scholarly journals Using a simple equation to predict the microporation-enhanced transdermal drug flux

2018 ◽  
Vol 127 ◽  
pp. 12-18 ◽  
Author(s):  
Alexey S. Rzhevskiy ◽  
Krishna Telaprolu ◽  
Yousuf H. Mohammed ◽  
Jeffrey E. Grice ◽  
Michael S. Roberts ◽  
...  
Keyword(s):  
Simple Equation ◽  
Drug Flux

scholarly journals Amorphous Ropinirole-Loaded Mucoadhesive Buccal Film: A Potential Patient-Friendly Tool to Improve Drug Pharmacokinetic Profile and Effectiveness

2020 ◽  
Vol 10 (4) ◽  
pp. 242
Author(s):  
Giulia Di Prima ◽  
Giuseppina Campisi ◽  
Viviana De Caro
Keyword(s):  
Buccal Mucosa ◽  
Therapeutic Strategy ◽  
Therapeutic Response ◽  
Ex Vivo ◽  
Hepatic Metabolism ◽  
Pharmacokinetic Profile ◽  
Promising Candidate ◽  
Steady State Condition ◽  
Drug Pharmacokinetic ◽  
Drug Flux

Nowadays the therapeutic strategies to manage Parkinson’s Disease are merely symptomatic and consist of administering L-DOPA and/or dopamine receptor agonists. Among these, Ropinirole (ROP) is a widely orally-administered molecule, although it is extensively susceptible to hepatic metabolism. Since literature reports the buccal mucosa as a potentially useful route to ROP administration, the development of novel, effective, and comfortable oromucosal formulations should prove desirable in order to both enhance the therapeutic efficacy of the drug and allow a personalized therapeutic strategy able to meet the patient’s needs. The results of the proposed ROP film as a new dosage form show that it is flexible; uniform; and characterized by suitable surface pH; good mucoadhesiveness; low swelling degree; and fast, complete drug release. Moreover, after ex vivo evaluation on a film having an area of 0.282 cm2 and dose of 2.29 mg, the results of drug flux through the buccal mucosa are closely comparable to the amount of ROP that reaches the bloodstream at the steady-state condition after ROP-PR 4 mg oral administration, calculated according to the literature (0.237 mg/cm2·h−1 vs. 0.243 mg/h, respectively). Moreover, drug flux and ROP dose could be accurately modulated time-by-time depending on the patient’s need, by varying the administered disk area. In addition, the proposed ROP film displays no lag time, producing an immediate drug input in the bloodstream, which could result in a prompt therapeutic response. These findings make ROP film a potentially comfortable and patient-friendly formulation, and a promising candidate for further clinical trials.

scholarly journals Analytical mathematical schemes: Circular rod grounded via transverse Poisson’s effect and extensive wave propagation on the surface of water

Open Physics ◽  
2020 ◽  
Vol 18 (1) ◽  
pp. 545-554
Author(s):  
Asghar Ali ◽  
Aly R. Seadawy ◽  
Dumitru Baleanu
Keyword(s):  
Wave Propagation ◽  
Partial Differential Equations ◽  
Differential Equations ◽  
Longitudinal Wave ◽  
Symbolic Computation ◽  
Boussinesq Equation ◽  
Nonlinear Partial Differential Equations ◽  
Wave Model ◽  
Simple Equation ◽  
Partial Differential

AbstractThis article scrutinizes the efficacy of analytical mathematical schemes, improved simple equation and exp(-\text{Ψ}(\xi ))-expansion techniques for solving the well-known nonlinear partial differential equations. A longitudinal wave model is used for the description of the dispersion in the circular rod grounded via transverse Poisson’s effect; similarly, the Boussinesq equation is used for extensive wave propagation on the surface of water. Many other such types of equations are also solved with these techniques. Hence, our methods appear easier and faster via symbolic computation.

scholarly journals On the correlation between the spectra of various hæmoglobins and their relative affinities for oxygen and carbon monoxide

1924 ◽  
Vol 97 (680) ◽  
pp. 61-83 ◽  
Keyword(s):  
Carbon Monoxide ◽  
Simple Equation ◽  
Forms Of Life ◽  
Α Band

The spectra of the hæmoglobins from different animals, and even different mammals, are measurably different. The relative affinities of these hæmoglobins for oxygen and carbon monoxide are also different, and it turns out that certain properties of the chemical affinities and of the spectra are so related that by the use of a simple equation they may be deduced from one another. That the spectra of the hæmoglobins of all forms of life are not the same was discovered by Sorby (1), and has since been verified by Vlès (2), who has carefully mapped out the spectra of a number of animals, notably Arenicola and the horse. The particular difference with which we are concerned in this paper is in the position of the α-band, which was found by J. and H. Barcroft (3) to occupy a place in Arenicola 18 Angstrom units from that which it occupies in man. The considerations which have led us to undertake the present research are to be found in their paper.

