SOLVENT INFLUENCE ON MANUFACTURABILITY, PHASE BEHAVIOR AND MORPHOLOGY OF AMORPHOUS SOLID DISPERSIONS PREPARED VIA BEAD COATING

2021 ◽  
Author(s):  
Eline Boel ◽  
Flavia Giacomini ◽  
Guy Van den Mooter
Keyword(s):  
Phase Behavior ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersions ◽  
Solvent Influence

scholarly journals Solvent influence on the phase behavior and glass transition of Amorphous Solid Dispersions

2021 ◽  
Vol 158 ◽  
pp. 132-142 ◽  
Author(s):  
Stefanie Dohrn ◽  
Christian Luebbert ◽  
Kristin Lehmkemper ◽  
Samuel O. Kyeremateng ◽  
Matthias Degenhardt ◽  
...  
Keyword(s):  
Glass Transition ◽  
Phase Behavior ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersions ◽  
Solvent Influence

Influence of Low-Molecular-Weight Excipients on the Phase Behavior of PVPVA64 Amorphous Solid Dispersions

2018 ◽  
Vol 35 (1) ◽  
Author(s):  
Kristin Lehmkemper ◽  
Samuel O. Kyeremateng ◽  
Matthias Degenhardt ◽  
Gabriele Sadowski
Keyword(s):  
Molecular Weight ◽  
Phase Behavior ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Low Molecular Weight ◽  
Amorphous Solid Dispersions

scholarly journals Development of a Surface Coating Technique with Predictive Value for Bead Coating in the Manufacturing of Amorphous Solid Dispersions

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 878
Author(s):  
Eline Boel ◽  
Piyush Panini ◽  
Guy Van den Mooter
Keyword(s):  
Phase Behavior ◽  
Spray Drying ◽  
Surface Coating ◽  
Drug Loading ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Film Casting ◽  
Amorphous Solid Dispersions ◽  
Coating Technique ◽  
Amorphous System

The aim of this paper was to investigate whether a surface coating technique could be developed that can predict the phase behavior of amorphous solid dispersions (ASDs) coated on beads. ASDs of miconazole (MIC) and poly(vinylpyrrolidone-co-vinyl acetate) (PVP-VA) in methanol (MeOH) were studied as a model system. First, the low crystallization tendency of the model drug in MeOH was evaluated and confirmed. In a next step, a drug loading screening was performed on casted films and coated beads in order to define the highest possible MIC loading that still results in a one-phase amorphous system. These results indicate that film casting is not suitable for phase behavior predictions of ASDs coated on beads. Therefore, a setup for coating a solid surface was established inside the drying chamber of a spray dryer and it was found that this surface coating technique could predict the phase behavior of MIC-PVP-VA systems coated on beads, in case an intermittent spraying procedure is applied. Finally, spray drying was also evaluated for its ability to manufacture high drug-loaded ASDs. The highest possible drug loadings that still result in a one-phase amorphous system were obtained for bead coating and its predictive intermittent surface coating technique, followed by spray drying and finally by film casting and the continuous surface coating technique, thereby underlining the importance for further research into the underexplored bead coating process.

Phase Behavior of Poly(vinylpyrrolidone) Containing Amorphous Solid Dispersions in the Presence of Moisture

2009 ◽  
Vol 6 (5) ◽  
pp. 1492-1505 ◽  
Author(s):  
Alfred C. F. Rumondor ◽  
Patrick J. Marsac ◽  
Lindsay A. Stanford ◽  
Lynne S. Taylor
Keyword(s):  
Phase Behavior ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersions

Variation in Supersaturation and Phase Behavior of Ezetimibe Amorphous Solid Dispersions upon Dissolution in Different Biorelevant Media

2017 ◽  
Vol 15 (1) ◽  
pp. 193-206 ◽  
Author(s):  
Ahmed Elkhabaz ◽  
Sreya Sarkar ◽  
Janny K. Dinh ◽  
Garth J. Simpson ◽  
Lynne S. Taylor
Keyword(s):  
Phase Behavior ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersions ◽  
Biorelevant Media
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