Novel 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives as potent anticancer agents – Synthesis, molecular structure, QSAR studies and metabolic stability

2017 ◽  
Vol 138 ◽  
pp. 357-370 ◽  
Author(s):  
Aneta Pogorzelska ◽  
Jarosław Sławiński ◽  
Beata Żołnowska ◽  
Krzysztof Szafrański ◽  
Anna Kawiak ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Anticancer Agents ◽  
Metabolic Stability ◽  
Qsar Studies ◽  
Guanidine Derivatives

scholarly journals Synthesis, Molecular Structure, Metabolic Stability and QSAR Studies of a Novel Series of Anticancer N-Acylbenzenesulfonamides

Molecules ◽  
2015 ◽  
Vol 20 (10) ◽  
pp. 19101-19129 ◽  
Author(s):  
Beata Żołnowska ◽  
Jarosław Sławiński ◽  
Mariusz Belka ◽  
Tomasz Bączek ◽  
Anna Kawiak ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Metabolic Stability ◽  
Qsar Studies

Synthesis, cytotoxic activity, and 2D- and 3D-QSAR studies of 19-carboxyl-modified novel isosteviol derivatives as potential anticancer agents

2017 ◽  
Vol 89 (6) ◽  
pp. 870-887 ◽  
Author(s):  
Cong-Jun Liu ◽  
Tao Zhang ◽  
Shu-Ling Yu ◽  
Xing-Jie Dai ◽  
Ya Wu ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Anticancer Agents ◽  
3D Qsar ◽  
Qsar Studies ◽  
2D And 3D

QSAR Studies to Predict Activity of HSP90 Inhibitors

2021 ◽  
Vol 21 ◽  
Author(s):  
Vaishali M. Patil ◽  
Neeraj Masand ◽  
Satya P. Gupta ◽  
Brian S. J. Blagg
Keyword(s):  
Anticancer Agents ◽  
Heat Shock Protein 90 ◽  
New Drugs ◽  
Signaling Proteins ◽  
Hsp90 Inhibitors ◽  
Oncogenic Signaling ◽  
Qsar Studies ◽  
Sar Studies ◽  
Promising Target ◽  
Qsar Models

: Heat shock protein 90 (HSP90) is a multichaperone complex that mediates the maturation and stability of a variety of oncogenic signaling proteins. HSP90 has emerged as a promising target for the development of anticancer agents. Heterocyclic chemical moieties with HSP90 inhibitory activity were studied continuously during the last decades, and resulting data were applied by medicinal chemists to design and develop new drugs. Their structure-activity relationship (SAR) studies and QSAR models have been derived to assist the current drug development process. The QSAR models are obtained via multiple linear regression (MLR) and non-linear approaches. Interpretation of the reported model highlights the core template required to design novel, potent HSP90 inhibitors to be used as anticancer agents.

ChemInform Abstract: Synthesis and QSAR Studies of 16-(3-Methoxy-4-substituted benzylidene) Androstene Derivatives as Anticancer Agents.

ChemInform ◽  
2010 ◽  
Vol 41 (47) ◽  
pp. no-no
Author(s):  
Sonal Dubey ◽  
Parmeet Kaur ◽  
Dharam Paul Jindal ◽  
Yalamanchili Darji Satyanarayan ◽  
Poonam Piplani
Keyword(s):  
Anticancer Agents ◽  
Qsar Studies

Synthesis, Evaluation and QSAR Studies of 16-(4 & 3,4-Substituted) Benzylidene Androstene Derivatives as Anticancer Agents

2008 ◽  
Vol 4 (3) ◽  
pp. 229-236 ◽  
Author(s):  
S. Dubey ◽  
P. Kaur ◽  
D. Jindal ◽  
Y. Satyanarayan ◽  
P. Piplani
Keyword(s):  
Anticancer Agents ◽  
Qsar Studies

Design, modification and 3D QSAR studies of novel naphthalin-containing pyrazoline derivatives with/without thiourea skeleton as anticancer agents

2013 ◽  
Vol 21 (5) ◽  
pp. 1050-1063 ◽  
Author(s):  
Wen Yang ◽  
Yang Hu ◽  
Yu-Shun Yang ◽  
Fei Zhang ◽  
Yan-Bin Zhang ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
3D Qsar ◽  
Design Modification ◽  
Qsar Studies
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