The prediction of voluntary intake of grazing dairy cows

1986 ◽  
Vol 107 (1) ◽  
pp. 43-54 ◽  
Author(s):  
Lindsey Caird ◽  
W. Holmes
Keyword(s):  
Organic Matter ◽  
Measurement Techniques ◽  
Live Weight ◽  
Simple Equation ◽  
Factors Affecting ◽  
Farm Planning ◽  
Sward Height ◽  
The Mean ◽  
Major Factors ◽  
Grazing Dairy Cows

SUMMARYInformation on the total organic matter intake, concentrates supplied (C), live weight (LW), week of lactation (WL), milk yield (MY), herbage organic matter digestibility (HOMD), herbage mass, sward height (SHT) or herbage allowance (HAL) measured individually for 357 cows at one of three sites was assembled. Observed intake was compared with intakes predicted by existing intake equations and new prediction equations based on regression models or regression and least-squares constants were developed. Major factors affecting intake were MY, LW, WL, C and HAL or SHT. Although HOMD was correlated with intake, better predictions were obtained when HOMD was omitted. There were differences between sites possibly associated with differences in measurement techniques.The predictive value of some existing equations and new equations were tested against independent sets of data. A simple equation (A) based on MY and LW (Ministry of Agriculture, Fisheries and Food, 1975) gave satisfactory average predictions but the mean square prediction error (MSPE) was high. The equations of Vadiveloo & Holmes (1979) adjusted for bias gave a relatively low MSPE. The preferred new equations for grazing cattle included MY, LW, WL, C and HAL or SHT, and their MSPE were similar to or lower than for indoor equations.The discussion indicates that a simple equation (A) would give adequate predictions for farm planning. The more detailed equations illustrate the inter-relations of animal with sward conditions and concentrate allowances. Predicted intakes may deviate from actual intakes because of short-term changes in body reserves.

Role of Stratum Corneum Lipid Fluidity in Transdermal Drug Flux

1987 ◽  
Vol 76 (1) ◽  
pp. 25-28 ◽  
Author(s):  
Guia M. Golden ◽  
James E. McKie ◽  
Russell O. Potts
Keyword(s):  
Stratum Corneum ◽  
Lipid Fluidity ◽  
Stratum Corneum Lipid ◽  
Drug Flux

Preparation and Vibration Damping Characteristics of Wide Frequency Domain PVMQ/IIR Foam Materials

2012 ◽  
Vol 538-541 ◽  
pp. 2298-2303
Author(s):  
Shi Kai Luo ◽  
Guo Fang Ding ◽  
Jing Li Li ◽  
Yan Song Sha ◽  
Qing Min Cheng ◽  
...  
Keyword(s):  
Frequency Domain ◽  
Wide Temperature Range ◽  
Damping Ratio ◽  
Vibration Damping ◽  
Simple Equation ◽  
Structural Damping ◽  
Damping Characteristics ◽  
Damping Materials ◽  
Foaming Technology ◽  
Isoprene Rubber

In this paper, we prepared foaming silicon rubber (PVMQ) /isobutylene-isoprene rubber (IIR) composites with chemical foaming technology. The DMA tests results showed that these foaming materials have effective damping characteristics in a wide temperature range. With the special vibrator, we found that the PVMQ/IIR foams that we prepared were the damping materials which has wide frequency domain, because they can keep high damping ratio in a wide frequency domain. When the preloading was between 1.0 mm and 1.7 mm, the structural damping did not change obviously. According to tests, we found that the damping ratio of these foams was fit to the simple equation .

Optical soliton perturbation with Gerdjikov–Ivanov equation by modified simple equation method

Optik ◽  
2018 ◽  
Vol 157 ◽  
pp. 1235-1240 ◽  
Author(s):  
Anjan Biswas ◽  
Yakup Yildirim ◽  
Emrullah Yasar ◽  
Houria Triki ◽  
Ali Saleh Alshomrani ◽  
...  
Keyword(s):  
Optical Soliton ◽  
Simple Equation ◽  
Equation Method ◽  
Soliton Perturbation ◽  
Modified Simple Equation Method
Sign in / Sign up

Export Citation Format

Share Document