Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections

2021 ◽  
Vol 216 ◽  
pp. 113337
Author(s):  
Hang Xu ◽  
Zhong-zuo Yan ◽  
Meng-bi Guo ◽  
Ran An ◽  
Xin Wang ◽  
...  
Keyword(s):  
Fungal Infections ◽  
Lead Optimization ◽  
Pharmacological Profile

Lead Optimization Generates CYP11B1 Inhibitors of Pyridylmethyl Isoxazole Type with Improved Pharmacological Profile for the Treatment of Cushing’s Disease

2017 ◽  
Vol 60 (12) ◽  
pp. 5086-5098 ◽  
Author(s):  
Juliette Emmerich ◽  
Chris J. van Koppen ◽  
Jens L. Burkhart ◽  
Qingzhong Hu ◽  
Lorenz Siebenbürger ◽  
...  
Keyword(s):  
Cushing’S Disease ◽  
Lead Optimization ◽  
Cushing's Disease ◽  
Pharmacological Profile

Fungal Infections Of The Nose And Paranasal Sinuses

1993 ◽  
Vol 26 (6) ◽  
pp. 1007-1035 ◽  
Author(s):  
Andrew Blitzer ◽  
William Lawson
Keyword(s):  
Paranasal Sinuses ◽  
Fungal Infections ◽  
Nose And Paranasal Sinuses

Unexplained GI Fungal Infections Seen in Arizona

2006 ◽  
Vol 39 (8) ◽  
pp. 66
Author(s):  
NANCY WALSH
Keyword(s):  
Fungal Infections

Wounded Troops Battle Invasive Fungal Infections

2012 ◽  
Vol 5 (8) ◽  
pp. 12
Author(s):  
PATRICE WENDLING
Keyword(s):  
Fungal Infections ◽  
Invasive Fungal Infections

In silico ADME, Bioactivity and Toxicity Parameters Calculation of Some Selected Anti-Tubercular Drugs

2016 ◽  
Vol 6 (6) ◽  
pp. 77 ◽  
Author(s):  
Shashank Shekhar Mishra ◽  
Chandra Shekhar Sharma ◽  
Hemendra Pratap Singh ◽  
Harshda Pandiya ◽  
Neeraj Kumar
Keyword(s):  
Antibiotic Resistance ◽  
In Silico ◽  
Bacillus Calmette Guerin ◽  
Computational Investigation ◽  
Pharmacological Profile ◽  
In Silico Toxicity ◽  
Is Development ◽  
Potent Drug ◽  
Minimal Resistance ◽  
Parameters Calculation

Tuberculosis, one of the most frequent infectious diseases, is caused by a mycobacterium tuberculosis bacteria and it infects several hundred million people each year, results in several million deaths annually. Because there is development of antibiotic resistance, the disease becomes incurable. So, in the absence of effective and potent drug with minimal resistance problems, the mortality rate increases annually. In this computational investigation, we performed In-silico ADME, bioactivity and toxicity parameters calculation of some selected anti-tuberculosis agents. To design a new molecule having good pharmacological profile, this study will provide the lead information.Key Words: Tuberculosis (TB), Bacillus Calmette-Guerin vaccine, TPSA, In Silico toxicity

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