Luteinizing hormone β-subunit gene (LHβ) polymorphism in infertility and endometriosis-associated infertility

2010 ◽  
Vol 151 (1) ◽  
pp. 66-69 ◽  
Author(s):  
Fernanda A. Mafra ◽  
Bianca Bianco ◽  
Denise M. Christofolini ◽  
Ângela M.B. Souza ◽  
Karina Zulli ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Β Subunit ◽  
Subunit Gene

scholarly journals Hypogonadotrophic hypogonadism due to a mutation in the luteinizing hormone β-subunit gene

2018 ◽  
Vol 33 (3) ◽  
pp. 638-641 ◽  
Author(s):  
Jae Won Song ◽  
Hyo-Jeong Hwang ◽  
Chang Min Lee ◽  
Gun Ha Park ◽  
Chul Sik Kim ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Β Subunit ◽  
Subunit Gene ◽  
Hypogonadotrophic Hypogonadism

scholarly journals Multiple Mechanisms for Pitx-1 Transactivation of a Luteinizing Hormone β Subunit Gene

2002 ◽  
Vol 277 (29) ◽  
pp. 26200-26207 ◽  
Author(s):  
Philippa Melamed ◽  
Mingshi Koh ◽  
Prema Preklathan ◽  
Ling Bei ◽  
Choy Hew
Keyword(s):  
Luteinizing Hormone ◽  
Β Subunit ◽  
Subunit Gene

Characterization of the luteinizing hormone beta (LH-β) subunit gene in the Indian river buffalo (Bubalus bubalis)

2008 ◽  
Vol 155 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Mallikarjuna Shivapura Basavarajappa ◽  
Sachinandan De ◽  
Manish Thakur ◽  
Tirtha Kumar Datta ◽  
Gaurav Dogra ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Bubalus Bubalis ◽  
River Buffalo ◽  
Β Subunit ◽  
Subunit Gene ◽  
Indian River

Genetic analysis of three polymorphic sites of the luteinizing hormone β-subunit gene in infertile Korean men with nonobstructive azoospermia

2003 ◽  
Vol 79 (3) ◽  
pp. 517-521 ◽  
Author(s):  
Suman Lee ◽  
Nam Keun Kim ◽  
Hyun-Joo Kim ◽  
Sook-Hwan Lee ◽  
Hye-Jin Jeong ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Genetic Analysis ◽  
Β Subunit ◽  
Subunit Gene ◽  
Nonobstructive Azoospermia

The role of the 3′ region of mammalian gonadotropin β subunit gene in the luteinizing hormone to chorionic gonadotropin evolution

2014 ◽  
Vol 382 (2) ◽  
pp. 781-790 ◽  
Author(s):  
Reut Gabay ◽  
Shelly Rozen ◽  
Albena Samokovlisky ◽  
Yehudit Amor ◽  
Rakefet Rosenfeld ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Chorionic Gonadotropin ◽  
Β Subunit ◽  
Subunit Gene

scholarly journals Hypogonadism in a Patient with Two Novel Mutations of the Luteinizing Hormone β-Subunit Gene Expressed in a Compound Heterozygous Form

2012 ◽  
Vol 97 (9) ◽  
pp. 3031-3038 ◽  
Author(s):  
Sabrina Basciani ◽  
Mikiko Watanabe ◽  
Stefania Mariani ◽  
Marina Passeri ◽  
Agnese Persichetti ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Compound Heterozygous ◽  
Β Subunit ◽  
Subunit Gene ◽  
Novel Mutations ◽  
Heterozygous Form

MiR-200b and miR-429 Function in Mouse Ovulation and Are Essential for Female Fertility

Science ◽  
2013 ◽  
Vol 341 (6141) ◽  
pp. 71-73 ◽  
Author(s):  
Hidetoshi Hasuwa ◽  
Jun Ueda ◽  
Masahito Ikawa ◽  
Masaru Okabe
Keyword(s):  
Luteinizing Hormone ◽  
Pituitary Gland ◽  
Transcriptional Repressor ◽  
Female Fertility ◽  
Β Subunit ◽  
Subunit Gene ◽  
Lh Surge ◽  
Female Mice ◽  
Serum Lh ◽  
Lowered Serum

Ovulation in the mouse and other mammals is controlled by hormones secreted by the hypothalamo-pituitary-ovarian axis. We describe anovulation and infertility in female mice lacking the microRNAs miR-200b and miR-429. Both miRNAs are strongly expressed in the pituitary gland, where they suppress expression of the transcriptional repressor ZEB1. Eliminating these miRNAs, in turn, inhibits luteinizing hormone (LH) synthesis by repressing transcription of its β-subunit gene, which leads to lowered serum LH concentration, an impaired LH surge, and failure to ovulate. Our results reveal roles for miR-200b and miR-429, and their target the Zeb1 gene, in the regulation of mammalian reproduction. Thus, the hypothalamo-pituitary-ovarian axis was shown to require miR-200b and miR-429 to support ovulation.

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