Mild water restriction with or without urea for the longterm treatment of syndrome of inappropriate antidiuretic hormone secretion (SIADH): Can urine osmolality help the choice?

2018 ◽  
Vol 48 ◽  
pp. 89-93 ◽  
Author(s):  
G. Decaux ◽  
F. Gankam Kengne ◽  
B. Couturier ◽  
W. Musch ◽  
A. Soupart ◽  
...  
Keyword(s):  
Antidiuretic Hormone ◽  
Hormone Secretion ◽  
Urine Osmolality ◽  
Water Restriction ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion ◽  
Longterm Treatment

Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated With Congenital Hydrocephalus in a Dog

2009 ◽  
Vol 45 (5) ◽  
pp. 249-252 ◽  
Author(s):  
Robert E. Shiel ◽  
Manuel Pinilla ◽  
Carmel T. Mooney
Keyword(s):  
Antidiuretic Hormone ◽  
Hormone Secretion ◽  
Diagnostic Testing ◽  
Clinical Signs ◽  
Abnormal Behavior ◽  
Water Restriction ◽  
Current Case ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion ◽  
Truncal Ataxia

A 13-month-old, male bichon frise was examined for the investigation of intermittent seizures, ataxia, abnormal behavior, polyuria, and polydipsia. At presentation, clinical and neurological examinations were unremarkable with the exception of mild truncal ataxia and a domed skull. Severe hyponatremia and hypoosmolality were identified, and following diagnostic testing a diagnosis of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) was made. Magnetic resonance imaging revealed changes consistent with severe hydrocephalus. Water restriction resulted in increased serum osmolality and a reduction in severity of clinical signs. The current case report documents SIADH associated with hydrocephalus in a dog. Structural brain disease should be excluded before a diagnosis of idiopathic SIADH is made.

Syndrome of Inappropriate Antidiuretic Hormone Secretion in a Cat

2010 ◽  
Vol 46 (6) ◽  
pp. 425-432 ◽  
Author(s):  
Kristin Cameron ◽  
Alexander Gallagher
Keyword(s):  
Antidiuretic Hormone ◽  
Hormone Secretion ◽  
Clinical Signs ◽  
Urine Osmolality ◽  
Electrolyte Imbalance ◽  
Fluid Restriction ◽  
Severe Hyponatremia ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion ◽  
Serum And Urine

A 3-year-old, spayed female, domestic shorthaired cat was presented for evaluation of liver disease. Following anesthesia, laparoscopy, and medical therapy, the cat developed severe hyponatremia that was unresponsive to fluid therapy. Further evaluation of serum and urine osmolality determined that the cat fulfilled the criteria for syndrome of inappropriate antidiuretic hormone secretion. Treatment with fluid restriction resulted in resolution of the hyponatremia and clinical signs associated with the electrolyte imbalance.

scholarly journals Early water intake restriction to prevent inappropriate antidiuretic hormone secretion following transsphenoidal surgery: low BMI predicts postoperative SIADH

2014 ◽  
Vol 171 (6) ◽  
pp. 711-716 ◽  
Author(s):  
Junko Matsuyama ◽  
Hidetoshi Ikeda ◽  
Shunsuke Sato ◽  
Koh Yamamoto ◽  
Genichiro Ohashi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Antidiuretic Hormone ◽  
Water Intake ◽  
Serum Sodium ◽  
Transsphenoidal Surgery ◽  
Hormone Secretion ◽  
Water Restriction ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion ◽  
Daily Urine

ObjectiveThe goals of this study were to assess the incidence of and risk factors for the syndrome of inappropriate antidiuretic hormone secretion (SIADH) in patients following transsphenoidal surgery (TSS), and to validate the effectiveness of early prophylactic restriction of water intake.DesignRetrospective analysis was performed for 207 patients who had undergone TSS, including 156 patients not placed on early prophylactic water restriction. Sixty-four patients received treatment for SIADH.MethodsWe compared the incidence of SIADH between patients with and without early water intake restriction, and analyzed various risk factors for SIADH using statistical analyses.ResultsBMI was significantly lower for patients with SIADH than for those patients without SIADH. Statistical analysis revealed that the threshold BMI predicting SIADH was 26. Serum sodium levels on postoperative days 5–10 and daily urine volumes on postoperative days 5–10 were significantly lower in patients with SIADH than in those without SIADH. Postoperative body weight loss on days 6, 8, 10, and 11 was significantly higher in patients with SIADH. The incidence of SIADH after starting prophylactic water intake restriction (14%) was significantly lower than the rate before early water restriction (38%; P<0.05).ConclusionsSIADH is relatively common after TSS, and serum sodium concentrations and daily urine volumes should be carefully monitored. Patients with low preoperative BMI should be closely observed, as this represented a significant preoperative risk factor for SIADH. Early prophylactic water intake restriction appears effective at preventing postoperative SIADH.

scholarly journals Small cell carcinoma of the cervix complicated by syndrome of inappropriate antidiuretic hormone secretion: a case report

2021 ◽  
Vol 49 (2) ◽  
pp. 030006052098565
Author(s):  
Cai-Fu Zhao ◽  
Su-Fen Zhao ◽  
Ze-Qing Du
Keyword(s):  
Cell Carcinoma ◽  
Antidiuretic Hormone ◽  
Small Cell Carcinoma ◽  
Poor Prognosis ◽  
Hormone Secretion ◽  
Clinical Manifestations ◽  
Small Cell ◽  
Laboratory Examination ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion

Small cell carcinoma of the cervix is a rare malignant tumor in the clinical setting. Clinical manifestations of this tumor are mostly similar to those of normal types of cervical cancer. Small cell carcinoma of the cervix only shows symptoms of neuroendocrine tumors, such as syndrome of inappropriate antidiuretic hormone secretion (SIADH). Most of the hyponatremia caused by SIADH can be managed after removal of the cause. Hyponatremia is a predictor of poor prognosis and can be used as an indicator of partial recurrence. We report a case of small cell carcinoma of the cervix complicated by SIADH. Our patient presented with irregular vaginal bleeding after menopause. After one cycle of chemotherapy, there was trembling of the limbs, and a laboratory examination showed low Na+ and low Cl− levels. After limited water intake, intravenous hypertonic saline, and intermittent diuretic treatment, the patient’s blood Na+ levels returned to normal. After a radical operation, the above-mentioned symptoms disappeared.

scholarly journals Syringomyelia associated with inappropriate antidiuretic hormone secretion

2014 ◽  
Vol 2014 (apr11 1) ◽  
pp. bcr2013202575-bcr2013202575
Author(s):  
P. Barros Alcalde ◽  
A. Gonzalez Quintela ◽  
M. Pena Seijo ◽  
A. Pose-Reino
Keyword(s):  
Antidiuretic Hormone ◽  
Hormone Secretion ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion
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