Palliative sedation at end of life—A systematic literature review

2007 ◽  
Vol 11 (1) ◽  
pp. 26-35 ◽  
Author(s):  
Joakim Engström ◽  
Erik Bruno ◽  
Birgitta Holm ◽  
Ove Hellzén
Keyword(s):  
Literature Review ◽  
End Of Life ◽  
Systematic Literature Review ◽  
Palliative Sedation

scholarly journals Antibiotic Use at the End-of-Life in Patients with Advanced Dementia: A Systematic Literature Review

2020 ◽  
Vol 41 (S1) ◽  
pp. s120-s120
Author(s):  
Alexandre Marra ◽  
Mireia Puig-Asensio ◽  
Eli Perencevich
Keyword(s):  
Literature Review ◽  
Cohort Studies ◽  
End Of Life ◽  
Systematic Literature Review ◽  
End Of Life Care ◽  
Final Analysis ◽  
Antibiotic Use ◽  
Life Care ◽  
Advanced Dementia ◽  
Days Of Therapy

Background: Improving the use of antibiotics across the care continuum will be necessary as we strive to protect our patients from antimicrobial resistance. One potential target for antimicrobial stewardship is during end-of-life care of patients with advanced dementia. We aimed to perform a systematic literature review measuring the burden of antibiotic use during end-of-life care in patients with dementia. Methods: We searched PubMed, CINAHL, and Embase through July 2019 for studies with the following inclusion criteria in the initial analysis: (1) end-of-life patients (ie, dementia, cancer, organ failure, frailty or multi-morbidity); (2) antibiotic use in the end-of-life care; with the final analysis restricted to (3) patients with advanced dementia. Only randomized controlled trials (RCTs) and cohort studies were included. Results: Of the 93 full-text articles, 17 studies (18.3%) met the selection criteria for further analysis. Most of the included studies were retrospective (n = 8) or prospective (n = 8) cohort studies. These studies in combination included 2,501 patients with advanced dementia. Also, 5 studies (698 patients, [27.9%]) were restricted to patients with Alzheimer’s disease. In 5 studies in which data were available, fewer than one-quarter of patients (19.9%, 498) with advanced dementia were referred to palliative care. In 12 studies >50% of patients received antibiotics during the end-of-life period. Also, 15 studies did not report the duration of antimicrobial therapy. Only 2 studies reported the antimicrobial consumption in days of therapy per 1,000 resident days. Only 6 studies studied whether the use of antibiotics was associated with beneficial outcomes (survival or comfort), and none of them evaluated potential adverse effects associated with antibiotic use. Conclusions: There are significant gaps in the literature surrounding antimicrobial use at the end of life in patients with advanced dementia. Future studies are needed to evaluate the benefits and harms of using antibiotics for patients during end-of-life care in this patient population.Acknowledgement. We thank Jennifer Deberg from Hardin Library for the Health Sciences, University of Iowa Libraries on the search methods.Disclosures: NoneFunding: None

scholarly journals End-of-life care conversations with heart failure patients: a systematic literature review and narrative synthesis

2011 ◽  
Vol 61 (582) ◽  
pp. e49-e62 ◽  
Author(s):  
Stephen Barclay ◽  
Natalie Momen ◽  
Steve Case-Upton ◽  
Isla Kuhn ◽  
Elizabeth Smith
Keyword(s):  
Heart Failure ◽  
Literature Review ◽  
End Of Life ◽  
Systematic Literature Review ◽  
End Of Life Care ◽  
Narrative Synthesis ◽  
Life Care ◽  
Heart Failure Patients

scholarly journals Integrative Literature Review Nursing Interventions Aimed at the Family of the Person in End of Life Under Palliative Sedation.

2017 ◽  
Author(s):  
Silvina Maria da Costa Moura Moura ◽  
João Pedro Afonso Gonçalves ◽  
Patrícia Pontífice de Sousa
Keyword(s):  
Literature Review ◽  
End Of Life ◽  
Palliative Sedation ◽  
Nursing Interventions ◽  
The Family
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