Solid-State NMR Investigation of Drug-Excipient Interactions and Phase Behavior in Indomethacin-Eudragit E Amorphous Solid Dispersions

2018 ◽  
Vol 35 (3) ◽  
Author(s):  
Joseph W. Lubach ◽  
Jonathan Hau
Keyword(s):  
Solid State ◽  
Phase Behavior ◽  
Solid State Nmr ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersions ◽  
Eudragit E ◽  
Excipient Interactions

Investigation of Drug–Excipient Interactions in Lapatinib Amorphous Solid Dispersions Using Solid-State NMR Spectroscopy

2015 ◽  
Vol 12 (3) ◽  
pp. 857-866 ◽  
Author(s):  
Yang Song ◽  
Xinghao Yang ◽  
Xin Chen ◽  
Haichen Nie ◽  
Stephen Byrn ◽  
...  
Keyword(s):  
Solid State ◽  
Nmr Spectroscopy ◽  
Solid State Nmr ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersions ◽  
Solid State Nmr Spectroscopy ◽  
Excipient Interactions

Analysis of Amorphous Solid Dispersions Using 2D Solid-State NMR and1HT1Relaxation Measurements

2010 ◽  
Vol 7 (5) ◽  
pp. 1667-1691 ◽  
Author(s):  
Tran N. Pham ◽  
Simon A. Watson ◽  
Andrew J. Edwards ◽  
Manisha Chavda ◽  
Jacalyn S. Clawson ◽  
...  
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersions

scholarly journals Enhanced Oral Bioavailability of Resveratrol by Using Neutralized Eudragit E Solid Dispersion Prepared via Spray Drying

Antioxidants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 90
Author(s):  
Eun-Sol Ha ◽  
Du Hyung Choi ◽  
In-hwan Baek ◽  
Heejun Park ◽  
Min-Soo Kim
Keyword(s):  
Spray Drying ◽  
Solid Dispersion ◽  
Oral Bioavailability ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Pharmaceutical Products ◽  
In Vitro Dissolution ◽  
Dependent Manner ◽  
Amorphous Solid Dispersions ◽  
Eudragit E

In this study, we designed amorphous solid dispersions based on Eudragit E/HCl (neutralized Eudragit E using hydrochloric acid) to maximize the dissolution of trans-resveratrol. Solid-state characterization of amorphous solid dispersions of trans-resveratrol was performed using powder X-ray diffraction, scanning electron microscopy, and particle size measurements. In addition, an in vitro dissolution study and an in vivo pharmacokinetic study in rats were carried out. Among the tested polymers, Eudragit E/HCl was the most effective solid dispersion for the solubilization of trans-resveratrol. Eudragit E/HCl significantly inhibited the precipitation of trans-resveratrol in a pH 1.2 dissolution medium in a dose-dependent manner. The amorphous Eudragit E/HCl solid dispersion at a trans-resveratrol/polymer ratio of 10/90 exhibited a high degree of supersaturation without trans-resveratrol precipitation for at least 48 h by the formation of Eudragit E/HCl micelles. In rats, the absolute oral bioavailability (F%) of trans-resveratrol from Eudragit E/HCl solid dispersion (10/90) was estimated to be 40%. Therefore, trans-resveratrol-loaded Eudragit E/HCl solid dispersions prepared by spray drying offer a promising formulation strategy with high oral bioavailability for developing high-quality health supplements, nutraceutical, and pharmaceutical products.

Influence of Low-Molecular-Weight Excipients on the Phase Behavior of PVPVA64 Amorphous Solid Dispersions

2018 ◽  
Vol 35 (1) ◽  
Author(s):  
Kristin Lehmkemper ◽  
Samuel O. Kyeremateng ◽  
Matthias Degenhardt ◽  
Gabriele Sadowski
Keyword(s):  
Molecular Weight ◽  
Phase Behavior ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Low Molecular Weight ◽  
Amorphous Solid Dispersions
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