(s):  
Mycosis Fungoides ◽  
Genomic Analysis ◽  
Sézary Syndrome ◽  
Sezary Syndrome

Array-based comparative genomic hybridization in early-stage mycosis fungoides: Recurrent deletion of tumor suppressor genesBCL7A, SMAC/DIABLO, andRHOF

2008 ◽  
Vol 47 (12) ◽  
pp. 1067-1075 ◽  
Author(s):  
Angelo Carbone ◽  
Laura Bernardini ◽  
Francesco Valenzano ◽  
Irene Bottillo ◽  
Clara De Simone ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Mycosis Fungoides ◽  
Comparative Genomic Hybridization ◽  
Early Stage ◽  
Comparative Genomic ◽  
Genomic Hybridization ◽  
Recurrent Deletion

Genomic analysis of sites that present somatic mutations in mice

2018 ◽  
Author(s):  
Katia Avina-Padilla
Keyword(s):  
Mammalian Species ◽  
Genetic Material ◽  
Genomic Analysis ◽  
Genomic Rearrangements ◽  
Evolutionary Information ◽  
Phylogenetic Studies ◽  
Dna Fragment ◽  
Functional Relevance ◽  
Recurrent Deletion ◽  
Data Banks

The recognition that genomes not only contain all the genetic material of a particular organism, but also have their historical information, has increased the range of phylogenetic studies, which provide evolutionary information. The development of complete genome sequencing techniques, in conjunction with the development of bioinformatics has led to a vertiginous growth in the amount of information deposited in the data banks, and in novel tools for analysis. Genomic analyzes allow us to obtain a comprehensive study of the functioning, content, evolution and origin of genomes.  It has been determined that there are dramatic rearrangements in the genomes, thus demonstrating genomic plasticity. It has been concluded that genomic rearrangements can occur as a consequence of events in which sites of small or large regions within the genome can be deleted, moved, exchanged, or inserted. Within these mentioned events are the deletions or deletions that consist in the loss of a DNA fragment of a chromosome, the size includes a range so diverse ranging from a nucleotide to large cytogenetically visible regions. There is a large number of studies that indicate that in various animal groups there are species in which genomic rearrangements occur during development whose functional relevance is still unknown. This project aims to focus on the study of recurrent deletion sites using the mouse as a study model with the main objective of identifying, characterizing and evaluating the presence of these genomic rearrangements in different genomes of mammals using the mouse genome as a study model for determine its possible functional and evolutionary relevance. The results obtained from this proposal will allow us to generate a general overview of the role played by these sequences, their possible correlation with the genome of other mammalian species will allow us to generate phylogenetic reconstructions.

Genomic analysis of C-type lectins

2002 ◽  
Vol 69 ◽  
pp. 59-72 ◽  
Author(s):  
Kurt Drickamer ◽  
Andrew J. Fadden
Keyword(s):  
Biological Effects ◽  
Cell Signalling ◽  
Genomic Analysis ◽  
Binding Activity ◽  
Immunoglobulin Superfamily ◽  
Carbohydrate Binding ◽  
Carbohydrate Recognition ◽  
Calcium Dependent ◽  
Binding Domains ◽  
Carbohydrate Recognition Domains

Many biological effects of complex carbohydrates are mediated by lectins that contain discrete carbohydrate-recognition domains. At least seven structurally distinct families of carbohydrate-recognition domains are found in lectins that are involved in intracellular trafficking, cell adhesion, cell–cell signalling, glycoprotein turnover and innate immunity. Genome-wide analysis of potential carbohydrate-binding domains is now possible. Two classes of intracellular lectins involved in glycoprotein trafficking are present in yeast, model invertebrates and vertebrates, and two other classes are present in vertebrates only. At the cell surface, calcium-dependent (C-type) lectins and galectins are found in model invertebrates and vertebrates, but not in yeast; immunoglobulin superfamily (I-type) lectins are only found in vertebrates. The evolutionary appearance of different classes of sugar-binding protein modules parallels a development towards more complex oligosaccharides that provide increased opportunities for specific recognition phenomena. An overall picture of the lectins present in humans can now be proposed. Based on our knowledge of the structures of several of the C-type carbohydrate-recognition domains, it is possible to suggest ligand-binding activity that may be associated with novel C-type lectin-like domains identified in a systematic screen of the human genome. Further analysis of the sequences of proteins containing these domains can be used as a basis for proposing potential biological functions.

Mycosis fungoides with spontaneously regressing CD30-positive tumorous lesions

1996 ◽  
Vol 21 (5) ◽  
pp. 370-373 ◽  
Author(s):  
S.L. WOODROW ◽  
T. BASARAB ◽  
R. RUSSELL JONES
Keyword(s):  
Mycosis Fungoides

Mycosis fungoides associated with unusual epidermal hyperplasia

1996 ◽  
Vol 21 (1) ◽  
pp. 61-64 ◽  
Author(s):  
L. PUIG ◽  
E. MUSULEN ◽  
M.-T. FERNANDEZ-FIGUERAS ◽  
J. MIRALLES ◽  
D. SITJAS ◽  
...  
Keyword(s):  
Mycosis Fungoides ◽  
Epidermal Hyperplasia

Mycosis fungoides? Sezary syndrome

1970 ◽  
Vol 101 (2) ◽  
pp. 244-246 ◽  
Author(s):  
H. H. Roenigk
Keyword(s):  
Mycosis Fungoides ◽  
Sézary Syndrome ◽  
Sezary Syndrome
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