Discovery of first-in-class multi-target adenosine A2A receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents

2020 ◽  
Vol 201 ◽  
pp. 112478
Author(s):  
Costanza Ceni ◽  
Daniela Catarzi ◽  
Flavia Varano ◽  
Diego Dal Ben ◽  
Gabriella Marucci ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Antitumor Agents ◽  
Adenosine A2a Receptor ◽  
Carbonic Anhydrase Ix ◽  
Receptor Antagonists ◽  
Adenosine A2a Receptor Antagonists ◽  
A2a Receptor ◽  
Adenosine A2a ◽  
Potential Antitumor

scholarly journals Characterization of the trigeminovascular actions of several adenosine A2A receptor antagonists in an in vivo rat model of migraine

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Kristian A. Haanes ◽  
Alejandro Labastida-Ramírez ◽  
Kayi Y. Chan ◽  
René de Vries ◽  
Brian Shook ◽  
...  
Keyword(s):  
Rat Model ◽  
Adenosine A2a Receptor ◽  
Receptor Antagonists ◽  
Adenosine A2a Receptor Antagonists ◽  
A2a Receptor ◽  
Adenosine A2a

The Controversial Role of Adenosine A2A Receptor Antagonists as Neuro-protective Agents

2004 ◽  
Vol 4 (1) ◽  
pp. 35-45 ◽  
Author(s):  
Patrizia Popoli ◽  
David Blum ◽  
Annita Pintor ◽  
Maria Tebano ◽  
Claudio Frank ◽  
...  
Keyword(s):  
Adenosine A2a Receptor ◽  
Receptor Antagonists ◽  
Protective Agents ◽  
Adenosine A2a Receptor Antagonists ◽  
A2a Receptor ◽  
Adenosine A2a

Hit-to-lead optimization of a series of carboxamides of ethyl 2-amino-4-phenylthiazole-5-carboxylates as novel adenosine A2A receptor antagonists

2010 ◽  
Vol 20 (17) ◽  
pp. 5241-5244 ◽  
Author(s):  
Anette Graven Sams ◽  
Gitte Kobberøe Mikkelsen ◽  
Mogens Larsen ◽  
Lars Torup ◽  
Lise Tøttrup Brennum ◽  
...  
Keyword(s):  
Adenosine A2a Receptor ◽  
Lead Optimization ◽  
Receptor Antagonists ◽  
Adenosine A2a Receptor Antagonists ◽  
A2a Receptor ◽  
Adenosine A2a

The effects of adenosine A2A receptor antagonists on haloperidol-induced movement disorders in primates

2008 ◽  
Vol 200 (3) ◽  
pp. 393-401 ◽  
Author(s):  
Geoffrey B. Varty ◽  
Robert A. Hodgson ◽  
Annamarie J. Pond ◽  
Michael E. Grzelak ◽  
Eric M. Parker ◽  
...  
Keyword(s):  
Movement Disorders ◽  
Adenosine A2a Receptor ◽  
Receptor Antagonists ◽  
Adenosine A2a Receptor Antagonists ◽  
A2a Receptor ◽  
Adenosine A2a
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