Erratum to ‘Structure–activity relationships of novel P2-receptor antagonists structurally related to Reactive Blue 2’. [European Journal of Medicinal Chemistry 40 (12) 2005, 1262–1276]

2006 ◽  
Vol 41 (3) ◽  
pp. 435 ◽  
Author(s):  
Markus Glänzel ◽  
Ralph Bültmann ◽  
Klaus Starke ◽  
August W. Frahm
Keyword(s):  
Medicinal Chemistry ◽  
P2 Receptor ◽  
Receptor Antagonists ◽  
Reactive Blue 2 ◽  
Structure Activity Relationships ◽  
Structure Activity

Structure-Activity Relationships of Suramin and Pyridoxal-5-phosphate Derivatives as P2 Receptor Antagonists

2002 ◽  
Vol 8 (26) ◽  
pp. 2371-2399 ◽  
Author(s):  
Gunter Lambrecht ◽  
Kirsten Braun ◽  
Susanne Damer ◽  
Matthias Ganso ◽  
Caren Hildebrandt ◽  
...  
Keyword(s):  
P2 Receptor ◽  
Receptor Antagonists ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Synthesis, Antiprotozoal Activity, and Cheminformatic Analysis of 2-Phenyl-2H-Indazole Derivatives

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2145
Author(s):  
Karen Rodríguez-Villar ◽  
Lilián Yépez-Mulia ◽  
Miguel Cortés-Gines ◽  
Jacobo David Aguilera-Perdomo ◽  
Edgar A. Quintana-Salazar ◽  
...  
Keyword(s):  
Phenyl Ring ◽  
Medicinal Chemistry ◽  
Structural Features ◽  
Pharmacological Properties ◽  
Antiprotozoal Activity ◽  
One Pot ◽  
Biological Assays ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Synthetic Methodologies

Indazole is an important scaffold in medicinal chemistry. At present, the progress on synthetic methodologies has allowed the preparation of several new indazole derivatives with interesting pharmacological properties. Particularly, the antiprotozoal activity of indazole derivatives have been recently reported. Herein, a series of 22 indazole derivatives was synthesized and studied as antiprotozoals. The 2-phenyl-2H-indazole scaffold was accessed by a one-pot procedure, which includes a combination of ultrasound synthesis under neat conditions as well as Cadogan’s cyclization. Moreover, some compounds were derivatized to have an appropriate set to provide structure-activity relationships (SAR) information. Whereas the antiprotozoal activity of six of these compounds against E. histolytica, G. intestinalis, and T. vaginalis had been previously reported, the activity of the additional 16 compounds was evaluated against these same protozoa. The biological assays revealed structural features that favor the antiprotozoal activity against the three protozoans tested, e.g., electron withdrawing groups at the 2-phenyl ring. It is important to mention that the indazole derivatives possess strong antiprotozoal activity and are also characterized by a continuous SAR.

Structure–activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists

2004 ◽  
Vol 14 (15) ◽  
pp. 4099-4102 ◽  
Author(s):  
Rosa Arienzo ◽  
David E Clark ◽  
Sue Cramp ◽  
Stephen Daly ◽  
Hazel J Dyke ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Melanin Concentrating Hormone
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