Design, synthesis and biological evaluation of [1,2,3]triazolo[4,5- d ]pyrimidine derivatives possessing a hydrazone moiety as antiproliferative agents

2016 ◽  
Vol 124 ◽  
pp. 967-980 ◽  
Author(s):  
Zhong-Hua Li ◽  
Dong-Xiao Yang ◽  
Peng-Fei Geng ◽  
Ji Zhang ◽  
Hao-Ming Wei ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Pyrimidine Derivatives ◽  
Design Synthesis ◽  
Antiproliferative Agents ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis, and biological evaluation of new thiazolo[5,4-d]pyrimidine derivatives as potent antiproliferative agents

MedChemComm ◽  
2017 ◽  
Vol 8 (8) ◽  
pp. 1655-1658 ◽  
Author(s):  
Zhong-Hua Li ◽  
Xue-Qi Liu ◽  
Peng-Fei Geng ◽  
Jin-Lian Ma ◽  
Tao-Qian Zhao ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Pyrimidine Derivative ◽  
Pyrimidine Derivatives ◽  
Design Synthesis ◽  
Antiproliferative Agents ◽  
Potent Inhibition ◽  
Synthesis And Biological Evaluation

The thiazolo[5,4-d]pyrimidine derivative 7i exhibited potent inhibition against MGC-803 and HGC-27 with IC50 values of 4.64 and 5.07 μM, respectively and around 12-fold selectivity between MGC-803 and GES-1.

Naphthoflavones as Antiproliferative Agents: Design, Synthesis and Biological Evaluation

2016 ◽  
Vol 16 (7) ◽  
pp. 881-890 ◽  
Author(s):  
Dinesh Kumar ◽  
Onkar Singh ◽  
Kunal Nepali ◽  
PMS Bedi ◽  
Arem Qayum ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Antiproliferative Agents ◽  
Synthesis And Biological Evaluation

Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of RET: Design, synthesis and biological evaluation

2020 ◽  
Vol 206 ◽  
pp. 112691
Author(s):  
Naga Rajiv Lakkaniga ◽  
Naresh Gunaganti ◽  
Lingtian Zhang ◽  
Binyam Belachew ◽  
Brendan Frett ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Pyrimidine Derivatives ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of aryl pyrimidine derivatives as potential leishmanicidal agents

2013 ◽  
Vol 23 (18) ◽  
pp. 5235-5238 ◽  
Author(s):  
S.N. Suryawanshi ◽  
Santosh Kumar ◽  
Rahul Shivahare ◽  
Susmita Pandey ◽  
Avinash Tiwari ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Pyrimidine Derivatives ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Symmetrical α-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation

2010 ◽  
Vol 20 (9) ◽  
pp. 2733-2739 ◽  
Author(s):  
Romeo Romagnoli ◽  
Pier Giovanni Baraldi ◽  
Olga Cruz-Lopez ◽  
Carlota Lopez Cara ◽  
Maria Dora Carrion ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Antiproliferative Agents ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and biological evaluation of novel nitric oxide-donating podophyllotoxin derivatives as potential antiproliferative agents against multi-drug resistant leukemia cells

RSC Advances ◽  
2018 ◽  
Vol 8 (60) ◽  
pp. 34266-34274 ◽  
Author(s):  
Lei Zhang ◽  
Ying Rong ◽  
Jie Zheng ◽  
Chengli Yang ◽  
Yongzheng Chen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Antiproliferative Activity ◽  
Biological Evaluation ◽  
Leukemia Cells ◽  
Drug Resistant ◽  
Design Synthesis ◽  
Antiproliferative Agents ◽  
Podophyllotoxin Derivatives ◽  
Synthesis And Biological Evaluation

Conjugate S1 exhibited potential antiproliferative activity against multi-drug resistant leukemia cells.

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