Development of novel 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives as balanced multifunctional agents against Alzheimer's disease

2022 ◽  
pp. 114098
Author(s):  
Yichun Shi ◽  
Heng Zhang ◽  
Qing Song ◽  
Guangjun Yu ◽  
Zhuoling Liu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Multifunctional Agents

Design, synthesis and evaluation of novel bivalent β -carboline derivatives as multifunctional agents for the treatment of Alzheimer's disease

2018 ◽  
Vol 26 (13) ◽  
pp. 3812-3824 ◽  
Author(s):  
Yifan Zhao ◽  
Feng Ye ◽  
Jian Xu ◽  
Qinghong Liao ◽  
Lei Chen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Design Synthesis ◽  
Multifunctional Agents

Design and development of molecular hybrids of 2-pyridylpiperazine and 5-phenyl-1,3,4-oxadiazoles as potential multifunctional agents to treat Alzheimer's disease

2019 ◽  
Vol 183 ◽  
pp. 111707 ◽  
Author(s):  
Avanish Tripathi ◽  
Priyanka Kumari Choubey ◽  
Piyoosh Sharma ◽  
Ankit Seth ◽  
Prabhash Nath Tripathi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Design And Development ◽  
Molecular Hybrids ◽  
Multifunctional Agents

scholarly journals Synthesis, Molecular Docking, and Preliminary Evaluation of 2‐(1,2,3‐Triazoyl)benzaldehydes As Multifunctional Agents for the Treatment of Alzheimer's Disease

ChemMedChem ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. 610-622 ◽  
Author(s):  
Gabriel P. Costa ◽  
Rodolfo S. M. Baldinotti ◽  
Mariana G. Fronza ◽  
José Edmilson R. Nascimento ◽  
Ítalo F. C. Dias ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Docking ◽  
Preliminary Evaluation ◽  
Multifunctional Agents

Design, synthesis, and evaluation of isoflavone analogs as multifunctional agents for the treatment of Alzheimer's disease

2019 ◽  
Vol 168 ◽  
pp. 207-220 ◽  
Author(s):  
Dongmei Wang ◽  
Min Hu ◽  
Xinpeng Li ◽  
Dan Zhang ◽  
Chengjuan Chen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Design Synthesis ◽  
Multifunctional Agents

The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer’s disease

2019 ◽  
Vol 29 (19) ◽  
pp. 126625 ◽  
Author(s):  
Gaofeng Zhu ◽  
Keren Wang ◽  
Jian Shi ◽  
Pengfei Zhang ◽  
Dan Yang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Multifunctional Agents

scholarly journals Synthesis, molecular docking, and biological evaluation of novel 2-pyrazoline derivatives as multifunctional agents for the treatment of Alzheimer's disease

MedChemComm ◽  
2019 ◽  
Vol 10 (6) ◽  
pp. 1018-1026 ◽  
Author(s):  
Oya Unsal-Tan ◽  
Tuba Tüylü Küçükkılınç ◽  
Beyza Ayazgök ◽  
Ayla Balkan ◽  
Keriman Ozadali-Sari
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Docking ◽  
Biological Evaluation ◽  
Multifunctional Agents

A novel series of 2-pyrazoline derivatives were designed, synthesized, and evaluated for cholinesterase (ChE) inhibitory, Aβ anti-aggregating and neuroprotective activities.

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