Optimal treatment strategies for small cell carcinoma of the uterine cervix: A retrospective multi-center study (KROG 19-03)

Definitive cytomorphologic diagnosis of small cell carcinoma of the uterine cervix is possible but can be challenging in routine cervicovaginal cancer screening specimens. Several small series of reported cases of cervical small cell carcinoma have shown this uncommon malignancy to represent fewer than 2% of all invasive cervical cancers. This tumor type is associated with poor prognosis and rapid disease progression and can develop to an advanced stage in the interval between screening visits. Only rare case reports of small cell carcinoma arising in gravid cervices are known. In the current case a 29-year-old, gravida 6, para 2, pregnant (10-week gestation) female presented with postcoital bleeding. A definitive diagnosis of small cell carcinoma of the cervix was made possible by liquid based Pap testing with ancillary cell block preparation allowing for immunocytochemical characterization of the lesional cell population.

Download Full-text

Small Cell Carcinoma of the Uterine Cervix Misdiagnosed as Squamous Cell Carcinoma

Cancer and Clinical Oncology ◽

10.5539/cco.v2n1p36 ◽

2012 ◽

Vol 2 (1) ◽

Author(s):

Aymen Lagha ◽

Nadia Bouzid ◽

Samia Kanoun Belajouza ◽

Soumaya Labidi ◽

Asma Saiidi ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Squamous Cell ◽

Uterine Cervix ◽

Small Cell

Download Full-text

Adjuvant chemotherapies for small cell carcinoma of the uterine cervix

Cancer Treatment An Update ◽

10.1007/978-2-8178-0765-2_100 ◽

1994 ◽

pp. 479-481

Author(s):

T. C. Chang ◽

H. C. Chang ◽

C. H. Lai ◽

S. Hsueh ◽

S. F. Huang ◽

...

Keyword(s):

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Uterine Cervix ◽

Small Cell

Download Full-text

P16ink4a overexpression and human papillomavirus infection in small cell carcinoma of the uterine cervix

Human Pathology ◽

10.1016/s0046-8177(03)00284-3 ◽

2003 ◽

Vol 34 (8) ◽

pp. 778-783 ◽

Cited By ~ 74

Author(s):

Nobuo Masumoto ◽

Takuma Fujii ◽

Mitsuya Ishikawa ◽

Miyuki Saito ◽

Takashi Iwata ◽

...

Keyword(s):

Human Papillomavirus ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Uterine Cervix ◽

Small Cell ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection

Download Full-text

Complete Response of Recurrent Small Cell Carcinoma of the Uterine Cervix to Paclitaxel, Carboplatin, and Bevacizumab Combination Therapy

Case Reports in Oncology ◽

10.1159/000506446 ◽

2020 ◽

Vol 13 (1) ◽

pp. 373-378 ◽

Cited By ~ 1

Author(s):

Yuri Nakao ◽

Satoshi Tamauchi ◽

Nobuhisa Yoshikawa ◽

Shiro Suzuki ◽

Hiroaki Kajiyama ◽

...

Keyword(s):

Lymph Node ◽

Combination Therapy ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Uterine Cervix ◽

Posterior Wall ◽

Complete Response ◽

Uterine Sarcoma ◽

Small Cell ◽

Lymph Node Sampling

We report a case of recurrent small cell carcinoma of the uterine cervix that showed a complete response to paclitaxel, carboplatin, and bevacizumab (TC + Bev) combination therapy. Small cell carcinoma of the uterine cervix is extremely rare, with an incidence of only 1.3% in Japan, and a poor outcome. The patient was a 62-year-old woman with a chief complaint of irregular vaginal bleeding. Magnetic resonance imaging showed a 10-cm irregular mass from the uterine corpus’s posterior wall to the cervix. Abdominal total hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymph node sampling were performed for suspected uterine sarcoma. Histopathological findings revealed small cell carcinoma with lymph node metastasis. Although 6 cycles of etoposide + cisplatin were performed, para-aortic lymph node recurrence was found 3 months after chemotherapy. Subsequently, the patient received 8 cycles of TC + Bev, which eliminated the metastases. The patient is currently alive at 24 months.

Download Full-text