A potent photoreactive general anesthetic with novel binding site selectivity for GABAA receptors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112261 ◽

2020 ◽

Vol 194 ◽

pp. 112261 ◽

Author(s):

Abdelrahman R. Shalabi ◽

Zhiyi Yu ◽

Xiaojuan Zhou ◽

Youssef Jounaidi ◽

Hanwen Chen ◽

...

Keyword(s):

Binding Site ◽

Gabaa Receptors ◽

General Anesthetic ◽

Site Selectivity

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Faculty Opinions recommendation of Mapping the contribution of beta3-containing GABAA receptors to volatile and intravenous general anesthetic actions.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1071869.524799 ◽

2007 ◽

Author(s):

Andrew Jenkins

Keyword(s):

Gabaa Receptors ◽

General Anesthetic

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Faculty Opinions recommendation of A propofol binding site on mammalian GABAA receptors identified by photolabeling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718116532.793490946 ◽

2014 ◽

Author(s):

Jean-Pierre Changeux

Keyword(s):

Binding Site ◽

Gabaa Receptors

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Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay

Oncogene ◽

10.1038/sj.onc.1202041 ◽

1998 ◽

Vol 16 (19) ◽

pp. 2527-2539 ◽

Author(s):

Charles J Di Como ◽

Carol Prives

Keyword(s):

Binding Site ◽

Temperature Sensitivity ◽

Human Tumor ◽

Site Selectivity

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ChemInform Abstract: Benzylidene-Substituted Imidazo-Thiazole-, Thiazine and -Thiazepine Derivatives: A New Class of Ligands for the Benzodiazepine Binding Site of GABAA Receptors.

10.1002/chin.199718154 ◽

2010 ◽

Vol 28 (18) ◽

pp. no-no

Author(s):

U. GEIS ◽

K. KIEC-KONONOWICZ ◽

C. E. MUELLER

Keyword(s):

Binding Site ◽

Gabaa Receptors ◽

New Class ◽

Benzodiazepine Binding

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Alcohol Selectivity of β3-Containing GABAA Receptors: Evidence for a Unique Extracellular Alcohol/Imidazobenzodiazepine Ro15-4513 Binding Site at the α+β- Subunit Interface in αβ3δ GABAA Receptors

Neurochemical Research ◽

10.1007/s11064-014-1243-0 ◽

2014 ◽

Vol 39 (6) ◽

pp. 1118-1126 ◽

Author(s):

M. Wallner ◽

H. J. Hanchar ◽

R. W. Olsen

Keyword(s):

Binding Site ◽

Gabaa Receptors ◽

Subunit Interface

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Azaflavones compared to flavones as ligands to the benzodiazepine binding site of brain GABAA receptors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2008.09.092 ◽

2008 ◽

Vol 18 (21) ◽

pp. 5713-5716 ◽

Author(s):

Jakob Nilsson ◽

Elsebet Østergaard Nielsen ◽

Tommy Liljefors ◽

Mogens Nielsen ◽

Olov Sterner

Keyword(s):

Binding Site ◽

Gabaa Receptors ◽

Benzodiazepine Binding

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Faculty Opinions recommendation of A propofol binding site on mammalian GABAA receptors identified by photolabeling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718116532.793484692 ◽

2013 ◽

Author(s):

Stuart Forman

Keyword(s):

Binding Site ◽

Gabaa Receptors

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Faculty Opinions recommendation of Identification of a putative binding site critical for general anesthetic activation of TRPA1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727427297.793530353 ◽

2017 ◽

Author(s):

Roderic Eckenhoff ◽

Kellie Woll

Keyword(s):

Binding Site ◽

General Anesthetic ◽

Putative Binding Site

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Faculty Opinions recommendation of Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABAA) receptors.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.738154795.793575797 ◽

2020 ◽

Author(s):

Gustav Akk

Keyword(s):

Binding Site ◽

Gabaa Receptors ◽

Photoaffinity Labeling ◽

Type A ◽

Steroid Binding

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Structural determinants of 5-HT1A versus 5-HT1D receptor binding site selectivity

European Journal of Pharmacology ◽

10.1016/0014-2999(91)90127-c ◽

1991 ◽

Vol 194 (1) ◽

pp. 83-90 ◽

Author(s):

Melissa A. Harrington ◽

Andrew J. Sleight ◽

Josef Pitha ◽

Stephen J. Peroutka

Keyword(s):

Binding Site ◽

Receptor Binding ◽

Structural Determinants ◽

Receptor Binding Site ◽

Site Selectivity

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