The effect of drospirenone (3mg) with ethinyl estradiol (30mcg) containing pills on ovarian blood flows in women with polycystic ovary syndrome: a case controlled study

Objective To evaluate the effects of nutritional counseling on the dietary habits and anthropometric parameters of overweight and obese adolescents with polycystic ovary syndrome (PCOS). Methods This was a prospective, longitudinal and auto-controlled study. Thirty adolescents aged 13–19 years-old, diagnosed with PCOS received nutritional counseling and were followed-up for 6 months. After the follow-up period, the results were evaluated through body weight, body mass index (BMI) and waist circumference (WC). Results Sixty-percent of the adolescents adhered to the nutritional counseling and, of these, 50% lost weight. Adolescents who lost weight changed their dietary habits by adopting hypocaloric diets and eating more meals per day, as per nutritional counseling. The waist circumference (WC) decreased significantly, although the body weight decreased non-significantly after adoption of a hypocaloric diet. Conclusion Although there was no significant weight loss, there was a considerable reduction in the WC associated with hypocaloric diets and with eating a greater number of meals per day.

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Increased Activation of Nuclear Factor κB Triggers Inflammation and Insulin Resistance in Polycystic Ovary Syndrome

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2005-2327 ◽

2006 ◽

Vol 91 (4) ◽

pp. 1508-1512 ◽

Cited By ~ 107

Author(s):

Frank González ◽

Neal S. Rote ◽

Judi Minium ◽

John P. Kirwan

Keyword(s):

Insulin Resistance ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Nuclear Factor Κb ◽

Controlled Study ◽

Plasma Testosterone ◽

Nuclear Factor ◽

Ovary Syndrome ◽

Percent Change ◽

Glucose Ingestion

Context: Insulin resistance and chronic low level inflammation are often present in women with polycystic ovary syndrome (PCOS). Objective: The purpose of this study was to determine the effects of hyperglycemia on nuclear factor κB (NFκB) activation and inhibitory κB (IκB) from mononuclear cells (MNC) in PCOS. Design and Setting: This was a prospective controlled study conducted at an academic medical center. Patients: The study population consisted of 16 reproductive-age women with PCOS (eight lean, eight obese) and 16 age- and body composition-matched controls (eight lean, eight obese). Main Outcome Measures: Insulin sensitivity (IS) was derived from a 2-h 75-g oral glucose tolerance test (ISOGTT). Intranuclear NFκB and IκB protein expression were quantitated from MNC obtained from blood drawn fasting and 2 h after glucose ingestion. Results: ISOGTT was lower in PCOS compared with controls (3.3 ± 0.3 vs. 6.4 ± 0.9, P < 0.004). The percent change in intranuclear NFκB was higher in lean and obese PCOS compared with lean controls (42.5 ± 19.1 and 54.5 ± 12.5 vs. −14.1 ± 10.9, P < 0.006). The percent change in intranuclear NFκB correlated positively with 2-h post-glucose ingestion levels (r = 0.37; P < 0.04) and plasma testosterone (r = 0.49; P < 0.006) and correlated negatively with ISOGTT (r = 0.39; P < 0.04). The percent change in IκB was lower in lean and obese PCOS compared with lean controls (−22.3 ± 3.2 and −17.0 ± 5.0 vs. 8.4 ± 11.8, P < 0.02). Conclusion: In response to hyperglycemia, intranuclear NFκB increases and IκB decreases in MNC of women with PCOS independent of obesity. This may represent a cardinal inflammatory signal that contributes to the induction of insulin resistance and hyperandrogenism in PCOS.

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Clinical and metabolic effects of medroxyprogesterone acetate and ethinyl estradiol plus drospirenone in women with polycystic ovary syndrome

International Journal of Gynecology & Obstetrics ◽

10.1016/j.ijgo.2008.05.017 ◽

2008 ◽

Vol 103 (1) ◽

pp. 44-49 ◽

Cited By ~ 19

Author(s):

Suna Özdemir ◽

Hüseyin Görkemli ◽

Kazim Gezginç ◽

Mustafa Özdemir ◽

Aysel Kiyici

Keyword(s):

Polycystic Ovary Syndrome ◽

Medroxyprogesterone Acetate ◽

Ethinyl Estradiol ◽

Polycystic Ovary ◽

Metabolic Effects ◽

Ovary Syndrome

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Atorvastatin Increases 25-Hydroxy Vitamin D Concentrations in Patients with Polycystic Ovary Syndrome

Clinical Chemistry ◽

10.1373/clinchem.2010.144014 ◽

2010 ◽

Vol 56 (11) ◽

pp. 1696-1700 ◽

Cited By ~ 35

Author(s):

Thozhukat Sathyapalan ◽

John Shepherd ◽

Charlotte Arnett ◽

Anne-Marie Coady ◽

Eric S Kilpatrick ◽

...

Keyword(s):

Vitamin D ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Statin Treatment ◽

Vitamin D Supplementation ◽

Significant Rise ◽

Controlled Study ◽

Ovary Syndrome ◽

Double Blind ◽

Markers Of Inflammation

BACKGROUND It has been shown that many women with polycystic ovary syndrome (PCOS) are 25-hydroxyvitamin D (25OHD) insufficient. Both statin treatment and vitamin D supplementation have been shown to improve biochemical hyperandrogenemia, insulin resistance, and markers of inflammation in patients with PCOS, raising the possibility that some of the statin effects are mediated through vitamin D. METHODS We conducted this randomized, double-blind placebo controlled study to assess the effect of atorvastatin on serum 25OHD concentrations in patients with PCOS. Forty medication-naive patients with PCOS were randomized to either atorvastatin 20 mg daily or placebo for 3 months. After completing the initial 3 months of atorvastatin or placebo, both groups of patients participated in a 3-month extension study with metformin 1500 mg daily. We measured changes in 25OHD concentrations by use of tandem mass spectrometry. RESULTS Mean (SD) baseline 25OHD concentrations were comparable between the 2 groups [45.9 (2.4) vs 44.8 (1.8) nmol/L; P = 0.7]. There was a significant increase in 25OHD concentrations with atorvastatin [45.9 (2.4) vs 60.8 (3.5) nmol/L] compared with placebo [44.8 (1.8) vs 41.8 (3.2) nmol/L; P = 0.02]. Three-month treatment with metformin maintained the improvement of 25OHD with atorvastatin compared to baseline [45.9 (2.4) vs 61.8 (3.5), P ≤ 0.01). There were no significant changes in 25OHD concentrations in the placebo group after 12 weeks of metformin. CONCLUSIONS Among patients with polycystic ovary syndrome, 12 weeks of atorvastatin led to a clinically significant rise in 25OHD concentrations. This may represent a beneficial pleiotropic effect of statins on 25OHD concentrations.

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